目的 探討表現為足潰瘍的惡性黑色素瘤臨床特點。 方法 回顧性分析2002年1月－2010年12月收治的46例表現為足潰瘍的惡性黑色素瘤患者。 結果 46例均病理組織活檢確診，男29例，女17例，平均年齡57歲。潰瘍形成前多表現為包塊、黑素斑、痣、水泡、灰指甲、雞眼、疣等；潰瘍形成后表現為外傷不愈或反復復發、潰瘍中央或邊緣破潰、不規則、表面凹凸不平、顆粒狀或呈瘢痕狀態、焦痂、菜花樣新生物等；潰瘍好發部位為足底、足跟、足趾；3例患者無色素沉著；確診前潰瘍存在時間為（10.74 ± 10.94）個月，38例患者（82.6%）在確診前誤診，中位誤診時間為6個月（2.75～48個月），分別被誤診為黑色素斑、痣、慢性潰瘍、黑色包塊等。確診時18例存在遠處轉移；35例進行手術治療，3例采用單純化學治療，8例放棄治療。 結論 惡性黑色素瘤早期表現不典型，常被誤診，由于其高度侵襲性，對表現不典型的足潰瘍應提高警惕，盡早行病理組織學檢查，以減少其誤診。
Objective To establish the reference intervals for platelet-related parameters among the elderly population in Longquanyi District, Chengdu. Methods From November 1st to December 31st 2021, elderly individuals aged between 60 and 80 years were selected from the Longquanyi branch of a natural population cohort study initiated by West China Hospital of Sichuan University in 2021. Complete blood cell analysis was performed to obtain the platelet-related parameters. IBM SPSS Statistics 25 software was used to analyze the data and establish the reference intervals for platelet-related parameters among the elderly population in Longquanyi District. Results A total of 1938 reference individuals were selected by inclusion and exclusion criteria, and finally 1669 reference individuals, including 665 males and 1004 females, were included to establish the reference intervals after excluding outliers. The reference range of blood platelet count was (95.03-301.32)×109/L for elderly men and (112.13-320.75)×109/L for elderly women, respectively. The reference range of mean platelet volume was 8.97-13.80 fL for elderly men and 9.10-13.90 fL for elderly women, respectively. The reference range of plateletcrit was 0.13%-0.30% for elderly men and 0.14%-0.32% for elderly women, respectively. The reference range of platelet distribution width was 15.80-16.90 for elderly men and 15.70-16.90 for elderly women, respectively. Conclusion It is of practical significance to establish platelet-related parameters in the elderly in local region.