Acute isolated meniscal injury is a common sports-related knee injury in clinical practice. In June 2024, the American Academy of Orthopaedic Surgeons (AAOS) released the latest Clinical Practice Guideline for the Management of Acute Isolated Meniscal Pathology. Based on rigorous evidence-based methodology, the guideline provides systematic recommendations regarding physical examination, imaging evaluation, and both non-operative and operative management strategies, classifying these recommendations according to the strength of evidence. This article aims to interpret the key points in the diagnosis and management of acute isolated meniscal injury, to inform clinical practice and guide future research.