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Fahr病1例并文獻復習

Influence of Bromocriptin on Cardiac Valve in Patients with Pituitary Prolactinoma

ObjectiveTo investigate the risk of cardiac valve regurgitation in patients with pituitary prolactinoma treated with bromocriptine for a long time. MethodsBetween January 2012 and February 2013, 26 pituitary prolactinoma patients treated with bromocriptine for at least 6 months were included in the observation group, and 101 healthy people were regarded as the control group. Transthoracic echocardiography were performed on these patients for cardiac regurgitation, and the echocardiographic data were compared between the two groups. ResultsTrace tricuspid regurgitation was presented in 38.46% of patients in the observation group, and 19.80% of the controls (P=0.046). Interventricular septum thickness was (8.62±0.31) mm in patients in the observation group, and it was (8.57±0.12) mm in the controls (P=0.042). ConclusionNo clinical significant cardiac valve regurgitation has been observed in pituitary prolactinoma patients treated by bromocriptin for a long time. Long-term echocardiographic follow-up of these patients is necessary.

經鼻蝶鞍區病變切除術后鞍底重建及圍手術期處理

目的 總結經鼻蝶鞍區病變切除術后鞍底重建及圍手術期處理的相關經驗。 方法 回顧性分析2007 年10 月－ 2008 年12 月收治的132 例經單鼻孔蝶竇入路行鞍區病變切除術患者鞍底重建及圍手術期處理方法。男64 例，女68 例；年齡19 ～ 74 歲，平均45.7 歲。病因：垂體無功能腺瘤91 例，生長激素腺瘤22 例，泌乳素腺瘤9 例，促腎上腺素皮質激素腺瘤2 例，促甲狀腺素釋放激素腺瘤1 例，Rathke 囊腫5 例，鞍內型顱咽管瘤2 例。術中采用由人工硬膜、顱骨和蝶竇黏膜組成的夾心層法重建鞍底。 結果 術后4 例發生少量腦脊液漏，給予腰大池持續引流1 周后治愈。術后再出血2 例，經藥物治療消退；術后高熱、感染3 例，經抗生素治療后2 例好轉，1 例配合腰穿持續引流后治愈。患者均獲隨訪，隨訪時間28 ～ 42 個月，平均35.2 個月。患者術前癥狀及體征術后不同程度好轉。 結論 以人工硬膜加自體骨片等材料為主體的鞍底重建技術具有解剖還原、操作簡便、穩固可靠、創傷小、無排斥等特點，輔以周全的圍手術期護理，能夠取得良好的重建效果。

Association between Interleukin-1α Polymorphisms and Risk of Intracranial Aaneurysm

目的　探討白細胞介素1α（IL-1α）基因多態性與顱內動脈瘤發生的關系。 方法　以2010年6月－2012年3月145例顱內動脈瘤患者和181例正常對照者為研究對象，采用聚合酶鏈反應-限制性片段長度多態性檢測IL-1α-889C/T和+4845G/T多態性，統計分析基因多態性與顱內動脈瘤的相關性。 結果　IL-1α-889C/T位點：CT/TT基因型在顱內動脈瘤組中的頻率為32.4%，顯著高于其在對照組中的頻率（21.5%），兩組相比差異有統計學意義（χ2=4.90，P＜0.05）；T等位基因在顱內動脈瘤組中的頻率為16.9%，顯著高于其在對照組中的頻率（10.8%），兩組相比差異有統計學意義（χ2=5.17，P＜0.05）。IL-1α+4845G/T多態性在兩組人群中的分布差異無統計學意義（P＞0.05）。 結論　IL-1α -889C/T多態性與顱內動脈瘤的發病有關，-889T等位基因可能是顱內動脈瘤的遺傳易感基因。

Clinical Observation and Quality of Life in Patients with Pituitary Adenoma Treated by Microneurosurgery

【摘要】 目的 分析手術治療垂體瘤患者長期臨床恢復以及生活質量改善情況。 方法 回顧性分析2007年12月-2008年9月手術治療的103例垂體瘤患者術前以及術后長期隨訪資料，使用SF-36量表對術前、術后患者生活質量進行評估，分析手術治療前后患者癥狀、激素水平恢復情況以及生活質量改善情況，并進一步分析腫瘤大小、侵襲程度對術后生活質量的影響。 結果 術后頭痛癥狀消失52例，視力改善76例，其他癥狀具有不同程度改善；術后SF-36生活質量評估結果顯示，患者除精神健康外的7個維度（生理機能、生理職能、軀體疼痛、一般健康狀況、精力、社會功能、情感職能）均有明顯改善（P＜0.05），不同腫瘤大小及侵襲程度的患者術后生活質量評分均無統計學意義（P＞0.05），垂體功能完全恢復者生活質量評分高于垂體功能低下者（P＜0.05）。 結論 顯微手術治療垂體瘤患者可明顯改善患者的一般癥狀、提高患者的生活質量，單純腫瘤的大小和侵襲程度對術后生活質量的影響程度較小，術后垂體功能的恢復程度明顯影響患者的生活質量，垂體瘤術后患者的激素長期替代治療尚需進一步加強。【Abstract】 Objective To analyze the long-term clinical recovery and quality of life (QoL) in patients with pituitary adenoma treated by microneurosurgery. Methods The clinical data of 103 patients undergoing microneurosurgery from December 2007 to September 2008 were retrospectively analyzed, health-related questionnairs (SF-36) were used to assess the QoL. The post-surgery recovery of symptoms, endocrine function, and QoL were compared with those of pre-surgery, then the correlation between tumor size, invasive behavior, and QoL were analyzed. Results Headache disappeared in 52 patients. Visual symptoms improved in 76 patients. Other symptoms were also improved. Seven concepts (physical functioning, role physical, bodily pain, general health, vitality, social functioning, role emotioning) were improved after surgery (Plt;0.05). The eight health concepts of SF-36 showed no significant difference between patients with different tumor size and invasive behavior (Pgt;0.05). Differences were considered statistically significant between normal and abnormal pituitary function groups after surgery(Plt;0.05) in all concepts. Conclusion Microneurosurgical treatment can improve the general symptoms and the QoL. The tumor size and invasion have little influence on the QoL after surgery, but the improvement of hormone deficiency has influence on the QoL significantly. More attention should be given to the long-term hormone replacement therapy after the pituitary adenoma surgery.

庫欣綜合征伴足潰瘍兩例

The application of clinical multi-disciplinary team in the diagnosis and treatment of pituitary adenoma and related diseases

Multi-disciplinary team (MDT) is increasingly applied in oncology and refractory diseases. In recent years, MDT has also been applied in diagnosis and treatment of pituitary adenoma and related diseases. This review summarizes the advantages and characteristics of the MDT diagnosis and treatment mode, and analyzes the application and effect of the MDT diagnosis and treatment mode in the Center of Pituitary Adenoma and Related Diseases, West China Hospital, Sichuan University. So far, it has shown that MDT has advantages such as it is professional, full of collaborative interaction, and efficient and optimized. It is a platform of multi-disciplinary cooperation and resources in the diagnosis and treatment of difficult diseases. Case discussion in MDT mode is conducive to timely selection of the best treatment options for patients with pituitary adenoma and related diseases, providing a good learning platform for doctors with different professional backgrounds, and promoting the improvement of professional diagnosis and treatment level of doctors in related departments. The development of MDT will help us to use limited medical resources efficiently, promote the medical team to be more specialized, optimize the diagnosis and treatment process, and improve the effectiveness of the treatment, for benefiting more patients with pituitary adenomas and related diseases.