Objective To investigate the relationship among rats′ stress ulcer and gastric acid, prostaglandin (PGs) and adrenocorticotropin (ACTH) and to probe the pathogenesis, prophylaxis and therapy.
Methods Rats′ stress ulcer model was made by cold water soaking and was properly treated with drugs such as hyoscine, dexamethasone, ranitidine and losec. The amount and pH of gastric juice, change of gastric mucosa and PGs and ACTH of blood were determined.
Results After rats were fasted for 24 hours a little gastric juice was aspirated. After cold water soaking of rats gastric juice was increased with the pH decreased, there was gastric mucosal bleeding, blood PGs was decreased and ACTH was increased. These suggest that on stress gastric mucosa bleeding is related with decreased gastric juice pH, decreased PGs and increase ACTH.
Conclusion To control stress ulcer, pH of gastric juice and amount of PGs should be increased. Losec can increase gastric juice pH, so losec is the first choice to control stress ulcer.
Citation：
LI Xun,YU Anguo,DENG Zhenping,et al.. STUDY ON PATHOGENESIS AND TREATMENT OF STRESS ULCER IN RATS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(3): 138-140. doi:
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Copyright ? the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
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- 1. 宗育杉， 吳勝群， 李志軍等. 大鼠應激性潰瘍發病機制及其預防方法的研究〔Ｊ〕. 中國危重病急救醫學， 1995； 7(5)∶265.
- 2. 涂易正， 鄭扶民. 冷拘束大鼠應激性潰瘍的發病機制和藥物的預防作用 〔Ｊ〕. 中華實驗外科雜志， 1988； 5(3)∶107.
- 3. 應景， 華積德. 應激性潰瘍的發病機制及其預防 〔Ｊ〕. 普外臨床， 1988； 3(2)∶116.
- 4. Arakawa T, Higuchi K, Fukuda T, et al. Prostaglandins in the stomach: an update 〔Ｊ〕. J Clin Gastroenterol, 1998; 27(Supp 1)∶51.
- 5. Hisato K, Motohatsu F, Yoshitsugu O. Effect of water immersior stress on gastres secretioranc maecsal blood flow in rats 〔Ｊ〕. Gastroenterotogy, 1979; 77(2)∶298.
- 6. Kivilaakso E. Pathogenetic mechanisms in experimental gastric stress ulceration 〔Ｊ〕. Scand J Gastroenterol, 1985; 20(Supp 110)∶57.
- 7. 萬軍利. 應激性潰瘍的形成機制 〔Ｊ〕. 中國病理生理雜志， 1993；9(5)∶664.
- 8. 李兆申， 許國銘， 龔彪等. 洛賽克對大鼠胃粘膜血流量的影響及對應激性潰瘍的預防實驗研究 〔Ｊ〕. 內鏡， 1992； 9(1)∶33.
