Relationship Between Histone Modifications and Gastrointestinal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

MENG Chunfeng , DAI Dongqiu

Department of Surgical Oncology, The First Affiliated Hospital, Chinese Medical University, Shenyang 110001, China;

Corresponding?author：

Keywords：

Gastrointestinal cancer; Gene; Histone modification

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective 　To review the relationship between histone modifications and gastrointestinal cancer.
Methods 　Literatures on histone modifications and the relationship between histone modifications and gastrointestinal cancer were collected and reviewed.
Results 　Histone modifications played an important role in the establishment of gene silencing during tumorgenesis. DNA methylation and histone modifications might interact with each other and form a complex network to establish and maintain gene silencing. Restoring gene function silenced by epigenetic changes in cancer had the potential of ‘normalizing’ cancer cells, which was named epigenetic therapy. Epigenetic therapy was very promising in prevention and treatment of gastrointestinal cancer, but many unsolved issues remain which need to be addressed in future studies.
Conclusion　 Histone modifications are associated with the pathogenesis of gastrointestinal cancer. Restoring gene function silenced by epigenetic changes may have a great role in the prevention and treatment of gastrointestinal cancer.

Citation： MENG Chunfeng,DAI Dongqiu. Relationship Between Histone Modifications and Gastrointestinal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2007, 14(5): 608-611. doi: Copy

1.	Wolffe AP, Matzke MA. Epigenetics: regulation through repression [J]. Science， 1999; 286(5439)∶481.
2.	Feinberg AP, Vogelstein B. Hypomethylation distinguishes ge-nes of some human cancers from their normal counterparts [J]. Nature， 1983; 301(5895)∶89.
3.	Strahl BD, Allis CD. The language of covalent histone modifications [J]. Nature， 2000; 403(6765)∶41.
4.	楊少輝，戴冬秋. 腫瘤抑制基因甲基化與胃癌 [J]. 中國普外基礎與臨床雜志， 2006； 13（5）∶614.
5.	Rea S, Eisenhaber F, O’Carroll D, et al. Regulation of chromatin structure by site-specific histone H3 methyltransferases [J]. Nature， 2000; 406(6796)∶593.
6.	Jenuwein T, Allis CD. Translating the histone code [J]. Science， 2001; 293(5532)∶1074.
7.	Wang H, Cao R, Xia L, et al. Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase [J]. Mol Cell， 2001; 8(6)∶1207.
8.	Schubeler D, MacAlpine DM, Scalzo D, et al. The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote [J]. Genes Dev， 2004; 18(11)∶1263.
9.	Liang G, Lin JC, Wei V, et al. Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome [J]. Proc Natl Acad Sci USA， 2004; 101(19)∶7357.
10.	Shi Y, Lan F, Matson C, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1 [J]. Cell， 2004; 119(7)∶941.
11.	Mahadevan LC, Willis AC, Barratt MJ. Rapid histone H3 ph-osphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors [J]. Cell， 1991; 65(5)∶775.
12.	Nowak SJ, Corces VG. Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation [J]. Trends Genet， 2004; 20(4)∶214.
13.	Salvador LM, Park Y, Cottom J, et al. Follicle-stimulating hormone stimulates protein kinase A-mediated histone H3 phosphorylation and acetylation leading to select gene activation in ovarian granulosa cells [J]. J Biol Chem， 2001; 276(43)∶40146.
14.	Cheung P, Allis CD, Sassone-Corsi P. Signaling to chromatin through histone modifications [J]. Cell， 2000; 103(2)∶263.
15.	Nowak SJ, Corces VG. Phosphorylation of histone H3 correlates with transcriptionally active loci [J]. Genes Dev， 2000; 14(23)∶3003.
16.	Cameron EE, Bachman KE, Myohanen S, et al. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer [J]. Nat Genet， 1999; 21(1)∶103.
17.	Kondo Y, Shen L, Issa JP. Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer [J]. Mol Cell Biol， 2003; 23(1)∶206.
18.	Fahrner JA, Eguchi S, Herman JG, et al. Dependence of histone modifications and gene expression on DNA hypermethylation in cancer [J]. Cancer Res， 2002; 62(24)∶7213.
19.	Fuks F， Hurd PJ， Wolf D， et al. The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation [J]. J Biol Chem， 2003; 278(6)∶4035.
20.	Bachman KE, Park BH, Rhee I, et al. Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene [J]. Cancer Cell， 2003; 3(1)∶89.
21.	Cheung P, Tanner KG, Cheung WL, et al. Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation [J]. Mol Cell， 2000; 5(6)∶905.
22.	Lo WS, Trievel RC, Rojas JR, et al. Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14 [J]. Mol Cell， 2000; 5(6)∶917.
23.	Zhang Y, Reinberg D. Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails [J]. Genes Dev， 2001; 15(18)∶2343.
24.	Wang H, Huang ZQ, Xia L, et al. Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor [J]. Science， 2001; 293(5531)∶853.
25.	Fang JY, Chen YX, Lu J, et al. Epigenetic modification regulates both expression of tumor-associated genes and cell cycle progressing in human colon cancer cell lines: Colo-320 and SW1116 [J]. Cell Res， 2004; 14(3)∶217.
26.	Mitani Y, Oue N, Hamai Y, et al. Histone H3 acetylation is associated with reduced p21(WAF1/CIP1) expression by gastric carcinoma [J]. J Pathol， 2005; 205(1)∶65.
27.	Hamai Y, Oue N, Mitani Y, et al. DNA hypermethylation and histone hypoacetylation of the HLTF gene are associated with reduced expression in gastric carcinoma [J]. Cancer Sci， 2003; 94(8)∶692.
28.	Loprevite M, Tiseo M, Grossi F, et al. In vitro study of CI-994, a histone deacetylase inhibitor, in non-small cell lung cancer cell lines [J]. Oncol Res， 2005; 15(1)∶39.
29.	Egger G, Liang G, Aparicio A, et al. Epigenetics in human disease and prospects for epigenetic therapy [J]. Nature， 2004; 429(6990)∶457.
30.	Dobosy JR, Roberts JL, Fu VX, et al. The expanding role of epigenetics in the development, diagnosis and treatment of prostate cancer and benign prostatic hyperplasia [J]. J Urol， 2007; 177(3)∶822.
31.	Kaminskas E, Farrell A, Abraham S, et al. Approval summary: azacitidine for treatment of myelodysplastic syndrome subtypes [J]. Clin Cancer Res, 2005; 11(10)∶3604.

1. 　Wolffe AP, Matzke MA. Epigenetics: regulation through repression [J]. Science， 1999; 286(5439)∶481.
2. 　Feinberg AP, Vogelstein B. Hypomethylation distinguishes ge-nes of some human cancers from their normal counterparts [J]. Nature， 1983; 301(5895)∶89.
3. 　Strahl BD, Allis CD. The language of covalent histone modifications [J]. Nature， 2000; 403(6765)∶41.
4. 　楊少輝，戴冬秋. 腫瘤抑制基因甲基化與胃癌 [J]. 中國普外基礎與臨床雜志， 2006； 13（5）∶614.
5. 　Rea S, Eisenhaber F, O’Carroll D, et al. Regulation of chromatin structure by site-specific histone H3 methyltransferases [J]. Nature， 2000; 406(6796)∶593.
6. 　Jenuwein T, Allis CD. Translating the histone code [J]. Science， 2001; 293(5532)∶1074.
7. 　Wang H, Cao R, Xia L, et al. Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase [J]. Mol Cell， 2001; 8(6)∶1207.
8. 　Schubeler D, MacAlpine DM, Scalzo D, et al. The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote [J]. Genes Dev， 2004; 18(11)∶1263.
9. 　Liang G, Lin JC, Wei V, et al. Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome [J]. Proc Natl Acad Sci USA， 2004; 101(19)∶7357.
10. 　Shi Y, Lan F, Matson C, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1 [J]. Cell， 2004; 119(7)∶941.
11. 　Mahadevan LC, Willis AC, Barratt MJ. Rapid histone H3 ph-osphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors [J]. Cell， 1991; 65(5)∶775.
12. 　Nowak SJ, Corces VG. Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation [J]. Trends Genet， 2004; 20(4)∶214.
13. 　Salvador LM, Park Y, Cottom J, et al. Follicle-stimulating hormone stimulates protein kinase A-mediated histone H3 phosphorylation and acetylation leading to select gene activation in ovarian granulosa cells [J]. J Biol Chem， 2001; 276(43)∶40146.
14. 　Cheung P, Allis CD, Sassone-Corsi P. Signaling to chromatin through histone modifications [J]. Cell， 2000; 103(2)∶263.
15. 　Nowak SJ, Corces VG. Phosphorylation of histone H3 correlates with transcriptionally active loci [J]. Genes Dev， 2000; 14(23)∶3003.
16. 　Cameron EE, Bachman KE, Myohanen S, et al. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer [J]. Nat Genet， 1999; 21(1)∶103.
17. 　Kondo Y, Shen L, Issa JP. Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer [J]. Mol Cell Biol， 2003; 23(1)∶206.
18. 　Fahrner JA, Eguchi S, Herman JG, et al. Dependence of histone modifications and gene expression on DNA hypermethylation in cancer [J]. Cancer Res， 2002; 62(24)∶7213.
19. 　Fuks F， Hurd PJ， Wolf D， et al. The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation [J]. J Biol Chem， 2003; 278(6)∶4035.
20. 　Bachman KE, Park BH, Rhee I, et al. Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene [J]. Cancer Cell， 2003; 3(1)∶89.
21. 　Cheung P, Tanner KG, Cheung WL, et al. Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation [J]. Mol Cell， 2000; 5(6)∶905.
22. 　Lo WS, Trievel RC, Rojas JR, et al. Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14 [J]. Mol Cell， 2000; 5(6)∶917.
23. 　Zhang Y, Reinberg D. Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails [J]. Genes Dev， 2001; 15(18)∶2343.
24. 　Wang H, Huang ZQ, Xia L, et al. Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor [J]. Science， 2001; 293(5531)∶853.
25. 　Fang JY, Chen YX, Lu J, et al. Epigenetic modification regulates both expression of tumor-associated genes and cell cycle progressing in human colon cancer cell lines: Colo-320 and SW1116 [J]. Cell Res， 2004; 14(3)∶217.
26. 　Mitani Y, Oue N, Hamai Y, et al. Histone H3 acetylation is associated with reduced p21(WAF1/CIP1) expression by gastric carcinoma [J]. J Pathol， 2005; 205(1)∶65.
27. 　Hamai Y, Oue N, Mitani Y, et al. DNA hypermethylation and histone hypoacetylation of the HLTF gene are associated with reduced expression in gastric carcinoma [J]. Cancer Sci， 2003; 94(8)∶692.
28. 　Loprevite M, Tiseo M, Grossi F, et al. In vitro study of CI-994, a histone deacetylase inhibitor, in non-small cell lung cancer cell lines [J]. Oncol Res， 2005; 15(1)∶39.
29. 　Egger G, Liang G, Aparicio A, et al. Epigenetics in human disease and prospects for epigenetic therapy [J]. Nature， 2004; 429(6990)∶457.
30. 　Dobosy JR, Roberts JL, Fu VX, et al. The expanding role of epigenetics in the development, diagnosis and treatment of prostate cancer and benign prostatic hyperplasia [J]. J Urol， 2007; 177(3)∶822.
31. 　 Kaminskas E, Farrell A, Abraham S, et al. Approval summary: azacitidine for treatment of myelodysplastic syndrome subtypes [J]. Clin Cancer Res, 2005; 11(10)∶3604.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship Between Histone Modifications and Gastrointestinal Cancer

Abstract Full text Figures/Tables Video References Cited by

Format

Content