STUDIES ON THE ETIOLOGY OF PRIMARY INTRAHEPATIC STONE_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

HUANG Jianhua , L Xinsheng.

Department of Surgery, Xiangya Affiliated Hospital, Hunan University of Medical Sciences, Changsha 410008;

Corresponding?author：

Keywords：

Intrahepatic stone Etiology

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Objective To study the etiology of primary intrahepatic stones.
Methods The literatures in the recent years on the etiology of intrahepatic stone were revieved.
Results The formation of intrahepatic stone mainly caused by bacteria infection, parasitic infestation, bile stasis, congenital anatomic abnormalities and immunoreaction of bile tract. Further investigation found that metabolic, low protein diet, environment and ethnic factors and gene mutation were considered to play important roles in the formation of the intrahepatic stone.
Conclusion The formation of intrahepatic stone is complex and are result of multiple factors. It closely related to the infection and stasis of the bile duct.

Citation： HUANG Jianhua,L Xinsheng.. STUDIES ON THE ETIOLOGY OF PRIMARY INTRAHEPATIC STONE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(2): 125-127. doi: Copy

1.	Pitt HA, Venbrux AC, Coleman JA, et al. Intrahepatic stones: the transhepatic team approach 〔Ｊ〕. Ann Surg, 1994; 219(5)∶527.
2.	Suzuki N, Ise H, Shinya F, et al. The etiology of intrahepatic stones 〔Ｊ〕. Jpn J Clin Med, 1987; 45(2)∶163.
3.	顧倬云，黃志強. 中國人膽結石的特點全國11 342例膽結石手術病例臨床調查，中華外科雜志， 1987； 25(3)∶321.
4.	Shibamoto Y, Shibata K, Tsukie E. Etiology of cholelithisais 〔Ｊ〕. Jpn J Clin Med, 1993; 5(1)∶33.
5.	Matsushiro T, Suzuki N, Sato T, et al. Effects of diet on glucaric acid concentration in bile and the formation of calcium bilirubinate gallstones 〔Ｊ〕. Gastroenterology, 1977; 71(4)∶630.
6.	Akiyama T, Nagakawa T, Kanno M, et al. A clinicopathologic study on intrahepatic cholesterol stones 〔Ｊ〕. Jpn J Surg, 1990; 20(5)∶530.
7.	Maki T. Pathogenesis of calcium bilirubinate gallstones: role of E coli βglucuronidase and coagulation by inorganic ions polyelectrocyte and agitation 〔Ｊ〕. Ann Surg, 1966; 164(1)∶90.
8.	Swidsinski A, Ludwig W, Pablig H, et al. Molecular genetic evidence of bacterial colonization of cholesterol gallstones 〔Ｊ〕. Gastroenterology, 1995; 108(3)∶860.
9.	Cetta F. The role of bactera in pigment gallstone diseases 〔Ｊ〕. Ann Surg, 1991; 213(4)∶315.
10.	Ohdan H, Oshiro H, Yamamoto Y, et al. Bactriological investigation of bile in patients with cholelithiasis 〔Ｊ〕. Surg Today, 1993; 23(5)∶390.
11.	Rehnberg O, Haglundu D. Gallstone diseases following or without vagotomy 〔Ｊ〕. Ann Surg, 1985; 201(3)∶315.
12.	Hawse RH, Cotton PB, Vallon AG. Follow up 6 to 11 years after duodenoscopic sphincterotomy for stones in patients with perior cholecystectomy 〔Ｊ〕. Gastroenterology, 1990; 98(4)∶1008.
13.	Leung JWC, Sung JY, Costerton JW, et al. Bacteriological and election microscopy examination of brown pigment stones 〔Ｊ〕. J Clin Microbiol, 1989; 27(5)∶915.
14.	Kim MH, Lee SK, Min YII, et al. Expandable metallic stents: in the benign strictures of intrahepatic ducts in patients with primary intrahepatic stones 〔Ｊ〕. Dig Endoscopy, 1993; 5(1)∶67.
15.	Imanoglu K, Yonehiro EG, Perry JF, et al. Formation of calculi following cholecystectomy attending partial occlusion of the common bile duct 〔Ｊ〕. Surg Forum, 1957; 8(2)∶225.
16.	Jan YY, Chen MF. Percutaneous transhepatic cholangioscopic lithotomy for hepatolithiasis: longterm result 〔Ｊ〕. Gastrointest Endosc, 1995; 42(1)∶1.
17.	Stock FE, Fung JHY. Oriental cholangiohepatitis 〔Ｊ〕. Arch Surg, 1962; 84(4)∶409.
18.	黃志強主編. 黃志強膽道外科學. 濟南：山東科學技術出版社， 1998∶534～537.
19.	Nakayama Y, Koga A. Hepatolithiasis: present status 〔Ｊ〕. World J Surg, 1984; 8(1)∶9.
20.	Nakanuma Y, Yamaguchi K, Ohta K, et al. Pathology of hepatolithiasis in Japan 〔Ｊ〕. J Biliary Tract Pancreas, 1989; 10(6)∶1301.
21.	張圣道，韓天權. 膽結石研究的展望. 外科理論與實踐， 1999； 4(1)∶5.
22.	Kano M, Shoda J, Irimura T, et al. Effects of longterm ursodeoxycholate administration on expression levels of secretory lowmolecularweight phospholopase A2 and mucin genes in gallbladders and biliary composition in patients with multiple cholesterol stones 〔Ｊ〕. Hepatology, 1998; 28(2)∶302.
23.	蔣兆彥，韓天權，所廣軍等. 膽囊結石病人Apo B基因Xba I多態性及其與血脂的關系. 外科理論與實踐，1999； 4(1)∶18.
24.	宋堅，韓天權，陳勝等. 膽石病患者膽囊收縮素受體與膽囊動力關系的研究. 外科理論與實踐， 1999； 4(1)∶24.
25.	Shoda J, Kano M, Asano T, et al. Secretory lowmolecularweight phospholipases A2 and their specific receptor in bile ducts of patients with intrahepatic calculi: factors of chronic proliferative cholangitis 〔Ｊ〕. Hepatology, 1999; 29(4)∶1026.
26.	冉崇福，楊可楨，韓本立等. 兔膽色素結石中Ag特異性IgG的檢測及意義. 中華肝膽外科雜志， 1999； 5(2)∶114.
27.	Sheen Chen SM, Eng HL, Chou FF, et al. Serumsoluble interleukin2 receptor in patients with hepatolithiasis: a prelimary report 〔Ｊ〕. Hepatogastroenterology, 1998; 45(19)∶196.
28.	Shoda J, Tanada N, He BF, et al. Alterations of bile acid composition in gallstones, bile and liver of patients with hepatolithiasis and their etiological significance 〔Ｊ〕. Dig Dis Sci, 1993; 38(11)∶2130.

1. Pitt HA, Venbrux AC, Coleman JA, et al. Intrahepatic stones: the transhepatic team approach 〔Ｊ〕. Ann Surg, 1994; 219(5)∶527.
2. Suzuki N, Ise H, Shinya F, et al. The etiology of intrahepatic stones 〔Ｊ〕. Jpn J Clin Med, 1987; 45(2)∶163.
3. 顧倬云，黃志強. 中國人膽結石的特點全國11 342例膽結石手術病例臨床調查，中華外科雜志， 1987； 25(3)∶321.
4. Shibamoto Y, Shibata K, Tsukie E. Etiology of cholelithisais 〔Ｊ〕. Jpn J Clin Med, 1993; 5(1)∶33.
5. Matsushiro T, Suzuki N, Sato T, et al. Effects of diet on glucaric acid concentration in bile and the formation of calcium bilirubinate gallstones 〔Ｊ〕. Gastroenterology, 1977; 71(4)∶630.
6. Akiyama T, Nagakawa T, Kanno M, et al. A clinicopathologic study on intrahepatic cholesterol stones 〔Ｊ〕. Jpn J Surg, 1990; 20(5)∶530.
7. Maki T. Pathogenesis of calcium bilirubinate gallstones: role of E coli βglucuronidase and coagulation by inorganic ions polyelectrocyte and agitation 〔Ｊ〕. Ann Surg, 1966; 164(1)∶90.
8. Swidsinski A, Ludwig W, Pablig H, et al. Molecular genetic evidence of bacterial colonization of cholesterol gallstones 〔Ｊ〕. Gastroenterology, 1995; 108(3)∶860.
9. Cetta F. The role of bactera in pigment gallstone diseases 〔Ｊ〕. Ann Surg, 1991; 213(4)∶315.
10. Ohdan H, Oshiro H, Yamamoto Y, et al. Bactriological investigation of bile in patients with cholelithiasis 〔Ｊ〕. Surg Today, 1993; 23(5)∶390.
11. Rehnberg O, Haglundu D. Gallstone diseases following or without vagotomy 〔Ｊ〕. Ann Surg, 1985; 201(3)∶315.
12. Hawse RH, Cotton PB, Vallon AG. Follow up 6 to 11 years after duodenoscopic sphincterotomy for stones in patients with perior cholecystectomy 〔Ｊ〕. Gastroenterology, 1990; 98(4)∶1008.
13. Leung JWC, Sung JY, Costerton JW, et al. Bacteriological and election microscopy examination of brown pigment stones 〔Ｊ〕. J Clin Microbiol, 1989; 27(5)∶915.
14. Kim MH, Lee SK, Min YII, et al. Expandable metallic stents: in the benign strictures of intrahepatic ducts in patients with primary intrahepatic stones 〔Ｊ〕. Dig Endoscopy, 1993; 5(1)∶67.
15. Imanoglu K, Yonehiro EG, Perry JF, et al. Formation of calculi following cholecystectomy attending partial occlusion of the common bile duct 〔Ｊ〕. Surg Forum, 1957; 8(2)∶225.
16. Jan YY, Chen MF. Percutaneous transhepatic cholangioscopic lithotomy for hepatolithiasis: longterm result 〔Ｊ〕. Gastrointest Endosc, 1995; 42(1)∶1.
17. Stock FE, Fung JHY. Oriental cholangiohepatitis 〔Ｊ〕. Arch Surg, 1962; 84(4)∶409.
18. 黃志強主編. 黃志強膽道外科學. 濟南：山東科學技術出版社， 1998∶534～537.
19. Nakayama Y, Koga A. Hepatolithiasis: present status 〔Ｊ〕. World J Surg, 1984; 8(1)∶9.
20. Nakanuma Y, Yamaguchi K, Ohta K, et al. Pathology of hepatolithiasis in Japan 〔Ｊ〕. J Biliary Tract Pancreas, 1989; 10(6)∶1301.
21. 張圣道，韓天權. 膽結石研究的展望. 外科理論與實踐， 1999； 4(1)∶5.
22. Kano M, Shoda J, Irimura T, et al. Effects of longterm ursodeoxycholate administration on expression levels of secretory lowmolecularweight phospholopase A2 and mucin genes in gallbladders and biliary composition in patients with multiple cholesterol stones 〔Ｊ〕. Hepatology, 1998; 28(2)∶302.
23. 蔣兆彥，韓天權，所廣軍等. 膽囊結石病人Apo B基因Xba I多態性及其與血脂的關系. 外科理論與實踐，1999； 4(1)∶18.
24. 宋堅，韓天權，陳勝等. 膽石病患者膽囊收縮素受體與膽囊動力關系的研究. 外科理論與實踐， 1999； 4(1)∶24.
25. Shoda J, Kano M, Asano T, et al. Secretory lowmolecularweight phospholipases A2 and their specific receptor in bile ducts of patients with intrahepatic calculi: factors of chronic proliferative cholangitis 〔Ｊ〕. Hepatology, 1999; 29(4)∶1026.
26. 冉崇福，楊可楨，韓本立等. 兔膽色素結石中Ag特異性IgG的檢測及意義. 中華肝膽外科雜志， 1999； 5(2)∶114.
27. Sheen Chen SM, Eng HL, Chou FF, et al. Serumsoluble interleukin2 receptor in patients with hepatolithiasis: a prelimary report 〔Ｊ〕. Hepatogastroenterology, 1998; 45(19)∶196.
28. Shoda J, Tanada N, He BF, et al. Alterations of bile acid composition in gallstones, bile and liver of patients with hepatolithiasis and their etiological significance 〔Ｊ〕. Dig Dis Sci, 1993; 38(11)∶2130.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

STUDIES ON THE ETIOLOGY OF PRIMARY INTRAHEPATIC STONE

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