Chronic central serous chorioretinopathy (CSC) usually demonstrates frequent recurrence, diffuse leakage and persistent subretinal fluid, which cannot be absorbed, thus lead to photoreceptor damage and poor visual acuity. As glucocorticoids have been implicated in the pathogenesis of chronic CSC, various anti-glucocorticoids oral drugs were used in the clinic to promote retinal fluid absorption and reduce the central retinal thickness of the macula and improve the vision outcomes. In addition, the 5α-reductase-specific inhibitor finasteride, the P450-3A4 inducer rifampicin, circadian rhythmic regulator melatonin, and systemic anti-inflammatory drug methotrexate have also been put into clinical trials for chronic CSC, and achieved certain effects. However, most of the clinical studies on these oral drugs were case reports, but not multi-center randomized clinical trials. The long-term effects of these oral drugs need to be observed and studied further.
Diabetic foot is one of the most common complications of diabetes. The incidence of diabetic foot is high and its treatment is difficult. The cost of treating this disease is huge, which brings a huge burden to patients, families, and society. According to the development process of diabetic foot, this article reviews the rehabilitation nursing of diabetic foot from the perspective of rehabilitation nursing problems, intervention measures, and intervention modes. The rehabilitation nursing problems are summarized as body functions, body structures, activities, and participation; the intervention measures involve rehabilitation education, skin nursing, exercise therapy, mental nursing, hyperbaric oxygen therapy, platelet-rich plasma therapy, and rehabilitation aids; the intervention modes include preventive rehabilitation nursing, in-hospital rehabilitation nursing, community and family rehabilitation nursing, and palliative nursing.
This paper reviews the research progress on live-cell super-resolution fluorescence microscopy, discusses the current research status and hotspots in this field, and summarizes the technological application of super-resolution fluorescence microscopy for live-cell imaging. To date, this field has gained progress in numerous aspects. Specifically, the structured illumination microscopy, stimulated emission depletion microscopy, and the recently introduced minimal photon fluxes microscopy are the current research hotspots. According to the current progress in this field, future development trend is likely to be largely driven by artificial intelligence as well as advances in fluorescent probes and relevant labelling methods.