bjective To study the change of mucins of expression in lithic cholecystitis and cholecystic adenomatiod polyps. MethodsMUC1 and MUC3 were detected in the mucosa of human normal gallbladders (20 cases, control group), of calcareous cholecystitis (38 cases, calcareous group) and of adenomatoid polyps (18 cases, polyp group) with immunohistochemical stains and Western blotting methods. ResultsThe positive rate and optical density values of MUC1 were increased significantly in calcareous and polyp group vs control group (P＜0.01), otherwise, MUC3 was decreased markedly (P＜0.01). Conclusion The expressions of MUC1, MUC3 were not synchronization in different lesions of cholecyst.
目的 提高對幼年性息肉致小腸套疊的診治水平。方法 按檢索策略，檢索PubMed、中國生物醫學文獻數據庫（CBM）、中文科技期刊全文數據庫（CSJD）、中國期刊全文數據庫（CJFD）及CNKI數字圖書館的相關文獻，并結合筆者所在醫院于2011年收治的1例幼年性息肉致小腸套疊病例資料，對該病進行一系統的描述。結果 共檢出相關文獻65篇，按納入及排除標準，最后納入6篇文獻。共7例患者，臨床表現為腹痛、嘔吐5例，便血2例，貧血3例；經超聲檢查診斷4例；全組均行小腸切除腸吻合術，其中1例為腹腔鏡輔助手術；有1例患者共實施了3次手術，最后死于惡液質，其余患者恢復較好。結論 幼年性息肉致小腸套疊為臨床罕見疾病，超聲檢查仍為首選診斷方法；提高醫師對該病的認識，術中徹底探查腸道，必要時術中行快速冰凍切片病理學檢查，有望減少息肉遺留，改善患者的預后。
Polypoidal choroidal vasculopathy (PCV) is originally defined as a separate disease, but with the development of imaging techniques, it has now been included in the spectrum of neovascularization. In the Asian population, the prevalence of PCV is high, and with the deepening of clinical studies, the pathological characteristics, pathogenesis and clinical manifestations of PCV have been more deeply understood. Through dynamic observation and histopathological study of PCV lesions during operation, it can be confirmed that the lesions are mainly located between the retinal pigment epithelium and the Bruch membrane, rather than originating from the choroidal circulation, which is of great significance for understanding the origin and natural course of PCV. It is worth noting that although a theoretical bridge has been established between age-related macular degeneration (AMD)/PCV, there is a lack of intuitive clinical data on the ultrastructural and molecular manifestations of the cells/stroma in the local lesions of the eye, especially the progression of AMD/PCV from early/middle stage to exudative stage. It is precisely because of this that highly attractive research topics and exploration space are proposed for the future.
Objective To systematically evaluate the diagnostic value of artificial intelligence assisted narrow-band imaging endoscopy diagnostic system for colorectal adenomatous polyps. Methods Pubmed, Embase, Web of Science, Cochrane Library, SinoMed, China National Knowledge Infrastructure, Chongqing VIP and Wanfang databases were searched. The diagnostic trials of the artificial intelligence assisted narrow-band imaging endoscopy diagnostic system for colorectal adenomatous polyps were comprehensively searched. The search time limit was from January 1, 2000 to October 31, 2022. The included studies were evaluated according to the Quality Assessment of Diagnostic Accuracy Studies-2, and the data were meta-analysed with RevMan 5.3, Meta-Disc 1.4 and Stata 13.0 statistical softwares. Results Finally, 11 articles were included, including 2178 patients. Meta-analysis results of the artificial intelligence assisted narrow-band imaging endoscopy diagnostic system for colorectal adenomatous polyps showed that the pooled sensitivity was 0.91, the pooled specificity was 0.88, the pooled positive likelihood ratio was 7.41, the pooled negative likelihood ratio was 0.10, the pooled diagnostic odds ratio was 76.45, and the area under the summary receiver operating characteristic curve was 0.957. Among them, 5 articles reported the diagnosis of small adenomatous polyps (diameter <5 mm) by the artificial intelligence assisted narrow-band imaging endoscopy diagnostic system. The results showed that the pooled sensitivity and the pooled specificity were 0.93 and 0.91, respectively, and the area under the summary receiver operating characteristic curve was 0.971. Five articles reported the accuracy of endoscopic diagnosis for adenomatous polyps of those with insufficient experience. The results showed that the pooled sensitivity and the pooled specificity were 0.84 and 0.76, respectively. The area under the summary receiver operating characteristic curve was 0.848. Compared with the artificial intelligence assisted narrow-band imaging endoscopy diagnostic system, the difference was statistically significant (Z=1.979, P=0.048). Conclusion The artificial intelligence assisted narrow-band imaging endoscopy diagnostic system has a high diagnostic accuracy, which can significantly improve the diagnostic accuracy for colorectal adenomatous polyps of those with insufficient endoscopic experience, and can effectively compensate for the adverse impact of their lack of endoscopic experience.
【摘要】 目的 探討經陰道彩色多普勒超聲診斷子宮內膜息肉的價值，進一步提高子宮內膜息肉的診斷準確率。 方法 2009年1月-2010年12月，對48例子宮內膜息肉患者，經陰道彩色多普勒超聲發現病灶后觀察其位置、大小、內部回聲及病灶內部和周邊的彩色血流情況，并與手術病理結果對照。 結果 經陰道彩色多普勒超聲診斷子宮內膜息肉的準確率為87.5%， 2例誤診為子宮黏膜下肌瘤，3例誤診為子宮內膜增厚，1例漏診。 結論 經陰道彩色多普勒超聲對子宮內膜息肉有較高的臨床診斷價值。【Abstract】 Objective To investigate the value of transvaginal color doppler ultrasonography in the diagnosis of endometrial polyps and to further improve the diagnostic accuracy. Methods From January 2009 to December 2010, fourty-eight patients with endometrial polyps participated in this study. Transvaginal color doppler ultrasonography was used to observe the location, size, and internal echo of the lesions, and the color flow within and around the lesions. Then, we compared all the ultrasonic features with pathological findings. Results The diagnostic accuracy of transvaginal color doppler ultrasonography in the diagnosis of endometrial polyps was 87.5%. Two cases were misdiagnosed as submucosal uterine fibroids, 3 as endometrial thickening, and 1 missed. Conclusion Transvaginal color doppler ultrasonography has a high clinical value in the diagnosis of endometrial polyps.
目的 分析Peutz-Jeghers綜合征臨床特點，以提高診治水平。 方法 2008年11月-2010年1月對8例Peutz-Jeghers綜合征的臨床資料進行回顧性分析。 結果 男女各4例，年齡13～41歲，病程20 d～40年。8例均有黑斑和息肉，5例有明確的家族史。首發表現以腹痛為主，輕度抑郁表現2例，并發腸套疊2例，結腸癌1例。病理報告：錯構瘤4例。外科手術治療1例，結腸鏡治療6例，保守治療1例。 結論 Peutz-Jeghers綜合征易并發抑郁癥、腸套疊和惡性腫瘤，患者需心理治療和遺傳咨詢，腸鏡下息肉切除是主要手段。