1976年Sporn等[1]提出“化學預防（chemoprevention）”的概念，指用化學藥物和飲食來干預腫瘤的發生過程，從而降低腫瘤的發生危險。化學預防對乳腺癌、結腸癌和前列腺癌等腫瘤的作用已有很多的研究，并取得了一些可喜的進展，但在肺癌領域進展甚微。1996年在《新英格蘭醫學雜志》上發表的b-胡蘿卜素聯合維生素A用于肺癌化學預防的報道[2]，讓人大失所望。曾經認為β-胡蘿卜素和維生素A具有“抗癌”作用，這項研究發現用β-胡蘿卜素和維生素A長期干預肺癌高危人群，干預組患肺癌的相對風險顯著高于安慰劑對照組，相對風險為1.28（95％可信區間1.04~1.57，P=0.02），肺癌發生的風險不降反升。最新的Meta分析資料也顯示β-胡蘿卜素增加吸煙者患肺癌的風險[3]。近年來肺癌的化學預防研究一直處于“低谷”之中。
Citation：
WANG Changzhen. Lung Cancer Chemoprevention with Inhaled Corticosteroids?. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(3): 161-162. doi:
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Copyright ? the editorial department of Chinese Journal of Respiratory and Critical Care Medicine of West China Medical Publisher. All rights reserved
| 1. |
Sporn MB，Dunlop NM，Newton DL，et al.Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids).Fed Proc，1976，35：1332-1338.
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| 2. |
Omenn GS，Goodman GE，Thornquist MD，et al.Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease.N Engl J Med，1996，334：1150-1155.
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| 3. |
Tanvetyanon T，Bepler G.Beta-carotene in multivitamins and the possible risk of lung cancer among smokers versus former smokers：a meta-analysis and evaluation of national brands.Cancer. 2008 Apr 21 Epub ahead of print.
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| 4. |
Parimon T，Chien JW，Bryson CL，et al.Inhaled corticosteroids and risk of lung cancer among patients with chronic obstructive pulmonary disease.Am J Respir Crit Care Med，2007，175：712-719.
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| 5. |
Khan A，Agarwal R.Lung Cancer Chemoprevention with Inhaled Corticosteroids? Am J Respir Crit Care Med，2007，176：1169.
|
| 6. |
Buring JE，Hennekens CH.beta-carotene and cancer chemoprevention.J Cell Biochem Suppl， 1995，22：226-230.
|
- 1. Sporn MB，Dunlop NM，Newton DL，et al.Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids).Fed Proc，1976，35：1332-1338.
- 2. Omenn GS，Goodman GE，Thornquist MD，et al.Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease.N Engl J Med，1996，334：1150-1155.
- 3. Tanvetyanon T，Bepler G.Beta-carotene in multivitamins and the possible risk of lung cancer among smokers versus former smokers：a meta-analysis and evaluation of national brands.Cancer. 2008 Apr 21 Epub ahead of print.
- 4. Parimon T，Chien JW，Bryson CL，et al.Inhaled corticosteroids and risk of lung cancer among patients with chronic obstructive pulmonary disease.Am J Respir Crit Care Med，2007，175：712-719.
- 5. Khan A，Agarwal R.Lung Cancer Chemoprevention with Inhaled Corticosteroids? Am J Respir Crit Care Med，2007，176：1169.
- 6. Buring JE，Hennekens CH.beta-carotene and cancer chemoprevention.J Cell Biochem Suppl， 1995，22：226-230.
