Pleuropulmonary blastoma (PPB) is a kind of rare malignancy which often occurs in children and is related to dysplasia. It always involves in pleura and lung. PPB is misdiagnosed easily because of its special pathophysiological characters and complex biological behavior. Early detection and correct treatment are very important for thoracic surgeon to cure PPB. This paper reviews the advance of pathophysiological characters, molecular genetic characters, clinical manifestation, clinical diagnosis and differential diagnosis, and treatment and prognosis of PPB.
In order to protect the integrity and function of the digestive system, duodenum-preserving total pancreatic head resection is becoming the surgical method which was chosen by more and more doctors for benign lesions or low-grade malignant tumors of the pancreatic head. With the development of minimally invasive concepts and techniques, laparoscopic technology has brought unique advantages to this surgery. In this paper, a series of problems such as the development process and indications of laparoscopic duodenum-preserving total pancreatic head resection were discussed, and the core techniques of surgery and how to reduce the occurrence of complications were emphasized. The aim is to improve the therapeutic effect and quality of life of patients through reasonable surgical methods and treatment strategies.
Objective To observe the action and correlation of p16 and estrogen receptor (ER) in papillary thyroid cancer (PTC).Methods Using immunohistochemical method, the p16 and ER in 50 cases of PTC were detected. Results The expression of p16 and ER was associated with the cellular differentiation, the lymphatic metastasis and prognosis in PTC. Conclusion It is helpful to detect the p16 protein and ER for analyzing the cellular differentiation degree and prognosis in PTC.
Objective To investigate the possibility of using extendible distal femoral replacements in the treatment of osteosarcoma in growing individuals. Methods From December 1999 to March 2003, 3 cases (2 were typeⅡB, 1 was type ⅡA) with osteosarcoma were treated byextendible distal femoral replacements. Of the 3 cases, 2 underwent prosthesis extention operation, 1 was not operated. Results After the removal of tumor, the extremities of 2 patients were shortened by 4 to 5 cm within 2 to 3 years. After the lengthening procedure, the affected extremities were of equal length to the unaffected extremities and no drag symptoms of blood vessel and nerves were observed. Follow-up was done for 2 months to 3 years. There was no aseptic loosening. The function of joints was fairly good. Conclusion Extendible distal femoral replacements is an easy, convenient, and effective way to treat osteosarcoma.
Objective To investigate the early diagnosis and effective treatment of Fournier syndrome. Methods The clinical data of 385 patients with perianal abscess in this hospital between 2006 and 2009 were retrospectively analyzed for screening the patients with complication of Fournier syndrome. Results Fournier syndrome was detected in 6 patients （1.56%）， who were all cured by treating with early incision and drainage, complete debridement, effective antibiotics, and supporting therapy. Conclusions Perianal abscess can induce Fournier syndrome of perineal, genital, and abdominal wall regions, which spreads rapidly and progressively, so early diagnosis and extensive surgical debridement play a decisive role on the prognosis.
Objective To assess the short-term effect of the mini-invasive surgical method by Achillon in repair of acute achilles tendon rupture. Methods Between December 2009 and February 2010, 11 patients (11 feet) with acute achilles tendon ruptures were treated, including 8 males (8 feet) and 3 females (3 feet) with an average age of 35.4 years (range, 23-58 years). There were 9 cases of jump injury, 1 case of glass cut injury, and 1 case of fall injury. The results of Thompson testwere positive in 11 cases (11 feet). According to the American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfootscoring system, the score was 53.19 ± 6.31. MRI indicated that the gap of the acute achilles tendon rupture was 1-5 cm (3.8 cm on average). The interval between injury and operation was 2-7 days (3.6 days on average). An approximately longitudinal 3- 4 cm incision was performed and the ruptured achilles tendon was repaired by use of Achillon. Early rehabil itation was carried out. Results The operation time was 27-58 minutes (38 minutes on average). The hospital ization time were 2-3 days (2.5 days on average). Superficial wound infections occurred in 2 cases, and wound healed after dressing change; orther incision healed by first intention. All the patients were followed up 5-8 months with an average of 6.7 months. No wound problems, sural nerve injuries, or re-ruptures occurred in the other cases. After a 3-month follow-up, all patients were able to return to normal walking. The AOFAS ankle-hindfoot score was 94.32 ± 4.23, showing significant difference when compared with that before operation (P lt; 0.05). Conclusion The technique with Achillon offers patients a safe procedure for repair of acute achilles tendon ruptures and early active rehabil itation can be carried out.
ObjectiveTo summary the diagnosis and surgical treatment experiences of posterior collicular fracture of medial malleolus. MethodsBetween March 2008 and November 2010, 14 patients having lateral and (or) posterior malleolus fractures with posterior collicular fracture of medial malleolus were treated with open reduction and internal fixation, including 5 males and 9 females with an average age of 44.5 years (range, 27-60 years). The causes of injuries were strain in 9 cases, traffic accident in 3 cases, and falling from height in 2 cases. The course of fracture ranged from 3 to 9 days (mean, 6.5 days). Fourteen cases were lateral malleolus fractures, 10 cases were posterior malleolus fractures. According to Lauge-Hansen classification, there were 8 cases of pronation-external rotation type, 3 cases of pronation-abduction type, and 3 cases of supination-external rotation type. ResultsAll incisions healed by first intention with no complication. The patients were followed up 12-24 months (mean, 16.8 months). The X-ray films showed that all fractures healed from 2 to 4 months after operation (mean, 2.9 months). The range of motion (ROM) of affected ankles was (38.40 ± 3.50)° of flexion and was (16.30 ± 2.41)° of extension, showing no significant difference when compared with ROM of normal side [(40.50 ± 3.48)° and (17.90 ± 2.28)°, P gt; 0.05]. All patients’ ankle function was evaluated by Olerud-Molander’s score criteria for ankle function evaluation, the results were excellent in 7 cases, good in 6 cases, and fair in 1 case. ConclusionSpiral CT plays an indispensable role in diagnosis of posterior collicular fracture of medial malleolus. Surgical reduction and rigid fixation should be performed.
【Abstract】Objective To explore the feasibility that the recipient against donor antigen-specific T lymphocytes clones are formed,and the suicide genes are induced into the clone. In the end it may induce the transplanted-organ tolerance. Methods The recipient rats were immunized by the donor rats-splenocytes, then the recipient’s T cell were isolated, purified and diluted with limited-dilute methods into single cell.The T cells were cultured by adding raise cells,ConA or IL2 under the different concentration and at last the T cell clone were formed. Results A stable recipient against donor antigen-specific T cell clone was established. The difference among the different immune groups was very significant(tgt;t0.05). The T cell clone was not formed without raise cells or only with raise cells. The rare clone could be formed by ConA stimulation but without IL-2. The clone-forming rate was associated with concentration of IL-2. ConclusionThe mature T cell is able to proliferate to form clone when the condition is suitable. The recipient is immunized with donor rats spleen cellular antigen. The T cells clones selected in the end are donor antigen-specific.