Objective To analyze the causes of drug dispensing errors and reduce the error rate through scientific precautions, and improve the quality of pharmaceutical service. Methods According to the PDCA cycle, existing problems were found in dispensing between January and June 2013, and the causes were analyzed. Then, from July 2013, strategies were developed to decrease the dispensing error rate. The variation trend of dispensing error rate from January 2013 to June 2017 were observed. Result The dispensing error rate decreased since the beginning of PDCA cycle, from 0.042‰ (the first quarter of 2013) to 0.003‰ (the second quarter of 2017). Conclusion The PDCA cycle is an effective intervention to detect the errors during drug delivery in inpatient pharmacy, which could improve the quality of pharmaceutical service and insure the patients’ safety.
Objective To establish a method for quality control of Astragalus Radix and Scutellariae Radix in Biqiaotong granules and provide basis for the establishment of quality standard. Methods The single-factor test method was used to investigate the factors of thin layer chromatography (TLC) conditions, including different extract method and solvents, developing system, comogemc agents, temperature, humidity, drawing amounts and thin layer boards, and to screen the best TLC conditions of Astragalus Radix and Scutellariae Radix . Results The TLC conditions of Astragalus Radix were used trichloromethane-methanel-water (13:7:2) as developing solvent, separated on silica gel G, heatd under 105℃ until the spots bacame clear. The TLC conditions of Scutellariae Radix were used methylbenzene-ethy acetate- formic acid-methanel (9:3:2:2) as developing solvent, separated on silica gel G, observed after 30 minutes under daylight until the spots were clear. Conclusions The spot features are clear, and with good separating degree, strong specificity, and good repeatability without the inference of negative control. The TLC method is simple, sensitive and accurate, which can be adopted for the quality control of Biqiaotong granules.
目的 分析四川大學華西醫院麻醉性鎮痛藥應用的現狀及趨勢，并行客觀評價。 方法 對2008年－2010年四川大學華西醫院麻醉性鎮痛藥品的種類、用量、金額、用藥頻度等進行歸類統計、比較和分析。 結果 住院部使用麻醉藥品的用量及金額呈上升趨勢。臨床應用以芬太尼類居首。新型麻醉藥品的應用也有上升趨勢。 結論 麻醉性鎮痛藥的應用基本合理，但創建無痛醫院仍需進一步完善，并提交合理用藥水平。
目的 研究環氧合酶-2抑制劑藥物的應用狀況和發展趨勢，為臨床合理、有效、經濟地選用藥物提供科學依據。 方法 采用金額排序和用藥頻度（DDDs）、日均費用（DDC）方法，對四川大學華西醫院2008年－2010年環氧合酶-2抑制劑藥物的臨床應用情況進行統計分析。 結果 2008年－2010年間，該院環氧合酶-2抑制劑藥物的應用數量和銷售金額呈逐年上升趨勢，其中選擇性環氧合酶-2抑制劑藥物的用量增幅較大，非選擇性環氧合酶-2抑制劑藥物用量呈下降趨勢。 結論 該院環氧合酶-2抑制劑藥物臨床應用合理，選擇性環氧合酶-2占主導地位，有較好的發展前景。
【摘要】 目的 考察用烏頭堿水解物、新烏頭堿水解物、次烏頭堿水解物的含量作為附片水煎劑及附片質量控制指標的可行性。 方法 采用高效液相色譜分析法，色譜柱為Shimpack CLC-ODS，以甲醇-乙酸銨溶液（0.2 mol/L）（200︰210）為流動相，流速1.0 mL/min，檢測波長為241 nm，對烏頭堿新，烏頭堿、次烏頭堿水解物的含量測定進行研究。 結果 3種水解物檢測方法測得水解物在進樣范圍有良好線性關系，重現性好，穩定性好，生藥提取時間宜選定為40 min，不同批號的附片中3種水解物含量差別較大。 結論 此方法簡便，使用新烏頭堿、烏頭堿、次烏頭堿的水解物作為含附片制劑的質量控制指標是可行的。【Abstract】 Objective To examine the feasibility of regarding the hydrolyzate from aconitine, new aconitine, and hypaconitine to be the decoction of radix aconite and the quality control index. Methods High performance liquid chromatographic method (HPLC) method was adopted. Shimpack CLC-ODS column with UV detection at 241 nm was used. The mobile phase consisted of (200∶210), and the flow rate was 1.0 mL/min. Results The content of the hydrolysis objects in the water decoction and toxicity were correlated with each other, and the contents of hydrolysis were significantly different among different groups of radix aconiti. Conclusion This method is simple, accurate and effective for content research of hydrolyzate from aconitine-type alkaloids in Monkshoo decoction of Radix Aconiti, and it is feasible to take it as the quality control index.