【摘要】 目的 調查分析有家庭成員在汶川地震中傷亡的再生育夫婦自然流產的相關危險因素。 方法 通過回顧性問卷調查方式，2008年9月-2011年3月收集整理44對震后有自然流產的再生育夫婦基本資料和自然流產相關危險因素，分析該類人群震后自然流產危險因素特點。 結果 自然流產發生率占總妊娠比例的22.9%，11.1%的女性出現了震后月經改變，有人流史婦女與無人流史婦女震后月經改變率比較，差異無統計學意義（χ2=0.58，Pgt;0.05）。 結論 震后女性易發生月經改變，地震后再生育夫婦的自然流產發生率顯著高于正常人群中的自然流產發生率，環境、高齡等因素可能是該人群自然流產高發的主要危險因素。【Abstract】 Objective To explore the risk factors of spontaneous abortion related in reproduction-needed couples after the earthquake. Methods Between September 2008 and March 2011, 44 pairs of reproduction-needed couples were investigated by retrospective questionnaire. The risk factors of spontaneous abortion were analyzed. Results The spontaneous abortion rate was 22.9%; 11.1% females had the menstruation changes. The difference in the rate of the menstruation changes between the females had spontaneous abortion history and the ones didn′t had the history was not significant (χ2=0.58，Pgt;0.05). Conclusions The females after the earthquake may have menstruation changes; the spontaneous abortion rate in reproduction-needed couples after the earthquake is obviously higher than that in the normal couples. The risk factors may include the environment and the age.
Objective To evaluate the correlation between blood eosinophilia and clinical characteristics, readmission rate and mortality in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wanfang Data, VIP, and CBM databases were searched until October 31, 2021. Two researchers independently screened the literature, extracted the data, and evaluated the bias risk of the included studies. Meta-analysis was conducted by Rev Man v.5.4. Results Finally, 76 observational studies met the inclusion criteria, including 15 English literatures and 61 Chinese literatures. There were 8240 patients (34.20%) in the eosinophilia group (EOS≥2%) and 15854 cases (65.8%) in the eosinophil normal group (EOS<2%). Results of meta-analysis: (1) Inflammatory Index: eosinophilia group had lower C-reactive protein [MD=–8.44, 95%CI (–10.59, –6.29), P<0.05], and lower neutrophil to lymphocyte ratio [MD=–2.47, 95%CI (–3.13, –1.81), P<0.05]. (2) Hospitalization: eosinophilia group had shorter hospital stay [MD=–2.23, 95%CI (–2.64, –1.81), P<0.05] and lower in-hospital mortality [OR=0.41, 95%CI (0.31, 0.53), P<0.05], lower mechanical ventilation rate [OR=0.59, 95%CI (0.47, 0.75), P<0.05], lower hormone use rate [OR=0.91, 95%CI (0.85, 0.96), P<0.05]. (3) Follow-up results: eosinophilia group had a lower rate of readmission at 1 year [OR=0.78, 95%CI (0.66, 0.92), P<0.05] and a lower rate of death at 1 year [OR=0.78, 95%CI (0.62, 0.97), P<0.05]. Conclusions AECOPD patients with eosinophilia group were characterized by lower inflammatory indicators, shorter hospital stay, shorter in-hospital mortality, lower mechanical ventilation rate, lower hormone use rate, lower rate of acute exacerbation readmission, lower mortality rate and lower rate of follow-up after 1 year. This kind of patients with mild disease, good treatment effect, low risk of acute exacerbation.