Objective To explore the clinical epidemiological characteristics of the lung infection after orthotopical liver transplantation. Methods The clinical data included infection morbidity, mortality, infectious times and relative factors, clinical manifestations, the bacterial strains and distributions of the pathogens, the bacterial resistances of the 53 liver transplantation recipients from 2003.3~2006.12 were summarized and analyzed retrospectively. Results Among 53 recipients, 33 developed lung infectious and 6 died .The mobidity was 62.3% and mortality was 18.2%, with a OR of 1.0. Lung infection predominantly occurred in the first month, especially in the first week after transplantation.There were many factors related to lung infections.Various pathogens, especially Klebsialla, Escherichia Coli and Staphylococus Hominis were isolated from sputum, airway suction drainages and throat swabs. Most of the G- bacteria were sensitive to aminoglycosides,β lactam and lactamase compounds and carbapenems while G+ bacteria were sensitive only to glycopeptides. All the bacteria were resistant to quinolones, β lactams of third and forth generation. Conclusions After liver transplantation, the morbidity and mortality of the lung infections are high.The infections develope at earlier stage, manifest nontypical clinical features.Many factors are revealed to be relevant to the lung infections,meanwhile, various drug-resistant pathogen strains are isolated.
Citation:
LIU Shuren,LUO Xiangrong,LOU Liming,YU Zhouyao,LI Zhuoliang.. The epidemiological characteristics of the lung infection after liver transplantation. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(1): 35-39. doi:
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Copyright ? the editorial department of Chinese Journal of Respiratory and Critical Care Medicine of West China Medical Publisher. All rights reserved
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王槐志,董家鴻,盧倩,等.25例肝移植術后肺部感染臨床分析.中華醫院感染雜志,2004,14:624-626.
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張杏怡,蔡春,王妍,等.肝移植術后肺部感染60例臨床分析.中國抗感染化療雜志,2004,4:328-331.
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喬志明,錢海鑫,周曉俊,等.原位肝移植術后細菌感染的分析.蘇州大學學報(醫學版),2006,26:491-493.
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郭海英,張杏怡,蔡春,等.肝移植術后肺部感染60例臨床分析.中國抗感染化療雜志,2004,4:328-331.
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王秀香,孫德俊,郭宏,等.醫院內肺部感染的致病菌及耐藥性分析.中國呼吸與危重監護雜志,2003,2:308,299.
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| 11. |
謝建國,嚴律南,李波,等.原位肝移植術后肺部感染與易感因素分析.中華器官移植雜志,2005,26:584-586.
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盧倩,閆軍,王曙光,等.肝臟移植術后肺部感染病原體調查及危險因素分析.消化外科,2004,3:153-156.
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| 13. |
孟祥紅,董梅,匡鐵吉,等.肝移植術后感染細菌耐藥性分析.中國誤診學雜志,2006,6:2049-2051.
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黃偉,教鳴,王晶,等.重癥監護病房中產超廣譜β-內酰胺酶革蘭陰性細菌致院內感染的臨床調查.中國呼吸與危重監護雜志,2003,2:291-293.
|
- 1. Mack CL,Millis JM,Whitington PF,et al.Pulmonary complications following liver transplantation in pediatric patients.Pediatr Transplant,2000,4:39-44.
- 2. 李寧,陳惠德,郎韌,等.肝移植術后肺部感染的預防.中華醫院感染學雜志,2001,11:324-426.
- 3. 中華人民共和國衛生部.醫院感染診斷標準(試行).中華醫學雜志,2001,81:314-320.
- 4. 中華醫學會呼吸病學分會.醫院內獲得性肺炎診斷和治療指南(草案).中華結核和呼吸雜志,1999,22:201-203.
- 5. Singh N,Gayowski T,Rihs JD,et al.Evolving trends in multiple-antibiotic-resistant bacteria in liver transplant recipients:a longitudinal study of antimicrobial susceptibility patterns.Liver Transpl,2001,7:22-26.
- 6. 王槐志,董家鴻,盧倩,等.25例肝移植術后肺部感染臨床分析.中華醫院感染雜志,2004,14:624-626.
- 7. 張杏怡,蔡春,王妍,等.肝移植術后肺部感染60例臨床分析.中國抗感染化療雜志,2004,4:328-331.
- 8. 喬志明,錢海鑫,周曉俊,等.原位肝移植術后細菌感染的分析.蘇州大學學報(醫學版),2006,26:491-493.
- 9. 郭海英,張杏怡,蔡春,等.肝移植術后肺部感染60例臨床分析.中國抗感染化療雜志,2004,4:328-331.
- 10. 王秀香,孫德俊,郭宏,等.醫院內肺部感染的致病菌及耐藥性分析.中國呼吸與危重監護雜志,2003,2:308,299.
- 11. 謝建國,嚴律南,李波,等.原位肝移植術后肺部感染與易感因素分析.中華器官移植雜志,2005,26:584-586.
- 12. 盧倩,閆軍,王曙光,等.肝臟移植術后肺部感染病原體調查及危險因素分析.消化外科,2004,3:153-156.
- 13. 孟祥紅,董梅,匡鐵吉,等.肝移植術后感染細菌耐藥性分析.中國誤診學雜志,2006,6:2049-2051.
- 14. 黃偉,教鳴,王晶,等.重癥監護病房中產超廣譜β-內酰胺酶革蘭陰性細菌致院內感染的臨床調查.中國呼吸與危重監護雜志,2003,2:291-293.