As a member of the nuclear receptor superfamily, retinoic acid receptor-related orphan receptor α (RORα) is involved in a variety of pathophysiological processes by regulating the expression of related genes. RORα plays an important role in biological rhythm, metabolism, vascular hyperplasia and inflammation, which are closely related to the occurrence and development of tumors. This review focuses on the biological characteristics of RORα and its role and mechanism in tumorigenesis and development, so as to provide new ideas for tumor-related research.
目的 檢測系統性紅斑狼瘡（SLE）患者CD4+CD25+調節性T細胞（Treg）上Ⅰ型干擾素受體（IFNAR）的分布格局，了解Ⅰ型干擾素對SLE患者CD4+CD25+Treg產生直接影響的作用靶點。 方法 選取2010年9月－2011年10月間20例初次確診的SLE患者（SLE組）和20例健康女性（對照組），分離SLE患者和對照組的外周血單個核細胞，采用流式細胞術測定CD4+CD25+Treg上IFNAR的表達。 結果 ① IFNAR1、IFNAR2在Treg和CD4+CD25? T細胞表面均有表達；兩組Treg表面IFNAR1和IFNAR2的表達水平均高于CD4+CD25? T細胞。② 與對照組相比，SLE組Treg表面IFNAR1表達的平均熒光強度明顯增高（P=0.001）。③ SLE組Treg表面IFNAR1表達平均熒光強度與疾病活動指數評分呈正相關（rs=0.505，P=0.023）。 結論 SLE患者CD4+CD25+Treg表面相對高表達IFNAR1且與疾病活動性相關，提示Ⅰ型干擾素以Treg上IFNAR為靶點在SLE發病機制中可能發揮重要作用，為SLE等自身免疫性疾病治療尋找新的干預手段提供了理論基礎。
Objective To investigate the morbidity and mortality of malignant tumors in Chengdu, and get to know their epidemiological characteristics and trends, so as to provide evidence for the policy-making of tumor prevention and control. Methods The ICD-10 coding method was used to analyze the morbidity and mortality of malignant tumors in different ages, genders, areas and types, based on the surveillance data in Chengdu collected from 1990 to 2010. Results The reporting morbidity rose from 32.29/100 000 in 1990 to 171.63/100 000 in 2010, while the reporting mortality rose from 87.03/100 000 in 1990 to 177.51/100 000 in 2010. Liver cancer was seen with the highest morbidity and mortality rate in Chengdu in 2010. The mortality of cancer was higher in male than in female (233.49/100 000 vs. 121.12/100 000). No significant differences were observed between city and rural areas (177.84/100 000 vs. 176.95/100 000). Conclusion The morbidity and mortality rates of tumor are rising year by year, and tumor has become the main disease threatening people’s health. It is suggested that earlier prevention and control measures should be implemented as soon as possible.
Objective To retrospectively analyze the morbidity, mortality, epidemiologic trends and distribution characteristic of top-three malignant tumors in Chengdu from 1990 to 2010, and to be aware of the incidence risk factors, and types and syn-position of main tumors, so as to provide evidence for the policy-making of tumor prevention and control. Methods ICD-10 coding method was used to categorize diseases and analyze the morbidity and mortality of malignant tumors seen in different ages, genders, areas and types, based on the surveillance data in Chengdu collected since 1990. Results The morbidity reports of top-three malignant tumors in Chengdu from 1999 to 2010 were lung cancer, liver cancer and colorectal cancer, the same as the mortality reports from 1999 to 2005, But the mortality of gastric cancer exceeded that of colorectal cancer and ranked as the third from 2005 to 2010. The mortality of top-three malignant tumors in male patients was higher than those in female patients. No difference was observed between urban and rural areas. The mortality of main malignant tumors rose along with the age growth. Conclusion Lung cancer, liver cancer and gastric cancer have become the main malignant tumors threatening Chengdu civilians, and their morbidity and mortality are rising yearly, which suggests that the prevention and control measures such as early diagnosis and treatment should be implemented aiming directly at those main tumors.
Objective To explore the source and distribution of patients with multidrug resistant organisms (MDROs) acquired (infections/colonizations) outside the hospital and to provide a reference for guiding proactive interventions for nosocomial transmission of MDROs. Methods Bacterial culture results and clinical data of patients newly admitted to Beijing Anzhen Nanchong Hospital of Capital Medical University & Nanchong Central Hospita1 were retrospectively investigated between January 1st 2022 and December 31st 2023. The types of MDROs infections/colonizations, patient sources, and triple distributions of patients with nosocomial acquisition of MDROs were analyzed. Results A total of 293 patients with 308 infections/colonizations were investigated in the extranocomial infection of MDROs, 198110 newly admitted patients during the same period, and the total case rate of extranocomial infection of MDROs was 0.155% (308/198110). Among them, the case rate of extranocomial infection of methicillin-resistant Staphylococcus aureus (0.062%) and carbapenem resistant Acinetobacter baumannii (0.044%) were higher than those of other types of bacteria. The case rate of extranocomial infection of MDROs was statistically significant in terms of the distribution of the route of admission, gender of the patient, age of the patient, department of admission, and time of admission (P<0.001); The distribution of patients with extranocomial infection of various types of MDROs was correlated with admission route, patient age, and admission department (P<0.001), and the associations with patient gender and admission time were not statistically significant (P>0.05). Conclusions The total case rate of extranocomial infection of MDROs in the institution was at a relatively low level, and conducting large-scale active screening has certain limitations. Active screening factors should be considered in a comprehensive manner to capture differences in epidemiological characteristics of patients with extranocomial infection of MDROs, and targeted prevention and intervention should be carried out to achieve a reduction in infections from MDROs in hospitals.