變應原特異性免疫治療(SIT)是目前已知的唯一能改變變態反應性疾病患者對變應原免疫的類型，并有可能治愈變態反應性疾病的方法。通常是通過反復多次皮下注射，即皮下免疫治療(SCIT)，誘導患者對變應原的耐受，但因其不良反應較大，并有可能引起過敏性休克等原因而使其應用受到限制。近來通過舌下含服的方法進行免疫治療，即舌下免疫治療(SLIT)，引起了臨床上廣泛的興趣。與SCIT相比，SLIT完全由患者自己使用藥物，因此更方便，臨床研究也證實這種方法更安全，也更有效。而且與藥物治療相比，SLIT可以顯著降低臨床費用，減輕患者和社會的負擔。但是SLIT誘導免疫耐受的確切機制目前仍不清楚。
Objective To investigate the effects of FasL gene-modified dendritic cell (DC) on the airway inflammation in mice sensitized/challenged by house dust mite (HDM) allergen.Methods FasL gene-modified DC (FasL-DC) and control DC (nontransfection DC) were administrated into HDM sensitized and challenged mice by intratracheal injection respectively，then HDM sensitized and challenged mice were sacreificed two days later.Total and differentiation cell counts and levels of interleukin-4（IL-4），IL-5 and interferon-γ(IFN-?) in bronchoalveolar lavage fluid (BALF) were detected and lung histological features were observed.Results After administration of FasL-DC，lung allergic inflammation was ameliorated while total cell counts，the percentage of eosinophil ,the levels of IL-4 and IL-5 in BALF decreased and the level of IFN-? in BALF increased.Conclusion Administrating FasL-DC into HDM sensitized/challenged mice can inhibit Th2 cells activation and ameliorate airway allergic inflammation.