Objective To compare the clinical efficacy and safety of thrombolysis with anticoagulation therapy for patients with acute sub-massive pulmonary thromboembolism. Methods The clinical data of 84 patients with acute sub-massive pulmonary thromboembolism were analyzed retrospectively, mainly focusing on the in-hospital efficacy and safety of thrombolysis and/ or anticoagulation. The efficacy was evaluated based on 6 grades: cured, markedly improved, improved, not changed, deteriorated and died. Results Among the 84 patients,49 patients received thrombolysis and sequential anticoagulation therapy( thrombolysis group) , 35 patients received anticoagulation therapy alone( anticoagulation group) . As compared with the anticoagulation group, the thrombolysis group had higher effective rate( defined as patients who were cured, markedly improved or improved, 81. 6% versus 54. 3%, P = 0. 007) , lower critical event occurrence ( defined as clinical condition deteriorated or died, 2. 0% versus 14. 3% , P = 0. 032) . There was no significant difference in bleeding rates between the two groups ( thrombolysis group 20. 4% versus anticoagulation group 14. 3% , P gt; 0. 05) . No major bleeding or intracranial hemorrhage occurred in any of the patients. Conclusions Thrombolysis therapy may be more effective than anticoagulation therapy alone in patients with acute sub-massive pulmonary thromboembolism, and thus warrants further prospective randomized control study in large population.
目的 了解住院患者病死率以及死亡病例的年齡、性別及主要死因的分布狀況，為疾病預防治療提供科學依據。 方法 對重慶醫科大學附屬第二醫院2007年1月－2011年12月3 030例住院死亡患者進行統計分析，根據國際疾病分類第10版（ICD-10）進行疾病分類，所有資料經SPSS 13.0軟件進行統計分析。 結果 該院近5年共有出院患者173 411例，死亡3 030例，病死率1.75%。各年齡段男性患者病死率均高于女性。各年度、不同性別前3位死因均依次為：腫瘤、循環系統疾病、呼吸系統疾病。 結論 慢性非傳染性疾病是住院患者的主要死亡原因。提高醫療技術水平、普及群眾的預防保健知識、大力開展健康體檢是降低病死率的主要措施。