ObjectiveTo investigate the optimal catheter extubation time by comparing the postoperative complications in elderly patients undergoing total hip arthroplasty with catheter extubation at different times. MethodsBetween May and August 2013, 60 patients needing total hip replacement were randomly divided into experimental group and control group with 30 in each. The patients' average age of the experimental group was 75.6 years (65-87 years) and of the control group was 76.9 years (66-85 years). Extubation was performed within 24 hours after surgery in the experimental group, while it was performed after 24 hours after surgery in the control group. All the patients underwent clean catheterization with a Foley catheter two hours before surgery. The catheter indwelling time, first time of self-urination, urination after extubation, and complications were recorded and compared between the two groups carefully. ResultsThe incidence of complications (urinary retention, urethral pain, cystospasm and urinary irritant symptoms) in the experimental group was significantly less than the control group (P<0.05). The first urination time had no significant difference (P>0.05) between the two groups. ConclusionThe extraction of indwelling catheter in the early postoperative period (within 24 hours) can reduce the incidence of complications and is better for the early postoperative rehabilitation.
Objective To explore the relationship between different diagnostic criteria (ATPIII2002, IDF2005 and CDS2007 criteria) for metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD). Methods A total of 666 elderly males admitted to West China Hospital for routine physical examination were involved in this study in May, 2010. The diagnostic agreement rates of different criteria were compared, along with the relationship between different diagnostic criteria for MS and NALFD. Results The diagnostic agreement of CDS2007 criteria with either IDF2005 or ATPIII2002 criteria was good. However, the agreement of ATPIII2002 with IDF2005 was compromised. The prevalence of NAFLD in MS group was significantly higher than that of non-MS group (Plt;0.01). On the basis of CDS2007 criteria, there was significant correlation between NAFLD and MS (Plt;0.000). Conclusion There is a close relation between NAFLD and all three diagnostic criteria of MS. NAFLD is one of the most important risk factors of MS. The diagnostic agreement of CDS2007 criteria with the other two is good, and there is significant correlation between NAFLD and criteria CDS2007 of MS. CDS2007 is found to be of high accuracy and applicability in the diagnosis of MS in Chinese population including the elderly.
目的 觀察與分析體重異常老年男性血清前列腺特異性抗原（T-PSA）與生長激素（GH）水平及影響因素。 方法 以2009年1月－2012年6月，血清GH＜5 ng/mL、血清T-PSA＜4.5 ng/mL的老年男性共296例作為觀察對象，依據體質量指數分為低體重組、正常體重組、超重組及肥胖組。依據年齡分為60～64、65～69、70～74及≥75歲四組。測定296例入選對象的血清T-PSA及GH并進行分析。 結果 隨著年齡增長，血清T-PSA、GH漸增高。≥75歲年齡組血清T-PSA高于其他三組，差異無統計學意義（P＞0.05）。≥75歲年齡組血清GH高于其他三組，差異有統計學意義（P＜0.01）。超重組及肥胖組血清T-PSA低于正常體重組，差異有統計學意義（P＜0.01）。低體重組血清T-PSA稍低于正常體重組，差異無統計學意義（P＞0.05）。肥胖組血清GH低于超重及正常體重組，差異無統計學意義（P＞0.05）。低體重組血清GH低于正常體重組，差異無統計學意義（P＞0.05）。單因素相關分析顯示血清T-PSA與年齡、GH正相關；與BMI負相關；與收縮壓（SBP）、舒張壓（DBP）、空腹血糖（FPG）及血脂不相關。血清GH與年齡、T-PSA、SBP、DBP正相關；與BMI、FPG及血脂不相關。校正年齡、BMI后，血清T-PSA與GH仍呈正相關。 結論 隨著年齡增長，老年男性血清T-PSA、GH漸增高。老年男性非肢端肥大癥者血清T-PSA與血清GH水平及BMI有關聯，血清GH水平較高者，血清T-PSA也較高；血清T-PSA與BMI負相關。
Objective To study the effectiveness, safety and tolerance of testosterone undecanoate （TU） in improving exhaustion and quality of life （QOL） of the elderly male patients with chronic disease in advanced stage. Methods Using a simple randomized controlled trial design, eighty patients were randomized into two groups. The treatment group took routine therapy and TU and the control group with routine therapy alone. Results 1. Baseline characteristics in both groups were similar. 2. The PADAM grade decreased, and the QOL scale increased in the treatment group （P〈0.05 ）. 3. Serum total testosterone in the treatment group rose, upper arm circumference and right hand grip improved （P〈0.05 ）. 4. There were no significant differences in adverse effects between both groups. Conclusions TU can improve the clinical health status in the elderly male patients with chronic disease in advanced stage and increase serum testosterone level, there is a satisfactory tolerances and few adverse reactions.
ObjectiveTo analyze the effects of alcohol consumption on oral flora of middle-aged and elderly men from the core area of southwestern China, and explore the relationship between excessive-alcohol-consumption-related flora and alcohol-related cancer.MethodsFrom March to June 2018, saliva samples of target subjects were collected for 16S ribosomal RNA gene sequencing, and a questionnaire survey which took drinking history of each participant as the target variable was conducted. According to the amount of alcohol consumed, the subjects were divided into non-drinking group, moderate-drinking group, and excessive-drinking group. The microbial analysis of α diversity, analysis of group difference of oral flora abundance, bacterial function prediction, and receiver operating characteristic (ROC) curve model prediction were carried out.ResultsA total of 59 subjects were included. There were 23 cases (39.0%) in the non-drinking group, 23 cases (39.0%) in the moderate-drinking group, and 13 cases (22.0%) in the excessive-drinking group. The average age was (61.90±8.85) years. Excessive drinking increased the abundance of oral flora (P<0.05), and could change the abundance of specific genus such as Peptostreptococcus and TM7［G-6］ (P<0.05) and regulate cancer-related pathways (P<0.05). ROC analysis found that a panel of three genus oral bacteria such as TM7［G-6］ might effectively distinguish the non-drinking group from the excessive-drinking group (area under curve=0.915).ConclusionsGenus of Peptostreptococcus and TM7_［G-6］ are the potential oral flora biomarkers for the excessive-drinking of target subjects. Some excessive drinking-related flora are closely related to oral cancer.