Objective To investigate the protective effects of antitumor necrosis factor-α antibody （TNF-αAb） on lung injury after cardiopulmonary bypass （CPB） and their mechanisms. Methods Forty healthy New Zealand white rabbits，weighting 2.0-2.5 kg，male or female，were randomly divided into 4 groups with 10 rabbits in each group. In groupⅠ，the rabbits received CPB and pulmonary arterial perfusion. In group Ⅱ，the rabbits received CPB and pulmonary arterial perfusion with TNF-αAb. In group Ⅲ，the rabbits received CPB only. In group Ⅳ，the rabbits only received sham surgery. Neutrophils count，TNF-α and malondialdehyde （MDA） concentrations of the blood samples from the left and right atrium as well as oxygenation index were examined before and after CPB in the 4 groups. Pathological and ultrastructural changes of the lung tissues were observed under light and electron microscopes. Lung water content，TNF-α mRNA and apoptoticindex of the lung tissues were measured at different time points. Results Compared with group Ⅳ，after CPB，the rabbitsin group Ⅰ to group Ⅲ showed significantly higher blood levels of neutrophils count，TNF-α and MDA（P＜0.05），higherTNF-α mRNA expression，apoptosis index and water content of the lung tissues （P＜0.05），and significantly lower oxyg-enation index （P＜0.05） as well as considerable pathomorphological changes in the lung tissues. Compared with group Ⅱ，after CPB，the rabbits in groups Ⅰ and Ⅲ had significantly higher blood concentrations of TNF-α （5 minutes after aortic declamping，220.43±16.44 pg/ml vs.185.27±11.78 pg/ml，P＜0.05；249.99±14.09 pg/ml vs.185.27±11.78 pg/ml，P＜0.05），significantly higher apoptosis index （at the time of CPB termination，60.7‰±13.09‰ vs. 37.9‰±7.78‰，P＜0.05；59.6‰±7.74‰ vs. 37.9‰±7.78‰，P＜0.05），significantly higher blood levels of neutrophils count and MDA （P＜0.05），significantly higher TNF-α mRNA expression and water content of the lung tissues （P＜0.05），and significantly loweroxygenation index （P＜0.05） as well as considerable pathomorphological changes in the lung tissues. Compared with groupⅠ，rabbits in group Ⅲ had significantly higher above parameters （P＜0.05） but lower oxygenation index （P＜0.05） only at 30 minutes after the start of CPB. Conclusion Pulmonary artery perfusion with TNF-αAb can significantly attenuate inflammatory lung injury and apoptosis of the lung tissues during CPB.
Objective To identify the needs of patients undergoing pulmonary nodule day surgery during the perioperative medical interaction experience under the enhanced recovery after surgery mode based on the patient journey map, and to provide references for optimizing the diagnosis and treatment experience of these patients and the patient-centered medical support. Methods Using the descriptive qualitative research method, 15 patients who underwent thoracoscopic pulmonary nodule resection or pulmonary wedge resection in the day surgery ward of Huadong Hospital, Fudan University between January and June 2024 were selected for semi-structured interviews. The data were analyzed using the content analysis method, and the interactive map of the patient’s medical seeking experience was drawn. Results According to the medical seeking process and perioperative stages, the interactive journey map of the patient’s medical seeking experience was formed. The medical seeking experience and health support needs of patients undergoing pulmonary nodule day surgery were classified and summarized into themes such as medical consultation cues, screening of medical information, multidisciplinary assessment, medical-patient cognitive differences, rehabilitation exercises and sports, nutritional management, doctor-patient communication, social adaptation, and emotional expression from four links: interaction touchpoints, information flow, communication methods, and feedback mechanisms. Conclusions Patients undergoing pulmonary nodule day surgery experience the perioperative medical seeking process under the enhanced recovery after surgery mode, with a shortened hospitalization period but complex postoperative health management needs. The interaction touchpoints generated during the experience are intertwined and changeable, and the health support needs required vary at different stages of intervention points. Optimizing the touchpoints can ensure that patients receive efficient medical support when needed, thereby enhancing the patient experience, improving the medical seeking feeling, and ensuring that high-quality nursing services are implemented throughout all stages.
Objective To evaluate the effect of triplex operations (splenopneumopexy, portal azygous devascularization and ligation of splenic artery) for children with extrahepatic portal hypertension. Methods From March 1993 to November 1998, 7 children with extrahepatic portal hypertension underwent triplexoperations. The diagnosis for these patients were confirmed by gastroscopy, barium meal and Doppler ultrasonography. The number of WBCand platelet and the hepatic function were checked before and after operations.And the free portal pressures were checked before and after ligations of the splenic artery. All patients were followed up for 2 to 8 years (5.6 years on average). The episodes of upper gastrointestinal bleeding were recorded. The degrees of varices of distal esophagus and proximal stomach were assessed by barium mealand gastroscopy. The diameters of the splenic and portal veins were obtained byBultrasound. The portopulmonary shunt and portal blood flow were evaluated by color Doppler flow image. The indices of hemorheology such as hematocrit, viscosity of whole blood and plasma, and the index of deformability and aggregability of RBC were obtained through viscometer (R-20 Seerle, Beijing). Results There was no operative fatal case in this group. Postoperatively, hemorrhage from the esophagus and gastric varices was completely controlled. Although the diameter of spleen reduced progressively, no patient’s spleen recovered to normal size during the follow up period. The degree of varices was mitigated and the free portal pressure was significantly decreased to （34.48±5.71） cm H2 O from the preoperative one （42.62±6.72） cm H2 O (P＜0.05). The rate of portal flow was alsodecreased. The direction of portal vein was bidirection (one part was away from the liver and the other was toward the liver). The number of WBC and platelet and the viscosity of whole blood and hematocrit were increased to normal value after operation. Conclusion The triplex operation is an effective procedure for the control of hemorrhage from varices in children with extrahepatic portal hypertension.
Abstract ： Objective To evaluate the clinical validity of Physiological and Operative Severity Score for theenUmeration of Mortality and Morbidity (POSSUM) in primary lung cancer patients undergoing surgery in order to get clinical treatment reference. Methods A total of 179 patients，with 124 males and 55 females，with primary lung cancer surgery between January 2007 and October 2010 were included in the First Affiliated Hospital of Xinjiang Medical University. Their age was 59.2±11.4 years．Before the surgery，POSSUM was used to each patient to rate the results and substituted the results into Copeland equation to calculate the predicted postoperative mortality and morbidity. The actual number of complications and death were calculated after surgery and the patients were divided into one group with postoperative complications and another group without postoperative complications. The physiological score and the operative risk score were compared between the two groups. Actual number of complications and death were compared with thenumber predicted by POSSUM respectively. The clinical factors related to the actual number of complications and death were analyzed. Results Among 179 patients， there were postoperative complications in 78 patients. The physiological score and the operative severity score were significantly higher in the group in whose complications occurred compared with those without complications (16.11±2.53 points versus 14.88±1.86 points for physiological score，P=0.000 ； 13.47±2.83 points versus 12.88±2.57 points for operative severity score，P=0.000). There was no statistical difference in complication between the predicted and actual number (65/179 versus 78/179，χ2=1.968，P=0.161). There was statistical difference in death between the predicted and actual number(12/179 versus 3/179，χ2=5.636，P=0.018).Univariable analysis revealed that 5 single factors were related to the complications， only hemoglobin was related to the death. Conclusion The POSSUM gives satisfactory prediction in morbidity rate but overrates the mortality rate in primary lung cancer patients undergoing surgery， and 5 single clinical factors show a better clinical value.
目的:探討慢性阻塞性肺疾病(COPD)合并糖尿病患者的肺功能及血氣分析特點并分析其臨床意義。方法:選取2008年1月~2009年1月在我院門診就診的穩定期患者53例作為研究對象,并根據是否合并糖尿病分為COPD合并糖尿病組26例,單純COPD組27例,并通過肺功能檢測及血氣分析,檢測肺活量 (VC)、用力肺活量 (FVC)、第1秒鐘用力呼氣容積 (FEV1)、 FEV1/用力肺活量 (FVC)、用力呼氣中期流速PEF(25%～75%) 、肺一氧化碳彌散(DLCO)及肺一氧化碳彌散量實測值占預計值的百分比(DLCO /PRED)等肺功能指標及PaO2、PaCO2等血氣指標,并進行組間分析。結果:COPD合并糖尿病組肺通氣功能指標VC、FVC、FEV1、PEF(25%～75%)和彌散功能指標DLCO、DLCO/PRED及PaO2顯著低于單純 COPD組。結論:COPD合并糖尿病時肺通氣功能和彌散功能都可受損。
Objective To evaluate the sonographic characteristics of peripheral focal inflammation of lung, and to improve the diagnosis and differential diagnosis potency of sonography for pulmonary peripheral lesions. Methods The sonogram of 44 patients with peripheral focal inflammation of lung were retrospectively analyzed and compared with the sonogram of other lesions. Independent variables included lesion’s margin, echotype, the secondary change of visceral pleura, the angulation of lesion’s inner surface and air bronchogram. Lesion’s nature was as dependent variable. The data was analyzed by Logistic regression analysis. Pathological results were confirmed by biopsy. Results The angulation of lesion’s inner surface and air bronchogramwere significant factors affecting the diagnosis of peripheral focal inflammation of lung( P lt;0. 01) . Compared to the pathological yield by biopsy, angulation of lesion’s inner surface being acute angle for diagnosis of peripheral focal inflammation of lung had an accuracy rate of 82. 6% , a sensitivity of 72. 7% , a specificity of 84. 7% , a positive predictive value of 51. 0% , and a negative predictive value of 93. 4%. Conclusions The acute angle of lesion’s inner surface and air bronchogram are sonographic characteristics of peripheral focal inflammation of lung. Bedside lung ultrasound is useful to the diagnosis of peripheral focal inflammation of lung.
Objective To investigate the risk factors of chronic obstructive pulmonary disease (COPD) combined with obstructive sleep apnea (OSA) and its relationship with apnea-hypopnea index (AHI). Methods Clinical data of 216 COPD patients with OSA were retrospectively chosen in the period from January 2016 to December 2019 in our hospital. All patients were divided into different groups according to with or without OSA and the clinical features of patients with and without OSA were compared. Multivariate analysis was used to analyze the influencing factors of COPD with OSA and the correlation between AHI and COPD with OSA was also evaluated. Results ① The age, body mass index (BMI), neck circumference, smoking index, forced expiratory volume in 1 second (FEV1), FEV1% predicted (FEV1pred), the ratio of FEV1 to the forced vital capacity of the lungs (FEV1/FVC), COPD assessment test (CAT) score, Epworth sleepiness scale (ESS) score, Charlson comorbidity index (CCI) score, sleep apnea clinical score (SACS) score and proportion of patients with essential hypertension in OSA group were significantly higher than non-OSA group (P<0.05). The course of disease and the proportion of severe COPD and GOLD grade 4 in OSA group were significantly less than non-OSA group (P<0.05). ② AHI was positively correlated with age, BMI, neck circumference, smoking index, FEV1%pred, FEV1%pred<50%, CAT score, ESS score, CCI score and SACS score (P<0.05); and negatively correlated with FEV1%pred<50% (P<0.05). ③ Multivariate analysis showed that BMI, FEV1%pred<50%, CAT score and ESS score were the independent factors of COPD patients with OSA (P<0.05). ④ The proportion of AHI<5 times/h in GOLD grade 4 was significantly higher than GOLD grade 1-3 (P<0.05). The proportion of AHI> 30 times/h in GOLD grade 4 was significantly lower than GOLD grade 1-3 (P<0.05). Conclusion The incidence of COPD with OSA was independently correlated with BMI, FEV1%pred, CAT score and ESS score; patients with severe COPD possess lower OSA risk.