Patients with inflammatory bowel disease (IBD) often face the complex challenge of multiple coexisting symptoms, and systematic assessment and management of symptom clusters are key to improving prognosis. This article provides a systematic review and analysis of domestic and international literature on symptom clusters in patients with IBD, briefly introduces the clinical characteristics of these symptom clusters, and summarizes the types, applicability, reliability, validity, and current application status of related assessment tools. At present, assessment tools for symptom clusters in patients with IBD still require optimization in terms of standardization and individualization. In the future, more precise symptom cluster management systems should be developed to provide a basis for research and clinical management of symptom clusters in these patients, thereby enhancing the precision of symptom management.