目的 探討胰腺淋巴瘤和胰腺癌的鑒別診斷及治療。方法 回顧性分析我院2000年1月至2008年4月期間經病理確診的5例胰腺淋巴瘤患者的臨床資料。結果 本組5例患者臨床癥狀以腹痛、發熱、黃疸為主，除1例外血漿CA19-9均正常，臨床表現無法區分胰腺淋巴瘤和胰腺癌，CT等影像學有助于鑒別診斷。胰腺淋巴瘤CT增強掃描后均見強化表現，胰管不粗，和周圍大血管關系緊密，鄰近血管結構被推移，但無浸潤、包繞現象。治療以化療為主，除1例失訪外，其余4例分別存活24、14、14、13個月。結論 胰腺淋巴瘤是一種罕見的疾病，臨床癥狀缺乏特異性，極易與胰腺癌混淆，治療和預后卻與胰腺癌不盡相同，臨床上應該盡量通過CT或超聲下穿刺明確診斷，以避免不必要的手術。
Objective To investigate the mRNA expressions of liver X receptor α (LXRα), farnesoid X receptor (FXR), steroid xenobiotic receptor (SXR) and liver receptor homolog 1 (LRH-1) gene in patients with cholesterol gallstone (CGS) disease in order to elucidate the biomolecular pathogenesis of gallstone formation. Methods Twenty-seven patients with CGS (CGS group) and 10 controls without gallstones (control group) were included in this study. Serum lipid composition (total cholesterol, triglyceride, high density lipoprotein cholesterol, apoprotein B, apoprotein A1), gallstone cholesterol concentration and biliary composition (cholesterol, bile salts, lecithin) were assayed. Biliary total lipid and cholesterol saturation index (CSI) were calculated. mRNA expressions of LRH-1, FXR, SXR and LXRα gene were determined by real-time polymorphism chain reaction. Results Serum high density lipoprotein cholesterol concentration was lower in CGS group than that in control group 〔(0.93±0.05) mmol/L vs (1.33±0.09) mmol/L, P＜0.001〕 and serum apoprotein A1 was also lower in CGS group than that in control group 〔(1.19±0.05) g/L vs (1.36±0.06) g/L, P＜0.05〕. There were no differences in serum total cholesterol, triglyceride and apoprotein B between two groups (Pgt;0.05). CSI was higher in CGS group than that in control group (1.17±0.02 vs 0.79±0.10), P＜0.001. Biliary cholesterol was also higher in CGS group than that in control group 〔(7.96±0.39) mol% vs (5.26±0.89) mol%, P＜0.01〕, while biliary total lipid was lower in CGS group than that in control group 〔(104.72±10.51) g/L vs (154.24±14.20) g/L, P＜0.05〕. There were no differences in bile salts and lecithin between two groups (Pgt;0.05). Expression of LRH-1 gene was higher in CGS group than that in control group (14.18±1.80 vs 7.22±2.22), the difference was statistically significant (P＜0.05). There were no differences in mRNA expressions of LXRα, FXR and SXR gene between two groups (Pgt;0.05). Conclusion CGS disease may be related to increased expression of LRH-1 gene.
目的 報道10例血清CA19-9明顯升高的膽管良性疾病病例。方法 回顧性分析2004年1月至2006年3月期間我院收治并經手術證實的10例血清CA19-9明顯升高（gt;500 U/ml）的膽管良性病變病例。結果 患者中男4例，女6例，年齡30~85歲，CA19-9為532.32~12 000.00 U/ml，除1例患者CA125輕度升高外，其他患者血清CEA、CA125及AFP均正常。膽總管結石8例，肝內膽管結石1例，原發性硬化性膽管炎1例； 除1例外均存在不同程度阻塞性黃疸。經治療后8例CA19-9水平在30 d內降至正常，另2例分別于術后2個月和3個月內降至正常。結論 CA19-9在膽管惡性腫瘤診斷方面的意義仍需進一步研究。