目的 探討手術切除聯合液氮冷凍治療結膜鱗狀細胞癌的臨床效果。 方法 分析1998年-2008年收治的21例眼瞼結膜鱗癌患者的臨床資料。對腫瘤局限在眼球結膜和部分穹窿結膜受侵犯者行單純手術切除聯合液氮冷凍治療；部分或全部結膜及眼瞼受侵犯者行局部腫瘤切除聯合眼瞼重建及液氮冷凍治療；眼瞼和球結膜廣泛受累，無法進行眼瞼重建者行眼眶內容物剜除術。 結果 21例中，7例行單純腫瘤切除合并冷凍治療，其中5例痊愈，2例復發；10例行局部腫瘤切除并進行眼瞼重建，其中7例痊愈，3例復發，復發病例作眶內容摘除；4例腫瘤侵犯范圍較寬而無法保留眼球者行眼眶內容物摘除。術手3例死于肝肺轉移。 結論 眼瞼結膜鱗狀細胞瘤的外科手術切除是唯一有效的方法，眼瞼重建視腫瘤侵犯范圍而定，冷凍治療作為輔助治療可提高疾病的治愈率。
Poly(styrene-block-isobutylene-block-styrene) (SIBS) and its crosslinked product crosslinked polyisobutylene (xPIB) are a kind of novel thermoplastic elastomer. They have excellent biocompatibility and stability, which are suitable for long-term implantation in human body. At present, SIBS is widely used in cardiovascular diseases, and also has preliminary application in ophthalmology. This article reviews the application and research progress of SIBS and xPIB in ophthalmic glaucoma minimally drainage tube material, intraocular lens material, new sclera buckle material and orbital defect filler, with a view of providing reference for the clinical application of such biomedical materials in ophthalmology.
OBJECTIVE: To study the clinical effects of allosclera transplant for eyelid reconstruction. METHODS: From May 1986 to January 2001, 45 patients who suffered from partial eyelid defect underwent the allosclera transplant for eyelid reconstruction, There were 31 cases of male and 14 cases of female, 18 cases of the upper eyelid and 27 cases of the lower eyelid, among them, 22 cases were caused by eyelid trauma and 23 cases by eyelid tumor. The length of eyelid defect were less than 1/2 of the whole eyelid. The morphology and function of the eyelid and complications were observed after operation. RESULTS: All 45 cases were followed up for 11 to 38 months, 19.7 months on average. The eyelid morphology and mobility restored well and there was no influence on visual function. CONCLUSION: The xenosclera is an ideal material for eyelid reconstruction.
【摘要】 目的 探討結膜惡性黑色素瘤的手術治療方法。 方法 1997年1月-2007年1月收治結膜惡性黑色素瘤48例，均為單眼。腫瘤范圍:lt;1/3眼瞼長度及結膜14例，gt;1/3眼瞼長度，部分穹隆結膜受累19例，上下眼瞼及內外眥大部分結膜受累者15例。采用單純腫瘤切除術、單純腫瘤切除聯合液氮冷凍治療、眼眶內容物剜除術3種治療方法。 結果 所有患者均經病理學證實為結膜惡性黑色素瘤 。術后48例進行9個月～5年隨訪，15例眶內容物剜除術，3例死于肺及顱腦轉移；14例單純擴大腫瘤切除聯合液氮冷凍治療，2例死于肝轉移；19例單純擴大腫瘤切除術，6例分別死于肝、肺及顱腦轉移。 結論 早期診斷并選擇積極有效的手術治療是提高患者生存率，改善生存質量的重要手段。手術切除聯合液氮冷凍法可有效降低腫瘤復發，避免影響患者視覺質量和外觀，是治療結膜惡性黑色素瘤的一種有效方法。【Abstract】 Objective To investigate the surgical therapeutics for malignant melanoma of eyelid conjunctiva. Methods A total of 48 patients with monocular malignant melanoma of eyelid conjunctiva from January 1997 to January 2007 were collected. The scope of the melanoma involved lt;1/3 eyelid length and conjunctiva in 14, gt;1/3 eyelid length and part of conjunctival formix in 19, and upper and lower eyelid and most of the conjunctiva of medial and lateral canthus in 15. Eye socket exenteration,tumor resection combine with eyelid reconstruction, tumor resection were used. Results All of the patients were diagnosed as malignant melanoma of eyelid conjunctiva by pathological examination. The follow-up period was 9 months-5 years. Among the 15 patients who had undergone eye socket exenteration,3 died. Among the 14 patients who had undergone expand tumor resection combine with liquid nitrogen frozen, 2 died. Among the 19 patients who had undergone tumor resection combine with eyelid reconstruction, 6 died. Conclusion Tumor resection combine with liquid nitrogen frozen is effective on malignant melanoma of eyelid conjunctiva.
ObjectiveTo evaluate the effectiveness of a new type of sutured titanium wire combined with titanium nail internal fixation in correction of serious old medial canthus deformity.MethodsBetween March 2012 and June 2015, 18 patients with unilateral serious old medial canthus deformity were treated. There were 14 males and 4 females. The patient’s age ranged from 23 to 62 years (mean, 42 years). The causes of deformity included accident injury in 10 cases, boxing injury in 4 cases, sharp device scratching in 3 cases, and animal bite in 1 case. All patients had been treated with suture or steel wire fixation in other hospitals to correct the medial canthus deformity and the deformity recurred. The interval between this operation and the first operation was 6 months to 2 years (mean, 16 months). The nasal root or medial canthus skin scar incision was used as the operative approach, and the adhesion of the medial canthus ligament to the adjacent tissues was fully loosened, then the tail end of the new type sutured titanium wire was fixed to the residual end of the medial canthus ligament. After passing through the scar tissue, the needle end of wire was fixed on the titanium nail in the bone wall of anterior lacrimal crest. The position and shape of the medial canthus angle was determined by adjusting the tightness of titanium wire.ResultsAll incisions healed by first intention. All patients were followed up 6-12 months (mean, 10 months). In 16 cases, the medial canthus deformity was obviously corrected, and the appearances of bilateral eyes were basically symmetrical, without exposure of titanium nail and titanium wire. The medial canthus was retreated at 2 mm after 6 months in 2 cases, who were satisfied with their appearance without reoperation.ConclusionApplication of the new type of suture titanium wire combined with titanium nail in the correction of serious old medial canthus deformity can achieve good effectiveness with the low recurrence rate.
【摘要】 目的 研究ΔNP63/TAP63在上皮性卵巢腫瘤組織中的表達及其與臨床病理特征的關系。 方法 運用熒光定量聚合酶鏈反應方法檢測2002年-2004年54例卵巢上皮性腫瘤中ΔNP63/TAP63的基因水平。 結果 33例卵巢上皮細胞癌組織中ΔNP63的表達高于21例良性上皮性腫瘤中組織。卵巢上皮細胞癌中的表達強度與腫瘤組織病理學分期相關（Plt;0.05），良性腫瘤的表達低于惡性腫瘤（Plt;0.05）。ΔNP63的表達高于TAP63（Plt;0.05）；各組間TAP63的表達差異無統計學意義（Pgt;0.05）。 結論 ΔNP63在上皮性卵巢癌中高表達，可能成為上皮性卵巢癌診斷及預后的分子標志物。【Abstract】 Objective To explore the expression of ΔNP63 / TAP63 in human epithelial ovarian tumor tissues and its relationship with the clinicopathological features. Methods Fluorescent quantitative PCR method was used to detect 54 cases of ΔNP63 / TAP63 gene level in 54 patients with epithelial ovarian tumors diagnosed between 2002 and 2004. Results ΔNP63 expression in the 33 cases of ovarian epithelial cell carcinoma was higher than that in the 21 cases of benign epithelial tumor tissue. The expression in ovarian epithelial cell carcinoma was concerned with the pathological staging of tumor (Plt;0.05); the expression in benign tumors was lower than that in the malignant tumors (Plt;0.05). In all cases, the expression of ΔNP63 was higher than that of TAP63 (Plt;0.05); the difference in the expression of TAP63 among the groups was not significant (Pgt;0.05). Conclusion ΔNP63 in epithelial ovarian cancer is highly expressed, which may become the molecular makers with diagnosis and prognosis of epithelial ovarian cancer diagnosis in the future.