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  • west china medical publishers
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    find Author "朱德明" 4 results
    • Clinical Application of High Flow Rate Modified Ultrafiltration

      Objective To compare the clinical effect between high flow rate modified ultrafiltration (HMUF) and conventional modified ultrafiltration(CMUF), and the effect on hemodynamic data and inflammatory mediators. Methods Forty children were divided into two groups with random number table, HMUF group and CMUF group, 20 cases each group. Hematocrit (HCT) and hemodynamic changes were recorded and the concentration of tumor necrosis factor (TNF) and interleukin 6 (IL-6) were measured. Results The operations were done uneventfully with moderate hypothermia cardiopulmonary bypass in 40 patients. Duration of ultrafiltration of HMUF group (7.83±0. 75 min) was less than that of CMUF group (13.86±1.95 min, P〈0.01). The volumes ultrafiltrated of HMUF group (440.00±91.86ml) was more than that of CMUF group (372.22±56.52ml, P〈0.01). There are no significant differences about the hemodynamic data, HCT, TNF and IL-6 between two groups. Conclusion The HMUF is safe and efficient,when it was used after pediatric cardiopulmonary bypass, the duration of ultrafiltration can be shortened significantly.

      Release date:2016-08-30 06:26 Export PDF Favorites Scan
    • 離心泵在兒童體外循環中的應用

      目的總結離心泵在兒童先天性心臟病體外循環手術中的應用經驗。方法40例患者(年齡5.55±4.36歲、體重17.91±11.95kg)中,首次手術29例,二次手術11例。在體外循環中均使用Jostra離心泵,轉流過程中隨時調整轉速,保證在不同阻力下有相對恒定的灌注流量。結果淺低溫平行循環2例,深低溫停循環(DHCA)4例,深低溫低流量(DHLF)3例,DHCA+DHLF 1例,中低溫中高流量30例。總轉流時間136.48±87.27min(23~478min),主動脈阻斷時間71.61±36.15min(13~153min),DHcA時間12~67min,DHLF時間4~52min。結論離心泵操作簡便,預充量小,對血液成分的破壞相對較少,在危重患者中值得推廣使用,適合作長時間心室輔助循環使用。

      Release date:2016-08-30 06:23 Export PDF Favorites Scan
    • 平衡超濾法與改良超濾法的應用比較

      目的 比較平衡超濾法和改良超濾法在小兒心肺轉流術(CPB)中使用的效果. 方法 40例先天性心臟病患者,隨機分成兩組:平衡超濾組(BUF組)和改良超濾組(MUF組),分別在整個CPB期間和停CPB后進行超濾.結果 BUF組在CPB中濾出液體815.0±300.9ml,MUF組濾出液體394.4±81.4ml;BUF組在CPB過程中炎癥因子的濃度無明顯變化,而MUF組則有上升趨勢,CPB結束時BUF組炎癥因子濃度明顯低于MUF組(P<0.05);MUF組進行超濾時,紅細胞壓積明顯提高,炎癥因子濃度有所上升. 結論 平衡超濾法能在CPB中維持較低的體內炎癥介質濃度,改良超濾法可以在術后迅速濃縮血液,但對降低炎癥介質的濃度影響較小.

      Release date:2016-08-30 06:31 Export PDF Favorites Scan
    • 心臟手術深低溫低流量灌注不同血氣管理對嬰幼兒腦保護的影響

      摘要 目的 在深低溫低流量灌注模式下,觀察快速降溫期應用不同穩態血氣管理對嬰幼兒腦功能的影響。方法 將20例法洛四聯癥患者隨機分為pH穩態和alpha穩態兩組,并根據不同時間點、低流量和血氣管理方案隨機平均分層行析因分析。腦功能監測為:生化指標、腦溫、腦電圖、智商等。結果 應用pH穩態的腦部溫差較應用 alpha穩態低;復溫末alpha穩態組中低流量25ml/kgmin-1乳酸含量最高;術后24小時alpha穩態組中低流量25ml/kgmin-1神經元特異性烯醇酶含量最高;術后 4天腦電圖和術后 2個月智商兩種穩態組間差別無顯著性意義。結論 深低溫低流量灌注快速降溫期應用pH穩態進行血氣管理可起到更好的腦保護作用。

      Release date:2016-08-30 06:33 Export PDF Favorites Scan
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