【摘要】 目的 了解原發性開角型青光眼患者用2%鹽酸卡替洛爾滴眼液后的眼壓及眼脈動幅度變化特征。 方法 選取2009年1－12月確診為原發性開角型青光眼患者19例32只眼。給予2%鹽酸卡替洛爾滴眼液點眼1周，2次/d。用動態輪廓眼壓計測量患者用藥前后的眼壓、眼脈動幅度，同時測量患者的血壓及心率。比較用藥前后眼壓及眼脈動幅度的變化，并用SPSS 14.0統計學軟件對用藥前后的眼壓及眼脈動幅度數據進行配對t檢驗及Pearson相關性分析。 結果 患者用藥前后眼壓分別為（22.76±4.29）、（17.79±2.93） mm Hg（1 mm Hg=0.133 kPa），眼脈動幅度分別為（3.47±1.00）、（2.63±0.86） mm Hg。患者的眼壓及眼脈動幅度用藥后較用藥前明顯降低，差異有統計學意義（Plt;0.01），用藥前后的眼壓與眼脈動幅度之間存在正相關關系（r=0.444， 0.364；P=0.011， P=0.040）。眼壓及眼脈動幅度與患者的血壓及心率均無相關性。 結論 原發性開角型青光眼患者用2%鹽酸卡替洛爾滴眼液后眼壓及眼脈動幅度均有顯著降低，眼壓與眼脈動幅度有正相關性。眼壓及眼脈動幅度與血壓及心率無相關關系。【Abstract】 Objective To investigate the variations of intraocular pressure (IOP) and ocular pulse amplitude (OPA) in patients with primary open-angle glaucoma after 2% carteolol hydrochloride was applied. Methods Thirty-two eyes of 19 patients with primary open-angle glaucoma diagnosed between January and December 2009 were chosen to be the study subjects. The patients received 2% cartelol hydrochloride eye drops twice a day for one week. IOP and OPA before and after using cartelol were measured by dynamic contour tonometry (DCT). Blood pressure and heart rate were detected at the same time. The variations of IOP and OPA were analyzed by SPSS 14.0. t test and Pearson correlation analysis were applied. Results The mean IOP and OPA before and after using cartelol were respectively (22.76±4.29) mm Hg (1 mm Hg=0.133 kPa) vs. (17.79±2.93) mm Hg, and (3.47±1.00) mm Hg vs. (2.63±0.86) mm Hg. Both of them decreased significantly after the use of cartelol (P＜0.01). OPA was obviously correlated with IOP both before and after using cartelol (r=0.444, 0.364; P=0.011, 0.040). OPA and IOP had no correlation with blood pressure and heart rate. Conclusions OPA and IOP decreases signifficantly after the use of 2% carteolol hydrochloride. OPA is signifficantly correlated with IOP. OPA and IOP have no correlation with blood pressure and heart rate.