The sonographic features of male breast lesions, which underwent ultrasound examination in our hospital for the past 10 years, were retrospectively analyzed. Sonographic features of these lesions were standardized as BI-RADS image lexicon. The differences in ultrasonic malignant signs were assessed between the benign and the malignant diseases. Between the two groups, incomplete boundary was statistically different. The specificity was above 95% within the two groups in terms of speculated margin, echogenic halo, calcification, axillary lymphadenopathy, thickening of skin and eccentric of mass to the nipple. High-frequency sonographic examination has a high level of differential diagnosis for male breast lesions.
ObjectiveTo summarize the research progress of the cause, treatment, and other aspects in male breast cancer (MBC). MethodsThrough reading the related literatures, relevant literatures of MBC were reviewed. ResultsFamily history, BRCA1/2 mutation, the imbalance of level of estrogen and androgen, and other factors were risk factors of the MBC. Sentinel lymph node biopsy (SLNB) was feasible in the MBC. Radiotherapy could control local recurrence of MBC, and chemotherapy may be beneficial for long-term survival rate of MBC. The endocrine therapy principle for MBC was not exact as female breast cancer (FBC). ConclusionsMBC has many risk factors. Radiotherapy, chemotherapy, and endocrine therapy are benefit to MBC patients, but it still needs to be confirmed by many high-quality clinical researches of large sample.
目的 初步探討影響男性乳腺癌患者預后的因素。 方法 收集2003年1月－2011年12月經病理確診、接受治療、臨床資料較完整的36例男性乳腺癌患者的臨床資料。采用對數秩檢驗和Cox回歸分析影響男性乳腺癌患者預后的因素。 結果 36例患者無進展生存期（PFS）為3～95個月，中位PFS為45個月。單因素分析顯示：腫瘤直徑（P=0.001）、陽性淋巴結（P=0.001）、TNM分期（P＜0.001）、手術方式（P=0.001）是影響預后的因素。多因素分析顯示：陽性淋巴結（P=0.024）和TNM分期（P=0.022）是影響預后的主要因素。 結論 陽性淋巴結和TNM分期是影響預后的主要因素，以手術為主的綜合治療模式是提高男性乳腺癌患者生存率的重要措施。
Objective To investigate the relationship between skin/pectoral muscle invasion and the prognosis of male breast cancer. Methods Clinical data and follow-up information of 79 male breast cancer patients who received treatment between September 2008 to April 2020 in West China Hospital were retrospectively reviewed, to analyze the clinicopathological features of male breast cancer and prognostic value of skin/pectoral muscle invasion. Results Among 79 male breast cancer patients, a total of 23 patients (29.1%) were with skin/pectoral muscle invasion at diagnosis. All the patients were followed up, with a median follow-up period of 63.3 months (1.0–204.5 months). Within follow-up period, 8 patients (10.1%) suffered from relapse, 19 patients (24.7%, 19/77) suffered from metastasis, and 4 patients (5.1%) died. Multivariate Cox proportional risk regression model suggested that patients with skin/pectoral muscle invaded had poor disease free survival [RR=4.48, 95%CI (1.08, 18.52), P=0.038]. Conclusions Skinor pectoral muscle invasion might be a valuable prognostic factor for male breast cancer patients. However, limited by sample size, the conclusion should be proved by further high-level studies.
ObjectiveTo summarize the progress of diagnosis and treatment in male breast cancer. MethodsThe literatures about the research progress of diagnosis and treatment in male breast cancer were reviewed. ResultsThe diagnosis of male breast cancer relied mainly on clinical manifestations and imaging manifestations, the main treatment of male breast cancer was modified radical operation, combining with radiotherapy, chemotherapy, endocrine therapy, and targeted therapy. ConclusionsThe treatment of male breast cancer is mainly reference the treatment of female breast cancer, which is lack of a clear standard of treatment. Indepth study on the molecular genetic level will provide more accurate care decisions for the treatment of male breast cancer.
目的 對19例男性乳腺癌的發病情況及診治過程和結果進行回顧性總結。方法 選擇我院1973年至1997年收治的19例男性乳腺癌患者，并對其發病特點及診治情況、預后進行分析。結果 男性乳腺癌發病率低(1.2%)，發病年齡高，平均55歲，病程長，平均3.75年，病理類型均為浸潤型。治療均采用手術切除，加術后放、化療及內分泌治療。結論 男性乳腺癌較少見，病程長，惡性程度高，預后差。由于其在臨床表現上無特異性，故極易被忽視或誤診。由于上述特點，要提高男性乳腺癌的存活率，早期診斷及治療就顯得尤為重要。