目的：探討宮頸微小偏離性腺癌的診斷與治療。方法：按照WHO(2003)宮頸腺癌分類標準，回顧性分析我院收治的8例宮頸微小偏離性腺癌的臨床病理資料。結果：宮頸微小偏離性腺癌占同期收治宮頸浸潤腺癌的4.73％，臨床表現為水樣白帶和/或生殖道出血、宮頸肥大變硬和贅生物，陰道B超檢查示宮腔積液，宮頸細胞學診斷較困難，常需深部活檢組織診斷。結論：診斷應結合臨床表現，影像學檢查，宮頸細胞學。當高度懷疑時應取深部組織或宮頸錐切組織診斷，早期診治預后較好。
Objective To compare the effectiveness of aspheric intraocular lenses(IOL) versus spherical IOL in the treatment of cataract. Method Randomized controlled trials comparing aspheric IOL with spherical IOL were identified by searching PubMed (2000 to October, 2008), EMbase (2000 to October, 2008), MEDLINE (2000 to October, 2008), and The Cochrane Library (Issue 3, 2008). Two reviewers independently assessed trials for eligibility and quality, as well as the extracted data. Data were synthesized using RevMan software (release 5) provided by the Cochrane Collaboration. Results A total of 14 trials (1383 eyes) were included for systematic review, and 11 out of 14 studies were included in the meta-analysis. Subgroup analyses were used according to different aberrations of aspheric IOL. The results showed a significant difference in the mean best corrected visual acuity at 3 months after cataract surgery in the AcrySof IQ IOL group with WMD -0.02, 95% CI -0.03 to -0.01(Plt;0.0001). It showed a significantly worse difference in the mean of the best corrected visual acuity at 3 months after cataract surgery in the AcrySof IQ IOL group with WMD –0.02, 95%CI –0.03 to –0.01 (Plt;0.000 1). It showed a significant worse in the mean the best corrected visual acuity in the Tecnis Z9000 IOL group with WMD 0.02, 95%CI 0.01 to 0.03 (P=0.002); and there was no significant difference between the two groups with WMD 0.00, 95%CI –0.02 to –0.03 (P=0.71). The results did display markedly less spherical aberration and total higher order aberrations than eyes implanted with the traditional spheric IOL in all subgroups (WMD –0.06, 95%CI –0.07 to –0.06, Plt;0.000 01, WMD –0.06, 95%CI –0.07 to –0.02, Plt;0.000 1, respectively). The majority of studies suggested significant improvement in the aspheric IOL group in contrast sensitivity, especially at mesopic low spatial frequencies, although some trials showed no significant difference. Conclusion The effectiveness of aspheric IOL is superior to spherical IOL during cataract surgery. No differences in aspheric IOL with different aberration are found in this series, and further study is required.
ObjectiveTo systematically reviewed the progress of Zelen’s design and its modifications in clinical research and clarified its methodological elements, advantages, and limitations. MethodsA systematic literature search was conducted for Zelen’s design from databases. The data were extracted. ResultsOne hundred and twenty-four trials were included. The dominant disease in this design was mental disorders, followed by osteoarthrosis diseases, cancer, cardiovascular diseases, and others. Regarding types of consent, more than half of the trials used a double-consent (71, 57.26%), and 42 used a single-consent. Eleven trials used a modified Zelen’s design nested within an observational study. This design used a two-stage informed consent. Stage 1, patients were invited to participate in a cohort study; Stage 2, patients randomized in the experimental group were informed of the allocation result and asked whether they would like to follow the treatment. Five trials used the McNulty-Zelen design, which could be applied in cluster randomized controlled trials and overcome the potential bias of the Hawthorne effect. Intention-to-treat analysis was the main population used in Zelen’s design. ConclusionZelen’s design has a broad application in the foreground in clinical trials. It could also be used to adapt to research needs by combining with various observational studies. Zelen’s design offers unique advantages in reducing recruitment difficulty, improving patient compliance, and minimizing bias. Although the randomization of patients without their prior consent raises potential ethical concerns, these can be addressed through methods such as nested observational studies or supplementary informed consent. In real-world applications of Zelen’s design, it is necessary to design a reasonable informed consent strategy and data statistical analysis method according to the research context. Attention must be paid to the impact of sample size, group shifting and selection of dataset on the results, to improve the interpretability and accuracy of the results.