目的:評價益生菌在預防和治療兒童喘息性疾病中的效果。方法:將393例喘息性疾病患兒分為觀察組206例,對照組187例,對照組187例常規治療,觀察組206例在對照組187例常規治療的基礎上給予口服雙歧桿菌三聯活菌腸溶膠囊。結果:觀察組治愈時間明顯少于對照組,兩組比較差異有顯著性(Plt;005),觀察組總復發率為342%,對照組總復發率為433%,兩組比較差異有顯著性(Plt;005)。結論:添加益生菌對預防和治療兒童喘息性疾有積極的效果。
Objective To investigate the correlation between persistent wheezing and positive result of sputum fungal culture in patients with chronic obstructive pulmonary disease ( COPD) . Methods The COPD patients who hospitalized in the respiratory department of Shanghai First People’s Hospital, Zhongshan Hospital and Huadong Hospital fromJanuary 2005 to December 2007 were analyzed retrospectively. Results Thirty-five cases were enrolled in the persistent wheezing group and 43 cases in the non-wheezing group. In the wheezing group, sputumfungal culture revealed positive yield in 32 cases while Aspergillus were isolated in 12 cases. In the non-wheezing group, sputum fungal culture revealed only 11 cases positive, and none of which were Aspergillus positive. Aspergillus distributions in the two groups were significantly different( P lt;0. 05) . There was also significant difference in the positive result of sputum fungal culture ( 91. 4% vs 25. 6%, P lt;0. 01) , while there was no significant difference in positive result of bacterial culture( 28. 6% vs 39. 5%, P gt; 0. 05) . In the wheezing group, the patients with antifungal treatment showed better prognosis than those without antifungal treatment( 81. 0% vs 36. 4% , P lt;0. 05) . Conclusion The persistent wheezing in the patients with COPD is correlated with the fungi, especially Aspergillus airway colonization.