find
Author
"范成中" 5 results
-
There are various examination methods for cardiovascular diseases. Non-invasive diagnosis and prognostic information acquisition are the current research hotspots of related imaging examinations. Positron emission tomography (PET)/magnetic resonance imaging (MRI) is a new advanced fusion imaging technology that combines the molecular imaging of PET with the soft tissue contrast function of MRI to achieve their complementary advantages. This article briefly introduces several major aspects of cardiac PET/MRI in the diagnosis of cardiovascular disease, including atherosclerosis, ischemic cardiomyopathy, nodular heart disease, and myocardial amyloidosis, in order to promote cardiac PET/MRI to be more widely used in precision medicine in this field.
Release date：2020-12-14 05:08
Export
PDF
Favorites
Scan
-
目的 總結甲狀腺功能亢進癥（甲亢）合并2 型糖尿病患者的護理方法。 方法 對2008年3月－2011年10月期間核醫學科收治的20例經131I治療的甲亢伴2型糖尿病患者的臨床治療中的護理進行回顧性分析。 結果 通過131I治療與核醫學科專科護理，20例患者中有18例甲狀腺功能恢復至正常水平或得到改善，12例空腹血糖水平控制在（6.0 ± 1.2）mmol/L，餐后2 h 血糖水平控制在（7.9 ± 1.7）mmol/L。 結論 核醫學科專科護理有助于131I治療甲亢合并2 型糖尿病患者的病情控制，減少并發癥的發生。
-
Cancer is one of the main causes of death for human beings. Clinical oncologists increasingly rely upon imaging for diagnosis, stage, response assessment, and follow-up in cancer patient. However, 18F-FDG is not a tumor specific agent, inflammation and infection also have intensive uptake of 18F-FDG, resulting in false positive diagnosis, and some tumors have low uptake of 18F-FDG or even do not uptake 18F-FDG, leading to false negative diagnosis. So it is urgent to develop non-18F-FDG novel tumor targeting agent. Recently, a large number of researches in vitro have demonstrated that berberine has anti-tumor activity against a variety of tumor cells by inducing tumor cell apoptosis through inhibition of mitochondrial respiratory chain etc. So far, there is no credible evidence of berberine targeting in tumor in vivo. We proposed a hypothesis that berberine has the characteristics of tumor targeting biodistribution in vivo, and verified the proposal by 18F-berberine PET/CT imaging in VX2 muscle tumor-bearing rabbit model. In this review, we intend to give an overview of the progress of berberine anticancer, the structural bases of berberine anticancer and the uderlying molecular mechanisms of berberine anticancer indentified so far. We also introduce the first visualization of 18F labeled berberine derivatives targeting tumor in VX2 muscle tumor-bearing rabbit model by PET/CT. These breakthrough findings suggest that 18F-berberine derivatives as a potential PET/CT tumor targeted molecular imaging agent may have important implications for cancer targeting therapy, molecular imaging and modernization of Traditional Chinese Medicine.
-
[18F]HX-01, a Fluorine-18 labeled berberine derivative, is a potential positron emission tomography (PET) tumor imaging agent, while [19F]HX-01 is a nonradioactive reference substance with different energy state and has the same physical and chemical properties. In order to collect data for further study of [18F]HX-01 PET imaging of hepatocellular carcinomain vivo, this study compared the uptake of [19F]HX-01 by human hepatocellular carcinoma and normal hepatocytesin vitro. The target compound, [19F]HX-01, was synthesized in one step using berberrubine and 3-fluoropropyl 4-methylbenzenesulfonate. Cellular uptake and localization of [19F]HX-01 were performed by a fluorescence microscope in human hepatocellular carcinoma HepG2, SMMC-7721 and human normal hepatocyte HL-7702. Cellular proliferation inhibition and cell cytotoxicity assay of the [19F]HX-01 were conducted using cell counting kit-8 (CCK-8) on HepG2, SMMC-7721 and HL-7702 cells. Fluorescent microscopy showed that the combining ability of [19F]HX-01 to the carcinoma SMMC-7721 and HepG2 was higher than that to the normal HL-7702. Cellular proliferation inhibition assay demonstrated that [19F]HX-01 leaded to a dose-dependent inhibition on SMMC-7721, HepG2, and HL-7702 proliferation. Cell cytotoxicity assay presented that the cytotoxicity of [19F]HX-01 to SMMC-7721 and HepG2 was obviously higher than that to HL-7702. Thisin vitro study showed that [19F]HX-01 had a higher selectivity on human hepatocellular carcinoma cells (SMMC-7721, HepG2) but has less toxicity to normal hepatocytes (HL-7702). This could set up the idea that the radioactive reference substance [18F]HX-01 may be worthy of further development as a potential molecular probe targeting human hepatocellular carcinoma using PET.
Release date：2017-04-13 10:03
Export
PDF
Favorites
Scan
-
目的 探討在正電子發射型計算機斷層顯像/計算機斷層顯像（PET/CT）檢查中護理配合的重要性。 方法 對2012年1月－6月905例行PET/CT檢查者的護理流程及操作規范進行分析總結，并就檢查中的護理要點及配合方法予以逐一闡述。 結果 903例患者順利完成檢查，2例腫瘤骨轉移患者因嚴重疼痛，肌肉注射杜冷丁后仍不能繼續配合檢查而中途放棄。 結論 患者、護士、醫生的通力協作配合，是完成PET/CT檢查并獲得高質量影像資料的重要保證。
Release date：2016-09-07 02:34
Export
PDF
Favorites
Scan
