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Analysis of Failure of Perventricular Device Closure of Ventricular Septal Defect

摘要:目的:分析微創外科室間隔缺損(ventricular septal defect,VSD)封堵失敗原因,以期提高術前超聲心動圖篩查水平。方法:回顧性分析25例微創外科VSD封堵失敗改行修補術病例,對比超聲表現及手術所見,歸納總結產生并發癥的原因。結果:殘余分流與VSD假性膜部瘤右室面具有多個出口和低估VSD大小密切相關;VSD合并主動脈瓣右冠瓣脫垂是主動脈瓣反流的主要原因;封堵器移位與低估VSD大小且使用偏心封堵器有關;原有三尖瓣反流加重和發生Ⅲ度房室傳導阻滯VSD均位于隔瓣下方;封堵失敗組較封堵成功組缺損偏大,差異具有統計學意義(Plt;0.05)。結論:超聲心動圖對VSD及其毗鄰結構的細致評估,有助于嚴格適應證,提高手術成功率。 Abstract: Objective:To analyze the failure of perventricular closure of ventricular septal defect (VSD), in order to improve the preoperative echocardiography examination. Methods: Twentyfive cases underwent surgical repair after failure of perventricular closure of VSD were included in this study. With combination of echocardiographic and surgical findings, retrospective analysis of the failure of perventricular closure of VSD were attempted to summarize the cause of complications.Results: Residual ventricular communication was due to underestimation of size of VSD and pseudomembranous aneurysm resulting in multiple outlets of VSD on the right ventricle side; preoperative prolapse of rightcoronary cusp was the main reason for mild or greater than mild aortic valve regurgitation after eccentric device closure of VSD; Underestimation of the size of VSD and using eccentric occluder device were responsible for the displacement of VSD occluder device. Postoperative aggravated tricuspid regurgitation and Ⅲ°atrialventricular block (AVB) were attributed to VSDs located under the septal leaflet of tricuspid valve. The size of VSD in group of failed perventricular device closure of VSD was larger than that in group of successful device closure of VSD,and the difference was significant(Plt;0.05). Conclusion: Echocardiography vividly reveals VSD and adjacent structures, which should be used in accessing the anomaly and defect and formulating surgical plans to reduce surgical morbidity and mortality.

先天性心臟病介入治療48例

目的 總結對先天性心臟病患者行介入治療的臨床經驗，以提高介入治療的成功率。 方法 48例先天性心臟病患者采用Cardiacure-TM封堵器行介入治療，其中房間隔缺損（ASD）21例，動脈導管未閉（PDA）12例，室間隔缺損（VSD）12例，ASD合并PDA 1例，VSD合并PDA 2例。 結果 全組患者無死亡，一次性封堵成功44例，介入封堵治療成功率為91.7％（44/48）;15例次 PDA患者介入封堵治療成功率為100％（15/15）; 22例次ASD患者成功率為90.9%（20/22）, 14例次VSD患者成功率為85.7％（12/14）。 封堵傘于術中脫落3例，其中ASD傘脫落2例，VSD傘脫落1例；介入治療未成功1例。4例封堵未成功的患者中3例擇期行體外循環修補手術治愈，1例行急診體外循環修補手術治愈。隨訪40例，隨訪時間1~19個月，復查心臟雜音消失，心臟彩色超聲心動圖提示無殘余分流。 結論 介入治療是治療先天性心臟病的有效方法，心胸外科醫師掌握該項技術有其較多的優勢。

Transcatheter closure of congenital heart disease under the guidance of transthoracic echocardiography

Objective To explore the feasibility of transcatheter closure of congenital heart disease (CHD) under the guidance of transthoracic echocardiography (TTE). Methods A total of 37 patients with CHD who received transcatheter closure under the guidance of transthoracic echocardiography from November 2013 through November 2015 in our hospital were recruited. There were 15 males and 22 females, aged 1 to 16 years. Among them 32 patients suffered atrial septal defect and 5 patients had patent ductus arteriosus. The transcatheter closure of CHD was performed under the guidance of TTE. The patients underwent echocardiography follow-up at one, three and six months after surgery. Results Closure devices were successfully implanted in 37 patients under TTE guidance. The procedure was simple and safe. During the follow-up, no severe complication such as valvular injury, pericardial effusion, residual shunt and peripheral vascular injury occurred. Conclusion Transcatheter closure of CHD under TTE guidance is a feasible method and worth further clinical application.

Percutaneous occlusion of major aortopulmonary collaterals in children after cardiac surgery

Objective Tho evaluate the outcomes of early percutaneous occlusion of these residual major aortopulmonary collateral arteries after heart surgery. Methods This was a retrospective review of children undergoing early percutaneous embolization of major aortopulmonary collateral arteries after cardiac surgery. From January 2013 to February 2017, 52 consecutive patients with postoperative residual major aortopulmonary collateral arteries were treated with percutaneous embolization (38 males, 14 females; median age of 10.0 months, interquartile range 14.0 months; median weight 8.6 kg, interquartile range 4.4 kg). Fifty-one patients were cyanotic and 1 patient was acyanotic. Forty-nine patients underwent corrective surgery and 3 patients underwent B-T shunt. Results Typical symptoms and signs of major aortopulmonary collateral arteries included: elevated left atrial pressure; focal lung infiltration, pink or blood-stained frothy sputum. The median time interval from cardiac surgery to percutaneous occlusion of major aortopulmonary collateral arteries was 5 (9) d, median duration of mechanic ventilation support since occlusion was 72 (159) h, mechanic ventilation support was 239 (480) h and median duration of intensive care unit was 19 (29) d. There was no death in this group. Conclusion Angiocardiography could be able to demonstrate the existence of postoperative major aortopulmonary collateral arteries. The early percutaneous occlusion appears to be simple, safe and effective.

經胸微創膜部室間隔缺損封堵術圍術期炎癥因子的變化

Safety and Efficacy of Perventricular Device Closure of Subarterial Ventricular Septal Defect

ObjectiveTo assess the safety and efficacy of a new surgical strategy, perventricular device closure, for the treatment of subarterial ventricular septal defect (VSD). MethodsThirty-nine patients younger than 10 years with subarterial VSD who received surgical repair in West China Hospital from November 2010 to May 2012 were included in this study. There were 18 male and 21 female patients with their age of 5.9±3.2 years. Perventricular device closure was performed with eccentric device under the guidance of transesophageal echocardiography (TEE). Residual shunt, valvular regurgitation (including aortic regurgitation)and arrhythmias during perioperative period and follow-up were analyzed. ResultsThirty-three patients successfully received perventricular device closure, and 6 patients received conversion to open surgical repair. Postoperative ICU stay was 2.2±0.8 days, and length of hospital stay was 4.8±1.8 days. Major postoperative complications included residual shunt and mild or less aortic regurgitation. Mean follow-up duration was 7±2 months. No obvious arrhythmia, moderate or severe valvular regurgitation was observed during follow-up. ConclusionPerventricular device closure is safe, efficacious and minimally invasive for the treatment of subarterial VSD in pediatric patients with suitable anatomic characteristics with good mid-term results.

Amplatzer Transcatheter and Surgical Closure for Ostium Secundum Atrial Septal Defects: A Systematic Review

Objective　To determine the efficacy and safety of Amplatzer transcatheter closure and surgical closure for ostium secundum atrial septal defects. Methods　MEDLINE (1966-July 2006), EMBASE (1966-July 2006), The Cochrane Library (Issue 2, 2006) and CBMdisc (1979-July 2006) were searched for randomized controlled trials or non-randomized controlled trials. Data were extracted by two reviewers using a specially designed extraction form. The quality of included trials was critically assessed. The Cochrane Collaboration’s RevMan 4.2 software was used for data analysis. Results　Sixteen non-RCTs involving 2 043 patients were included. No deaths were reported in 14 trials. The other two trials reported one death respectively in the surgical group. Meta-analysis of 12 trials involving 1 722 patients showed that the procedure success rate for the Amplatzer group was lower than that for the surgical group [WMD:0.95, 95%CI (0.92,0.98)]. Similar results were also found in the complete closure rate in 24-hour follow-up [6 trials involving 1 106 patients, WMD:0.96, 95%CI (0.92 to 1.00)], the complication rate [16 trials involving 1 971 patients, WMD:0.27, 95%CI(0.21 to 0.35)] and the transfusion rate [14 trials involving 1 807 patients, WMD:0.03, 95%CI(0.02 to 0.06)]. Conclusions　The success rate for Amplatzer device closure of ASD is lower than that of surgical repair. However, the complication rate, length of hospital stay and transfusion rate are lower or shorter for Amplatzer device closure than for surgical repair. Based on appropriate patient selection, Amplatzer closure of ASD is a safe and effective alternative to surgical repair.

Feasibility of Blocking Congenital Ventricular Septal Defect or Congenital Atrial Septal Defect through Right Subaxillary Incision

ObjectiveTo evaluate the feasibility and safety of blocking congenital ventricular septal defect or congenital atrial septal defect through the small vertical incision of right subaxillary. MethodsWe retrospectively analyzed the clinical data of 38 patients underwent the surgery of blocking congenital ventricular septal defect or congenital atrial septal defect in our hospital from January to August 2015. There were 22 males and 16 females with a mean age of 10.3±5.2 months, weight of 8.2±3.5 kg. ResultsThere were 34 patients (89.5%) successfully blocked through the small vertical cut of right subaxillary. The average blood loss of those 34 patients was 19.5±13.4 ml and the mean time of surgery was 58.4±28.5 minutes. Four patients (10.5%) with ventricular septal defect failed to block because of aortic valve prolapse. Those patients underwent direct repair of ventricular septal defect under extracorporeal circulation while general anesthesia. There was no serious adverse event during the surgery. The extubation time was 3.9±1.6 hours, the ICU monitoring time was 1.8±0.8 days and the hospital stay time was 3.2±0.5 days. All patients discharged uneventfully. ConclusionBlocking congenital ventricular septal defect or congenital atrial septal defect through the cut of right subaxillary is a feasible, effective, safe, and minimally invasive method. The effect of early follow-up is well.

Application of adjustable curved sheath in transcatheter closure of atrial septal defect with internal jugular vein solely guided by transthoracic echocardiography: A case report

A case of a 4-month-old child with an aortopulmonary fenestration weighing 6.6 kg who underwent successful transthoracic minimally invasive occlusion in our hospital was reported in this article. The child was transferred from the intensive care unit (ICU) to the general ward 1 day after surgery and discharged 5 days later. Compared with conventional ligation or repair of extracorporeal circulation for the aortopulmonary fenestration, the transthoracic minimally invasive occlusion is characterized by less trauma and faster recovery. However, it requires strict surgical indications and is not suitable for all patients with aortopulmonary fenestration.

Perventricular Closure of Atrial Septal Defect and Ventricular Septal Defect Through a Single Port: The Initial Experience

目的評價單穿刺點經胸微創封堵治療房間隔缺損（ASD）合并室間隔缺損（VSD）的安全性及有效性。 方法納入2014年6月至2015年8月于我院成功完成單穿刺點經胸微創封堵術治療ASD合并VSD的8例患兒，分析患兒在術后第l個月、3個月、6個月的門診隨訪資料。觀察圍術期及隨訪期間患者殘余分流、瓣膜反流、心律失常等并發癥發生情況。 結果8例患兒中，術后早期均無殘余分流、心律失常，微量三尖瓣反流（TR）患者1例（12.5%）。平均隨訪時間5～9（6±2）個月，各瓣膜均未發現中度及以上反流，未發現存在血栓、嚴重心律失常、死亡的患者。 結論單穿刺點經胸微創封堵治療ASD合并VSD安全、有效，且更為微創。