Resuming oral anticoagulant (OAC) after intracerebral hemorrhage (ICH) is still a dilemma to clinical decision. To date, no high-quality randomized controlled trials demonstrate the timing and mode of safely resuming OAC. In recent years, some moderate-quality researches have suggested that OAC resuming after ICH can decrease the incidence of thromboembolic events and long-term mortality, without significantly increasing the risk of ICH; it is safer to resuming OAC in patients with non-lobar ICH than in patients with lobar-ICH; new OACs are superior to vitamin K antagonists; patients with high thromboembolic risk should resume OAC 2 weeks or even earlier after ICH, otherwise, a time-window for optimal resumption is between 4-8 weeks; meanwhile, individual patient characteristics should be considered and blood pressure should be strictly controlled.
Cardiac rehabilitation can safely and effectively improve the quality of patient's life and reduce readmission rate and mortality after cardiac surgery. Early cardiac rehabilitation after cardiac surgery is an indispensable part of cardiac rehabilitation. It can speed up the recovery of patient's exercise endurance, prevention of postoperative complications, shorten the time of returning to the family, increase the confidence of sustained rehabilitation, and lay foundation and set rehabilitation targets for the later stage of cardiac rehabilitation. This paper reviews the development history of early cardiac rehabilitation after cardiac surgery, and summarizes the current status, problems and outlook of rehabilitation management in China.
Objective To investigate the influencing factors on the promotion and appointment of reserve management talents in public hospitals, providing references for the full-cycle management of these talents. Methods A case-control study was conducted on reserve management talents at West China Hospital of Sichuan University from 2016 to 2023 to explore factors associated with their promotion and appointment. Results A total of 348 reserve management talents were included, with 102 in the promoted group and 246 in the non-promoted group. Univariate analysis revealed that age, academic degree, length of hospital service, employment type, professional title, supervisor type, and whether serving as a medical team leader were significantly associated with promotion (P<0.05). Multivariate logistic regression analysis revealed that reserve management talent category [part-time project supervisor vs. part-time dean’s assistant: odds ratio (OR)=0.050, 95% confidence interval (CI) (0.004, 0.594), P=0.018], doctoral degree [OR=9.279, 95%CI (2.626, 32.792), P=0.001], >10 years of hospital service [OR=3.598, 95%CI (1.892, 6.842), P<0.001], and supervisor type [master’s supervisor vs. non-supervisor: OR=2.234, 95%CI (1.148, 4.349), P=0.018; doctoral supervisor vs. non-supervisor: OR=7.604, 95%CI (2.882, 20.061), P<0.001] as independent predictors of promotion. Conclusion Reserve management talent category, advanced academic degrees (doctorate), longer service duration (>10 years), and qualification as a graduate supervisor are independent predictors of promotion to management positions, highlighting the competitive advantage of candidates with academic credentials, practical experience, and competencies in both teaching and administration.
ObjectiveTo investigate the relationship between glucose metabolism and endocannabinoid system (ECS) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS).MethodsA total of 64 OSAHS patients (18 cases of mild OSAHS, 24 cases of moderate OSAHS, 22 cases of severe OSAHS) and 24 controls were included in the study. Body mass index, waist circumference, fasting blood lipids, fasting blood glucose, fasting blood insulin, homeostasis model of assessment for insulin resistance index (HOMA-IR), polysomnography and endogenous cannabinoid receptor 1 (CB1R) protein expression levels in peripheral blood mononuclear cells (PBMC) were measured in participants.ResultsThe incidence of diabetes and impaired fasting glucose (IFG) in the OSAHS group was significantly higher than that in the control group (28.12% vs. 8.33%). With the increase of apnea hypopnea index (AHI), HOMA-IR and the expression levels of CB1R protein increased gradually (HOMA-IR: 2.40±0.90, 2.34±0.59, 2.94±0.99, 3.46±0.77, respectively; CB1R protein: 0.04±0.01, 0.37±0.09, 0.40±0.07, 0.62±0.14, respectively). Correlation analysis showed that HOMA-IR, AHI and the expression of CB1R protein were significantly positively correlated with each other (P<0.05).ConclusionOSAHS patients are prone to insulin resistance, IFG and diabetes mellitus, which are closely related to the activation of ECS induced by OSAHS.
Medical aid to Xinjiang is an important task for large public hospitals in China. The innovative mode of team aiding in medical aid program for Xinjiang has played an important role in the national aid-Xinjiang program. West China Hospital of Sichuan University is actively exploring an aid-Xinjiang mode which combines medical aid of multi-disciplinary teams collaborated by doctors, nurses, medical technicians, and management teams with scientific and technological aid; based on the reality of Xinjiang medical healthcare, promoting the overall improvement of medical care through multi-disciplinary integration of resources; and relied on big data, promoting the innovative development of scientific and technological aid to Xinjiang. It is of great practical significance to summarize the work of medical aid to Xinjiang in West China Hospital of Sichuan University over the years and to put forward suggestions for the generalization and popularization of the medical aid to Xinjiang mode.