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    find Author "王玲" 31 results
    • Effect of background light intensity on the slow components and the oscillatory potentials of the electroretinogram

      Objective To study the response of the retinal neuronal adaptive system to changes of background illumination (BG) by measuring the oscillatory potentials (OPs) and the a- and b-waves of the electroretinogram (ERG) in different BG illuminations. Methods The a- and b-wave and the digitally filtered OPs were simultaneously recorded from Wistar Fu rats aged from 25 to 29 days during dark adaptation (DA) and during 6~8 minutes of BG illuminations at four levels increased successively by steps of two log units, i.e., ldquo;low scotopicrdquo; level of 1.43times;10-6cd/m2, ldquo;high scotopicrdquo; of 1.43times;10-4cd/m2 , ldquo;low mesopicrdquo; of 1.43times;10-2cd/m2 and ldquo;high mesopicrdquo; of 1.43times;10-2cd/m2. Full field stimulus flashes of 75 msec duration and 1.43times;10-2cd/m2intensity was delivered at an interval of 1 minute. Results Five OP wavelets were recorded in DA and during scotopic BG illuminations. The number of wavelets was reduced to three as the eyes were exposed to mesopic BG levels. However, the sum of OPs amplitudes (SOPs) increased as the BG was intensified, except at ldquo;high mesopicrdquo; level, by which a significant decrease of SOPs occurred. The amplitudes of the a-and b-waves remained unchanged at the two scotopic BG and decreased as the BG intensity increased to mesopic levels. Conclusion The response of retinal neural adaptive system of the Albino rat to changes of BG light is more sensitive and robust than the slow components of the ERG. The enhancement of the oscillatory responses at ldquo;low mesopicrdquo; illumination level suggests that using proper BG light may be conducive to reducing the variation of OPs.  (Chin J Ocul Fundus Dis, 2001,17:286-288)

      Release date:2016-09-02 06:03 Export PDF Favorites Scan
    • Management and prognosis of constrictive pericarditis during pericardiectomy

      Objective To estimate the relationship of methods and drugs for management of constrictive pericarditis during pericardiectomy. Methods We reviewed the records of 45 patients (mean age, 40.24±15.34 years) with a diagnosis of constrictive pericarditis who underwent pericardiectomy in our hospital from 2012 through 2014 year. During operation, inotropic agents, vasodilators and diuretics were used. According to the diuretics, patients were divided into two groups including a furosemide group(group F) with 38 patients and a lyophilized recombinant human brain natriuretic peptide (lrhBNP) group with 7 patients(group B). Results Preoperatively, 30 patients were pulmonary congestion, which was diagnosed by chest radiographs. Pericardiectomy was finished by off pump in 43 patients. Another 2 patients required cardiopulmonary bypass (CPB) for pericardiectomy. In the group F 52.6% of the patients needed vasodilators to reduce cardiac preloading following pericardiectomy. None of other vasodilators were used in the group B. After pericardiectomy, the fluctuation of systolic and diastolic pressure decreased significantly in the group B (P=0.01, respectively). In the group F, the fluctuation of diastolic pressure decreased significantly (P<0.05). Low cardiac output was the most common postoperative problem. One patient accepted postoperative extracorporeal membrane oxygenation (ECMO) support. Postoperative poor renal function was found in 42.2% of the patients. Three of them needed hemofiltration. Postoperative poor renal function accompanied by poor hepatic function was found in 15.6% of the patients. One of them used dialysis and artificial liver. Three patients were respiratory failure with longer mechanical ventilation and tracheotomy. The overall perioperative mortality rate was 6.7% (3 patients). All patients, who died or used with hemofiltration, artificial liver and ECMO were found in the group F. Conclusion More stable haemodynamics after pericardiectomy may occur with using lrhBNP. lrhBNP may reduce postoperative major morbidity and mortality. Because of the small group using lrhBNP in our study, more patients using lrhBNP for pericardiectomy need to be studied.

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    • 特發性震顫的遺傳學研究進展

      特發性震顫(essential tremor,ET)是最常見的成年起病的神經系統變性疾病之一。ET 分為家族性和散發性 2 種,約一半以上患者存在家族史,遺傳因素可能發揮著重要作用。目前,大量研究致力于尋找 ET 發病的風險位點及致病基因。進行 ET 遺傳學分析有助于進一步研究其病理生理機制,因此文章從該病的單基因遺傳模式及復雜疾病遺傳模式 2 個方面對 ET 的遺傳學進展進行了闡述。

      Release date:2017-05-18 01:09 Export PDF Favorites Scan
    • 經顱磁刺激在帕金森病患者步態異常中的應用

      經顱磁刺激(TMS)是利用變化的高毫安電流產生變化的磁場誘導的感應電場作用于顱內可興奮組織的過程。TMS以其可進行深部刺激、無痛、非介入等優點,被廣泛地應用于帕金森病的研究和治療中。目前帕金森病患者步態異常發生的病理生理機制尚不清楚,且治療十分困難。近年來TMS在對帕金森病患者步態異常的研究中得到了較大的進展。現對TMS原理以及在帕金森病患者步態異常研究及治療中的應用和進展進行綜述。

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    • Information System for Causauty Management in Major Natural Disaster

      目的:信息系統的改進應用是為確保急診科預檢分診處將來能使醫院對自然災害事件的傷員救治時以最便捷、最快速的方式錄入自然災害事件傷員的信息資料和快速評估傷情,優先準確的將傷員按病情和就診區域分類,以便暢通及時救治傷員;在治療中和日后便于識別、查找、統計災害事件傷員。方法:LIS(檢驗系統)+ RIS(影像系統)+ HIS(無紙化辦公系統)三合一系統和增加自然災害傷員的“錄入信息資料”眉欄。結果:進一步改進信息網絡應用系統后,能滿足一般患者信息資料錄入和自然災害事件應急狀況下的患者資料錄入,實現電子病歷和電子處方等信息網絡系統,達到院內、科內資源共享。

      Release date:2016-08-26 03:57 Export PDF Favorites Scan
    • Study on macular retinoschisis by optic coherence tomography in eyes with high myopia

      Objective To observe the the clinical characteristics of images of optic coherence tomography (OCT) in highly myopic eyes with retinoschisis. Methods The clincial data of 158 patients (158 eyes) with high myopia diagnosed by examinations of best corrected visual acuity and refraction, indirect stereoscopic ophthalmoloscopy, A/Bscan ultrasonography, and OCT, were retrospectively analyzed. The patients were divided into retinoschisis group and nonretinoschisis group according to the results of OCT (whether the patients had macular reinoschisis at the posterior pole). There were 53 patients (55 eyes, 34.8%) in the former group, and 101 patients (103 eyes, 65.2%) in the latter group. The age, sex, diopter, visual acuity, ocular axial length, and incidence of posterior scleral staphyloma, vitreous traction, and retinal detachment of the two groups were compared. Results B-scan ultrasonography showed posterior scleral staphloma in all of the 158 eyes. OCT indicated that in the 55 eyes in the retinnoschisis group, 15 (27.3%) had inner, 53 (96.4%)had outer, and 7 (12.7%)had middle retinoschisis. The inner and outer one could exist independently or in the same eye, while the middle one was always accompanied by the outer retinoschisis. Two or more types of schisis coexisted in 13 eyes (23.6%), single outer retinoschisis was found in 40 eyes (72.7%), and single inner retinoschisis was found in 2 eyes (3.6%). There were 26 eyes(47.3%)were accompanied with retinal detachment, 13 eyes(23.6%) with macular hole, and 12 eyes (21.8%)with vitreous traction. In the 103 eyes in the nonretinoschisis group, 23 eyes (22.3%)had vitreous traction, 19 eyes (18.4%) had macular hole, and 21 eyes (20.4%)had retinal detachment. The differences of age, diopter and ocular axial length, sex, incidence of macular hole and vitreous traction between the two groups were not statistically significant (Pgt;005). The visual acuity in retinoschisis group was much lower than that in the nonretinoschisis group (Plt;005), and the difference of incidence of the retinal detachment between the two groups was significant (Plt;001). 〖WTHZ〗Conclusion 〖WTBZ〗Macular retinoschisis in eyes with high myopia can exist in inner or middle retina, but most of them locate at outer retina.The patients always have poor visual acuity and are often accompanied by other macular lesions such as retinal detachment.

      Release date:2016-09-02 05:43 Export PDF Favorites Scan
    • 鞘脂生物合成調節因子 3與支氣管哮喘的相關性及其研究進展

      Release date:2024-01-06 03:59 Export PDF Favorites Scan
    • Diagnostic value of ultrasound for fracture of the distal radius and ulna: a systematic review

      Objective To systematically review the value of ultrasound in the diagnosis of fracture of the distal radius and ulna for providing evidence for clinical diagnosis. MethodsWe searched PubMed, EMbase, The Cochrane Library (Issue 7, 2016), CNKI, CBM and WanFang Data databases for studies about ultrasound in the diagnosis of fracture of the distal radius and ulna from inception to August 1st, 2016. Two reviewers independently screened literatures according to inclusion and exclusion criteria, extracted data, and assessed the risk of bias of included studies by using the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies 2) tool, and then meta-analysis was performed by using Meta-Disc 1.4 software. ResultsA total of 16 articles involving 1 182 patients and 631 fractures were included. The results of heterogeneity test revealed that there was statistical heterogeneity among the results of studies, thus, random effects model was used for meta-analysis. The results of meta-analysis showed that the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnosis odds ratio for ultrasound diagnosis fracture of the distal radius and ulna were 0.95 (95%CI 0.94 to 0.97), 0.92 (95%CI 0.89 to 0.94), 9.98 (95%CI 5.20 to 19.15), 0.07 (95%CI 0.04 to 0.13), 187.94 (95%CI 65.67 to 537.84), respectively. The area under the SROC curve was 0.976 4. ConclusionUltrasound is a useful non-invasive method as a routine examination for fracture of the distal radius and ulna. Due to the limited quality and quantity of included studies, the above conclusion is needed to be validated by more high-quality studies.

      Release date:2017-02-20 03:49 Export PDF Favorites Scan
    • 血紅素氧合酶對鼠視網膜缺血再灌注損傷的保護作用

      Release date:2016-09-02 05:48 Export PDF Favorites Scan
    • 近視眼與視網膜周邊部退行性病變

      Release date:2016-09-02 06:01 Export PDF Favorites Scan
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