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腹腔鏡下治療十二指腸重復畸形1例報道

交界可切除胰頭癌新輔助化療后行聯合靜脈切除重建 LPD 的初步體會

目的探討交界可切除胰頭癌新輔助化療后行聯合靜脈切除重建的腹腔鏡胰十二指腸切除術（laparoscopic pancreaticoduodenectomy，LPD）的安全性及可行性。方法回顧性收集并分析 2019 年 8 月至 2021 年 1 月期間于四川大學華西醫院上錦分院肝膽胰微創外科實施的 4 例交界可切除胰頭癌新輔助化療后行聯合血管切除重建的 LPD 患者的臨床資料。結果4 例患者均在完全腹腔鏡下完成手術，手術時間分別為 520、452、375 和 430 min，術中出血量分別為 300、800、150 和 200 mL，術后住院時間分別為 36、20、16 和 16 d。術后 1 例患者出現膽汁漏、行再次引流后好轉出院，1 例出現乳糜漏，導致引流管拔除時間及住院時間延長，其余 2 例未出現并發癥，正常出院。4 例患者術后病理學檢查證實均為胰頭導管腺癌，總生存期分別為 18、12、20 和 11 個月（仍存活）。結論對于高度選擇性的交界可切除胰頭癌新輔助化療后行聯合靜脈切除重建的 LPD 在經驗豐富的大的胰腺中心是安全可行的，但仍需大樣本隨機對照試驗來驗證這一結論。

Totally Laparoscopic Associating Liver Tourniquet and Portal Ligation for Staged Hepatectomy Using The Anterior Approach Techniquefor Hepatocellular Carcinoma with Hepatitis B Cirrhosis

ObjectiveTo investigate the application value of totally laparoscopic associating liver tourniquet and portal ligation for staged hepatectomy (ALTPS) using the anterior approach technique for hepatocellular carcinoma (HCC) with hepatitis B cirrhosis. MethodsIn September, 2014, a patient suffered cirrhotic hepatocellular carcinoma in the right liver scheduled for two-stage liver resection, in whom the future liver remnant (FLR) was considered too small (FLR/standard liver volume:29.1%, FLR/body wight:0.49%). In the first stage, using totally laparoscopic technique, a tourniquet was placed around the parenchymal transection line on the Cantlie's line via an anterior approach through retrohepatic tunnel for staged right hepatectomy, and the right portal vein was ligated. In the second stage, totally laparoscopic right hemihepatectomy was carried out on 10 days after the first-stage operation that achieved sufficient hypertrophy of the FLR. ResultsThe FLR on postoperative day 4 of the first stage increased from 301.48 to 496.45 mL (FLR/standard liver volume:47.9%, FLR/body wight:0.81%), with a 64.67% hypertrophy. And the FLR on postoperative day 8 of the first stage increased to 510.96 mL (FLR/standard liver volume:49.3%, FLR/body wight:0.84%), with a 69.48% hypertrophy. The remnant liver volume on postoperative day 5 of the second stage increased to 704.53 mL. The duration of the first stage was 180 min, intraoperative blood loss was 50 mL, and patient did not received a blood transfusion. The duration of the second stage was 220 min, intraoperative blood loss was 400 mL, and patient did not required a blood transfusion. No serious complications happened. The patient was discharged on 7 days after the second stage. ConclusionsAs a effective, safe, simple, and "non-touch" technique which provided a less aggressive modification of the ALPPS procedureto achieve oncological efficacy, the totally laparoscopic ALTPS using the anterior approach technique also could achieve sufficient hypertrophy of the FLR in several days. A proper expansion of the indications for the procedure is safe and feasible in HCC patients with cirrhosis.