Objective To systematically review the association between prothrombin gene G20210A mutation and the risk of cerebral venous thrombosis (CVT). Methods Databases including PubMed, Springer, Google Scholar, The Cochrane Library (Issue 1, 2016), CNKI, WanFang Data and CBM were searched for case-control studies concerning the association between prothrombin gene G20210A mutation and cerebral venous thrombosis risk from inception to January 2016. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software and Stata 12.0 software. Results A total of 26 case-control studies were included, involving 1 361 CVT cases and 6 323 controls. The results of meta-analysis showed that: there was a significant association between prothrombin gene G20210A mutation and CVT risk (OR=4.56, 95% CI 3.51 to 5.93,P<0.000 01). Sensitivity analysis showed no significant publication bias was detected confirmed the stability of results. Subgroup analysis showed that G20210A mutation increased CVT risk in adults (OR=5.02, 95% CI 3.81 to 6.60,P<0.000 01), but not in children (OR=1.99, 95% CI 0.83 to 4.79,P=0.12). Conclusion Prothrombin gene G20210A mutation can significantly increase the CVT risk. Due to the limited quality and quantity of included studies, the above results are needed to be validated by more high quality studies.
目的 比較低頻與高頻探頭超聲對急性闌尾炎的診斷價值。 方法 對2010年1月－2011年6月120例急性闌尾炎的手術病理結果與超聲檢查結果進行回顧性分析，比較低、高頻探頭超聲對急性闌尾炎的診斷價值。 結果 120例急性闌尾炎中，通過低頻探頭超聲檢出67例（55.8%），通過高頻探頭超聲檢出105例（87.5%）；單純性闌尾炎以及化膿性和壞疽性闌尾炎高頻探頭超聲檢出例數明顯大于低頻探頭超聲，差異有統計學意義（P＜0.05）；闌尾周圍膿腫低、高頻探頭超聲均全部檢出。 結論 高頻探頭超聲對急性闌尾炎的檢出率高于低頻探頭超聲，但二者各有所長，在臨床中聯合應用能有效提高急性闌尾炎的超聲診斷符合率。