Objective To investigate the research development of the liver stem cell(LSC) and to predict its future application. Methods Based on our own researches and combined with the review of the related literature at home and abroad, we analyzed and evaluated the latest development of the research on the LSC. Results We knew the differentiation and proliferation of the LSC towards some kinds of specified cells were affected by many factors; and the researches on the LSC in regard to its activation, isolating culture, bolting, and evaluation still needed further improvements. Conclusion With the development of the research, the liver stem cell can become a new seed cell to cure some liver diseases.