Search

Research progress of mitochondrial DNA as a pathogenic factor in diseases

Mitochondrial DNA (mtDNA) is the circulating genome in mitochondria, and it is easy to accumulate oxidative damage, causing mitochondrial dysfunction, and then cell dysfunction, and even tissue and body pathological changes, leading to diseases. As a pro-inflammatory, inflammatory, and even predictive factor, mtDNA is directly involved in the inflammatory response and the pathogenesis of many diseases. This article aims to review the current pathogenesis of mtDNA damage and its pathogenic role in various human diseases.

腰大池引流腦脊液治療主動脈夾層術后截癱六例

心臟術后急性上腔靜脈綜合征兩例

雙瓣膜置換術后長Q—T間期綜合征并發尖端扭轉型室性心動過速一例

三尖瓣置換術的臨床應用

目的 總結三尖瓣置換術(tricuspid valve replacement, TVR)治療三尖瓣病變的經驗，探討手術指征、方法，以提高臨床治療效果。方法 回顧性分析2003年1月至2007年4月期間24例接受TVR患者的臨床資料，其中風濕性心臟病15例，Ebstein畸形5例，先天性三尖瓣發育不良2例，感染性心內膜炎1例，外傷1例；再次手術患者4例。 結果 院內死亡2例，死亡率8.3%（2/24）。術后發生并發癥2例，其中一過性Ⅲ°房室傳導阻滯1例，安置心內臨時起搏器20d后恢復；病態竇房結綜合征1例，經使用臨時心外膜起搏器15d后，恢復自主心律。經門診隨訪19例(86.4%)，心功能恢復至Ⅰ級12例，Ⅱ級7例。 結論 嚴格把握手術指征，加強圍術期處理，行TVR安全、可靠、療效滿意。

Influence of Levosimendan on Severe Valvular Disease Patients with Atrial Fibrillation Undergoing Cardiac Surgery: A Randomized Controlled Trial

ObjectiveThrough comparing the efficacy of levosimendan with dopamine for severe valvular disease patients with atrial fibrillation surgery to explore the efficacy and safety of levosimendan used in cardiac surgery. MethodsWe allocated 48 severe valvular disease patients with atrial fibrillation surgery into a dopamine group (24 patients with 15 males and 9 females at age of 55.0 ± 17.4 years) and a levosimendan group (24 patients with 18 males and 6 females at age of 52.3 ± 16.2 years) by random digital table in the Affiliated Hospital of Luzhou Medical College between February and June 2014. The effects of the two groups were compared. ResultsHospitalization time (18.7±8.6 d vs 20.6±7.5 d, t=11.52, P=0.02) and the incidence of acute kidney injury(1/24 vs 5/24, χ2=25.30, P=0.01) in the levosimendan group were lower than those in the dopamine group. There was no statistical difference between the two groups in other early clinical outcomes. At each postoperative time point, there was no statistical difference in creatine kinase isoenzyme (CK-MB) between the two groups. While 6 to 48 hours after operation, there were significant differences in cardiac troponin (cTnI) and brain natriuretic peptide(BNP) level between the two groups (P < 0.05). Five days after operation, the left ventricular ejection fraction(LVEF) in the levosimendan group was higher than that in the dopamine group with statistical difference. ConclusionLevosimendan used for severe valvular disease with atrial fibrillation surgery is safe and effective, and has certain myocardial protection and renal protection effect, while its mechanism still needs further study.

Simultaneous TAVI and McKeown for esophageal cancer with severe aortic regurgitation: A case report

A 71-year-old male presented with esophageal cancer and severe aortic valve regurgitation. Treatment strategies for such patients are controversial. Considering the risks of cardiopulmonary bypass and potential esophageal cancer metastasis, we successfully performed transcatheter aortic valve implantation and minimally invasive three-incision thoracolaparoscopy combined with radical resection of esophageal cancer (McKeown) simultaneously in the elderly patient who did not require neoadjuvant treatment. This dual minimally invasive procedure took 6 hours and the patient recovered smoothly without any surgical complications.