以臨床醫學實驗教學中心構建為依托,緊密結合實驗教學新體系的構建,建立高水平的和對外開放的實驗室,理論聯系實際,重新構建臨床醫學實驗教學課程體系,并根據新的臨床醫學實驗課程體系對原有的臨床醫學實驗教學內容和教學模式進行改進和調整。充分發揮臨床醫學實驗教學中心的作用,促進臨床醫學實驗室向綜合性、多功能、開放性的大型實驗室轉變。建立臨床醫學實驗教學實習基地,提高臨床醫學實驗教學質量,培養學生的實踐能力和創新能力,全面推進臨床醫學實驗教學中心的建設和管理水平。
bjectiveTo study the therapeutic effect and mechanism of photodynamic therapy (PDT) to the nude mice model of pancreatic cancer by intratumoral injecting photosensitizers hematoporphyrin derivatives (HpD), hypocrellin A (HA) and 2butylamino2demethoxyhypocrellin A (2BA2DMHA).MethodsThe animal model of human pancreatic cancer was developed by injecting human pancreatic cancer cells SW1990 into the back of the nude mice. After photosensitizers HpD, HA and 2BA2DMHA was given by the intratumoral injection, the 632.8 nm HeNe laser was used to irradiate the tumor. The curative effect was recorded and factorⅧ was used in the immunohistochemical staining to study the vessel change. ResultsPDT can destroy the pancreatic neoplasm, the tumor growth rate was significantly reduced after PDT. The immunohistochemical staining showed PDT could make injury to vessel endothelial cell.ConclusionPDT can induce injuries of pancreatic cancer; vascular injury is an important way to exert function.