目的探討保留肝動脈血供的肝血流阻斷對肝切除術失血量和肝功能的影響。 方法回顧性分析了2007年9月至2012年12月期間上海交通大學醫學院附屬第三人民醫院118例行肝切除術患者的臨床資料，其中68例行保留肝動脈血供的肝血流阻斷（保留組），50例采用Pringl法行肝門阻斷（阻斷組），比較2組的手術失血量、接受輸血病例的比例、手術并發癥以及術后肝功能恢復情況。 結果全組無圍手術期死亡病例。保留組患者的平均手術時間、術中失血量、接受輸血患者的比例、術后腸道功能恢復時間以及術后并發癥發生率與阻斷組相比差異均無統計學意義（P＞0.05）；術后第1天及第5天，谷丙轉氨酶及谷草轉氨酶水平保留組明顯低于阻斷組（P＜0.05）。 結論保留肝動脈血供的肝血流阻斷法能有效控制肝斷面出血，明顯保護了肝臟功能，且并未延長手術時間。
ObjectiveTo explore the risk factors of intraabdominal complications (IACs), pancreatic fistula (PF), and operative death after pancreatoduodenectomy (PD), and to provide a theoretical basis in reducing the rates of them. MethodsClinical data of 78 patients who underwent standard PD surgery in The Third People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from Jun. 2003 to Nov. 2011 were collected to analyze the influence factors of IACs, PF, and operative death. ResultsThere were 29 cases suffered IACs (13 cases of PF included), and 6 case died during 1 month after operation. Univariate analysis results showed that IACs and PF occurred more often in patients with soft friable pancreas, diameter of main pancreatic duct less than 3 mm, preoperative biliary drainage, no pancreatic duct stenting, and without employment of somatostatin (P < 0.05), no influence factor was found to be related to operative death. Multivariate analysis results showed that patients with no pancreatic duct stenting (OR=1.867, P=0.000), soft texture of remnant stump (OR=1.356, P=0.046), and diameter of main pancreatic duct less than 3 mm (OR=2.874, P=0.015) suffered more IACs; PF was more frequent in patient with no pancreatic duct stenting (OR=1.672, P=0.030), soft texture of remnant stump (OR=1.946, P=0.042), and diameter of main pancreatic duct less than 3 mm (OR=1.782, P=0.002);no independent factor was found to have relationship with operative death. ConclusionsSoft texture of remnant stump, diameter of main pancreatic duct less than 3 mm, and no pancreatic duct stenting are independent risk factors that should be considered in indications for PD surgery.