目的:探討干擾素治療水痘的效果。方法:將151例水痘患者隨機分為3組, 治療組Ⅰ給予干擾素100 萬U/ 次,im,隔日1 次,連用3 次,治療組Ⅱ同時予以干擾素局部外涂于水痘處, 2 次/ d;對照組病毒唑10 mg/ (kg·d),im, 一日2 次,連用5 天。除以上治療外,3組均同時根據病情給予退熱、止癢、抗炎等對癥治療。觀察3組患者癥狀、體征變化。結果:治療組患者癥狀、體征恢復所用時間明顯優于對照組,同時還發現局部外涂干擾素于水痘處,其皮疹瘙癢、結痂恢復天數明顯縮短。結論:干擾素治療水痘可減輕癥狀,縮短病程,配合局部外用效果更佳。
Alveolar bone reconstruction simulation is an effective means for quantifying orthodontics, but currently, it is not possible to directly obtain human alveolar bone material models for simulation. This study introduces a prediction method for the equivalent shear modulus of three-dimensional random porous materials, integrating the first-order Ogden hyperelastic model to construct a computed tomography (CT) based porous hyperelastic Ogden model (CT-PHO) for human alveolar bone. Model parameters are derived by combining results from micro-CT, nanoindentation experiments, and uniaxial compression tests. Compared to previous predictive models, the CT-PHO model shows a lower root mean square error (RMSE) under all bone density conditions. Simulation results using the CT-PHO model parameters in uniaxial compression experiments demonstrate more accurate prediction of the mechanical behavior of alveolar bone under compression. Further prediction and validation with different individual human alveolar bone samples yield accurate results, confirming the generality of the CT-PHO model. The study suggests that the CT-PHO model proposed in this paper can estimate the material properties of human alveolar bone and may eventually be used for bone reconstruction simulations to guide clinical treatment.