Objective This study aimed to explore the relationship between serum lipid and lipoprotein levels and occurrence of breast cancer, and relationship between serum lipid and lipoprotein levels and clinicopathological characteristics of breast cancer patients. Methods Clinical data of 788 patients with breast cancer and 395 patients with benign breast disease were retrospectively collected, who received treatment in The First Affiliated Hospital of Chongqing Medical University from January 2014 to March 2016, and to explore the relationship between levels of total cholesterol (TC)/triglyceride (TG)/high density lipoprotein cholesterol (HDL-c)/low density lipoprotein cholesterol (LDL-c) and occurrence of breast cancer/ clinicopathological characteristics of breast cancer patients. Results ① Influencing factors that affected the occurrence of breast cancer: multifactor logistic analysis showed that, height (OR=0.950, P=0.006), body mass index (OR=1.062, P=0.041), and serum LDL-c level (OR=1.349, P=0.016) were independent influencing factors for occurrence of breast cancer, people had high body mass index and higher level of serum LDL-c had high risk of breast cancer, but people had high height had low risk of breast cancer. ②Association analysis of serum lipid and lipoprotein levels and clinicopathological characteristics of breast cancer patients: the serum TC level was correlated with expression of progesteronereceptors (PR) and lymph node metastasis status (P<0.05), the serum TC levels of patients with negative-expression of PR and lymph node metastasis were slightly higher than that of patients with positive-expression of PR and non-lymph node metastasis; the serum TG level was associated with body mass index (P<0.05), that the serum TG level of patients with body mass index≥25 kg/m2was slightly higher than that of patients with body mass index<25 kg/m2; the serum HDL-c level was correlated with the body mass index and diameter of the tumor (P<0.05), the serum HDL-c level of the patients with body mass index≥25 kg/m2 was slightly lower than that of patients with body mass index<25 kg/m2, the serum HDL-c level of patients with the tumor diameter≤2 cm was slightly higher than that of patients with the tumor diameter >2 cm; the serum LDL-c level was correlated with body mass index, expression of estrogenreceptors (ER) and PR, and molecular typing ( P<0.05), the serum LDL-c level was slightly higher in patients with body mass index≥25 kg/m2, negative expression of ER and PR, and non Luminal type patients, comparing with patients with body mass index<25 kg/m2, positive expression of ER and PR, and Luminal type patients. Conclusions High level of serum LDL-c is strongly associated with occurrence of breast cancer, and levels of serum lipid and lipoprotein are associated with expression of hormone receptor, molecular type of breast cancer, and status of lymph node, but it needs further randomized controlled studies to confirm.
目的:了解四川省直機關省廳級公務員超重、肥胖的現狀,探討體重指數、腰圍與血脂的關系。方法:2008年對四川省直機關省廳級公務員取樣調查1260人測身高,體重,腰圍(WC),血脂,計算體重指數(BMI),并對男女各組間膽固醇、甘油三酯進行統計學分析。結果:四川省直機關省廳級公務員的男女肥胖率分別為9.1%、7.7%,超重率分別為45.3%、27.8%,肥胖組及超重組甘油三酯明顯高于正常組,多元回歸分析結果顯示男女性甘油三酯與BMI、WC均有明顯相關性(Plt;0.01)。結論:防治高血脂,控制肥胖及腹型肥胖甚為重要,體重指數、腰圍的控制也為防治高血脂的基本措施之一。
ObjectiveTo investigate the role of apelin, glycosylated hemoglobin (HbA1c), cholesterol (TC), triglyceride (TG), High density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC) in the development and progress of diabetic retinopathy (DR). MethodsThe serum concentration of apelin, HbA1c, TC, TG, HDLC and LDLC were measured in 30 normal control subjects and 90 patients with type 2 diabetic mellitus, including 30 cases without DR (NDR), 30 with non-proliferative DR (NPDR), 30 with proliferative DR (PDR). These data were analyzed by SPSS for windows 13.0. ResultsThe serum concentration of apelin, HbA1c, TC, HDLC, LDLC were significantly higher in NDR, NPDR, PDR group than those in control group (F=403.06, 5.45, 4.27, 201.56, 4.90;P < 0.05). The serum concentration of TG has no significantly difference (F=2.19, P > 0.05). The serum concentration of apelin, HbA1c, TC, LDLC were significantly higher in NDR, NPDR, PDR group than those in control group (t=0.30, 0.58, 0.79;P < 0.05), the serum concentration of HDLC were significantly lower than those in control group(t=0.79, P < 0.01). There were significantly positive correlation between the progression of DR and the serum concentration of apelin, HbA1c, TC, LDLC(r=0.962, 0.562, 0.935;P < 0.05). There were significantly negative correlation between the progression of DR and the serum concentration of HDLC(r=-0.753, P < 0.01). There were correlation between apelin and HbA1c, LDLC and HDLC(r=0.956, 0.741, -0.691;P < 0.01). ConclusionOur data demonstrated that serum apelin levels increased significantly in patients with diabetic retinopathy, and are closely related to blood sugar, blood lipid metabolic abnormalities.
The present study was designed to elucidate the role of apoE polymorphism in the lithogenesis of cholecystolithiasis and to explore the hereditary pathogenesis of the disease. Polymerase Chain Reaction (PRC) was used as researching apoE phenotypes and allele frequencies in patients with gallstones (n=87) and in controls (n=50), and the fasting serum lipids of subjects were also measured. The characteristics of lipid variants were analysed among the patients with different apoE phenotypes. The results showed that the levels of TG (1.43mmol/L), VLDL-C(0.68mmol/L) in E2/3 patients were greatly higher than those in E2/3 controls (1.06mmol/L, Ｐ＜0.05 and 0.48mmol/L, Ｐ＜0.05), and LDL-C (1.41mmol/L) was markably lower in E2/3 patients than that in controls (2.04mmol/L, Ｐ＜0.05). The levels of serum lipids decreased significantly in E3/3 patients with HDL-C (0.89mmol/L), HDL2-C (0.49mmol/L), HDL3-C (0.39mmol/L), and compared with those in E3/3 controls (1.28mmol/L Ｐ＜0.05, 0.73mmol/L Ｐ＜0.001 and 0.55mmol/L Ｐ＜0.001). In E3/4 patients there were only slight changes of VLDL-C, LDL-C level. The results suggest that the average level of serum lipids in the same apoE phenotype patients with gallstones is higher than that in controls, and the different apoE phenotypes patients with gallstones have different characteristics of dyslipidemia. ε2 allele is probably one of the dangerous factor in the lithogenesis of cholecystolithiasis.
ObjectiveTo systematically review the intervention effects of high-intensity interval training (HIIT) on weight loss and blood lipid metabolism in overweight/obese populations. MethodsThe computer conducted searches in the PubMed, Embase, Cochrane Library, Web of Science, CNKI, and WanFang Data database to collect randomized controlled trials (RCTs) related to HIIT and weight loss, fat reduction, and blood lipid metabolism in overweight/obese populations. The search was conducted from the inception of the databases to March 31, 2023. Two researchers independently conducted literature screening and data extraction. After evaluating the risk of bias of the included studies, a meta-analysis was performed using RevMan 5.4 software. ResultsA total of 19 RCTs, involving 595 overweight/obese participants, were included. The meta-analysis results showed that compared wtih the control group, HIIT interventions effectively reduced body weight (MD=?2.63, 95%CI ?4.04 to ?1.23, P<0.05), BMI (MD=?1.21, 95%CI ?1.95 to ?0.48, P<0.05), Fat% (MD=?1.66, 95%CI ?2.28 to ?1.04, P<0.05), TG (MD=?0.13, 95%CI ?0.25 to ?0.01, P=0.04), HDL (MD=0.14, 95%CI 0.05 to 0.23, P<0.05), and LDL (MD=?0.26, 95%CI ?0.39 to ?0.13, P<0.05) levels but did not improve TC (MD=?0.15, 95%CI ?0.36 to 0.06, P=0.15) levels. ConclusionHIIT intervention can effectively improve body weight, BMI, Fat%, TG, HDL, and LDL levels in overweight/obese populations, particularly showing a more pronounced improvement in lipid profiles among overweight/obese adolescents, but it does not reduce TC levels. This study demonstrates that HIIT may be an effective strategy to assist in weight loss and prevent cardiovascular diseases in overweight/obese populations, with potential for broader application.
Dyslipidemia plays an important role in the pathogenesis of diabetic retinopathy (DR).Apreliminary study found that low-density lipoprotein cholesterol, apolipoprotein (Apo)Band ApoB/ Apo A1 ratio were positively correlated with DR, while high-density lipoprotein cholesterol, Apo A1 was negatively correlated with DR and proliferative DR. Reducing the blood fats to be helpful to DR control. However, the mechanism of hyperlipidemia in the pathogenesis of DR, the reason of dyslipidemia in diabetic patients and the interaction between hyperglycemia and hyperlipidemia in DR are not clear yet. Moreover, there is no predictive indicators related to blood lipid for DR. Understanding the relationship between dyslipidemia and DR can provide definite evidence for fat-reducing therapy for DR control.
【摘要】 目的 探討頸動脈粥樣硬化(CAS)斑塊及血脂、血糖(BG)、纖維蛋白原(Fbg)水平與腦梗死的關系。方法 對2007年11月—2008年12月入院的91例腦梗死患者,應用彩色多普勒檢測其頸動脈內中膜厚度(IMT)、斑塊數和性狀,同時檢測血脂、血糖、纖維蛋白原水平,并與正常對照組比較。結果 ①與正常對照組比較,腦梗死組IMT明顯增厚、CAS斑塊檢出率、軟斑百分比明顯增高(Plt;005)。②血清總膽固醇(TC)、低密度脂蛋白(LDL)、BG及Fbg水平腦梗死組明顯高于正常對照組(Plt;005);腦梗死有斑塊亞組明顯高于無斑塊亞組(Plt;005)。③腦梗死組IMT與TC、LDL、BG、Fbg水平(r分別為0.32、0.34、0.30、0.36,Plt;005)。結論 腦梗死患者IMT增厚,CAS斑塊及軟斑發生率高。BG、TC、LDL及Fbg水平增高是腦梗死及CAS斑塊發生的危險因素。
目的 探討成都地區中老年人群的腰高比值（WHtR）與血壓、血脂、血糖的關系。 方法 2007年5月間在成都市地中老年人群（688人）中用統一編制的調查表記錄被調查者的血壓、血脂、血糖、WHtR等指標，并用相關統計學數據進行分析。 結果 ① 成都地區中老年人群WHtR≥0.5的高血壓、高血脂、高血糖的發病率明顯高于對照組（P＜0.05），且有統計學意義。② 年齡、收縮壓、舒張壓、甘油三酯和血糖水平，WHtR≥0.5組明顯高于WHtR＜0.5組，而WHtR≥0.5組高密度脂蛋白水平低于WHtR＜0.5組，且組間差異均有統計學意義。③ logistic 回歸分析表明WHtR與年齡、收縮壓、舒張壓、甘油三酯、空腹血糖水平呈正相關，與高密度脂蛋白水平呈負相關。 結論 成都地區中老年人群WHtR與血壓、血脂及血糖關系密切，可能可以通過改善血壓、血脂、空腹血糖等指標來減少WHtR，中老年人群要加強對 WHtR 的自我管理, 盡可能將心血管疾病危險因素降到最低。