Effect of Tumor Necrosis Factor-α and Interleukin in Acute Pancreatitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

XU Yanjun ¹ , WU Xinmin ² , GUO Yamin ²

1.Graduate College of Medical College of Qinghai University, Xining 810001, China;;
2.Department of General Surgery, People’s Hospital of Qinghai Province, Xining 810007, China;

Corresponding?author：

Keywords：

Acute pancreatitis; Cytokine; Tumor necrosis factor-α; Interleukin

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Objective To summarize the change in the cytokine network, the classification of various cytokines, interaction, and systemic impact on patients with acute pancreatitis (AP).
Methods The recently published literatures in domestic and abroad about advancement of cytokines in AP were reviewed.
Results Cytokines had a complex network and interactions. There were a variety of regulatory mechanisms. The tumor necrosis factor-α (TNF-α) and interleukin cytokines played important roles in the progress of AP. Conclusions Change of cytokines during AP is a complex process. Any separate regulation for the release of sigle factor has no significant effect on the disease. The treatment according to immune balance should be a better direction.

Citation： XU Yanjun ,WU Xinmin,GUO Yamin. Effect of Tumor Necrosis Factor-α and Interleukin in Acute Pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(9): 993-996. doi: Copy

1.	Rinderknecht H. Fatal pancreatitis, a consequence of excessive leukocyte stimulation? [J]. Int J Pancreatol, 1988; 3(23): 105112.
2.	Bhatia M. Acute pancreatitis as a model of SIRS [J]. Front Biosci, 2009; 14: 20422050.
3.	Stimac D, Fisi E, Mili S, et al. Prognostic values of IL6, IL8, and IL10 in acute pancreatitis [J]. J Clin Gastroenterol, 2006; 40(3): 209212.
4.	Ramudo L, Manso MA, De Dios I. Biliary pancreatitisassociated ascitic fluid activates the production of tumor necrosis factoralpha in acinar cells [J]. Crit Care Med, 2005; 33(1): 143148.
5.	Norman JG, Fink GW, Franz MG. Acute pancreatitis induces intrapancreatic tumor necrosis factor gene expression [J]. Arch Surg, 1995; 130(9): 966970.
6.	Gulcubuk A, Altunatmaz K, Sonmez K, et al. Effects of curcumin on tumour necrosis factorα and interleukin6 in the late phase of experimental acute pancreatitis [J]. J Vet Med A Physiol Pathol Clin Med, 2006; 53(1): 4954.
7.	林錚, 陳維雄. 粘附分子、炎癥介質及細胞因子在急性胰腺炎中的作用研究進展 [J]. 國外醫學消化系疾病分冊, 2001; 211(3): 180183.
8.	秦仁義, 裘法祖. 炎癥介質、細胞因子在急性壞死性胰腺炎發生發展中的作用 [J]. 中國普外基礎與臨床雜志, 1998; 5(6): 361362.
9.	張欣中, 葉子. 急性胰腺炎患者腸道屏障保護和炎性反應調控的研究 [J]. 中國微生態學雜志, 2008; 20(2): 186188.
10.	雷若慶, 韓天權, 湯耀卿, 等. TNFα在重癥急性胰腺炎致病機制中的作用 [J]. 上海第二醫科大學學報， 2000; 20(1): 14.
11.	Thuijls G, de Haan JJ, Derikx JP, et al. Intestinal cytoskeleton degradation precedes tight junction loss following hemorrhagic shock [J]. Shock, 2009; 31(2): 164169.
12.	秦勇, 黨曉燕. 白藜蘆醇對重癥急性胰腺炎大鼠腸黏膜缺血再灌注損傷的保護作用 [J]. 中國普外基礎與臨床雜志, 2009; 16(10): 819823.
13.	Mayer JM. Shifting the focus from leukocyte to acinar cell: which is the more important mediator of pancreatic inflammation? [J]. Crit Care Med, 2005; 33(1): 248.
14.	Ura H, Hirata K, Yamaguchi K, et al. Mechanism of the development of organ failure [J]. Nippon Geka Gakkai Zasshi, 1998; 99(8): 485489.
15.	McKay C, Imrie CW, Baxter JN. Mononuclear phagocyte activation and acute pancreatitis [J]. Scand J Gastroenterol Suppl, 1996; 219: 3236.
16.	Sempere L, Martinez J, de Madaria E, et al. Obesity and fat distribution imply a greater systemic inflammatory response and a worse prognosis in acute pancreatitis [J]. Pancreatology, 2008; 8(3): 257264.
17.	Norman JG, Fink G, Franz M, et al. Active interleukin1 receptor required for maximal progression of acute pancreatitis [J]. Ann Surg, 1996; 223(2): 163169.
18.	Zhang XH, Zhu RM, Xu WA, et al. Therapeutic effects of caspase1 inhibitors on acute lung injury in experimental severe acute pancreatitis [J]. World J Gastroenterol, 2007; 13(4): 623627.
19.	汪寶林, 許利劍, 張建平, 等. 抗細胞因子療法治療實驗性急性壞死性胰腺炎 [J]. 南京醫科大學學報(自然科學版), 2006; 26(1): 5962.
20.	王要軍, 葛文松. TNFα、IL6、TAP與急性胰腺炎嚴重程度的相關性研究 [J]. 中國誤診學雜志, 2009; 9(6): 12611262.
21.	葛全興, 陳墾, 王暉. 炎癥介質在急性胰腺炎發病機制中的作用研究進展 [J]. 廣東藥學院學報, 2008; 24(1): 9295.
22.	Chao KC, Chao KF, Chuang CC, et al. Blockade of interleukin 6 accelerates acinar cell apoptosis and attenuates experimental acute pancreatitis in vivo [J]. Br J Surg, 2006; 93(3): 332338.
23.	賀紅杰, 秦春宏, 張學林, 等. CO2氣腹對大鼠重癥急性胰腺炎胰腺病理及IL1、IL6、CD11a/CD18和CD11b/CD18的影響 [J]. 中國普外基礎與臨床雜志, 2010; 17(2): 147151.
24.	Panek J, Zasada J, Poｚ＇niczek M. Microcirculatory disturbance in the course of acute pancreatitis [J]. Przegl Lek, 2007; 64(6): 435437.
25.	Pooran N, Indaram A, Singh P, et al. Cytokines (IL6, IL8, TNF): early and reliable predictors of severe acute pancreatitis [J]. J Clin Gastroenterol, 2003; 37(3): 263266.
26.	馬云濤, 蘇河, 王曉鵬, 等. 重組干擾素α治療重癥急性胰腺炎效果觀察 [J]. 蘭州大學學報(醫學版), 2009; 35(3): 6063.
27.	肖彥, 王湘英. 重癥急性胰腺炎與炎性細胞因子 [J]. 醫學臨床研究, 2008; 25(4): 703705.
28.	Moore KW, de Waal Malefyt R, Coffman RL, et al. Interleukin10 and the interleukin10 receptor [J]. Annu Rev Immunol, 2001; 19: 683765.
29.	de Waal Malefyt R, Abrams J, Bennett B, et al. Interleukin 10 (IL10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL10 produced by monocytes [J]. J Exp Med, 1991; 174(5): 12091220.
30.	Kusske AM, Rongione AJ, Ashley SW, et al. Interleukin10 prevents death in lethal necrotizing pancreatitis in mice [J]. Surgery, 1996; 120(2): 284288.
31.	姚婷, 王書奎, 陳軍, 等. MCSF、IL10對單核細胞IL12、IL18產生及HLADR和CD80表達的影響 [J]. 細胞與分子免疫學雜志, 2004; 20(1): 6769.
32.	金忱, 倪泉興, 張群華, 等. 急性胰腺炎大鼠TNFα mRNA、IL10 mRNA表達和胰腺細胞凋亡的研究 [J]. 中華外科雜志, 2001; 39(8): 626628.
33.	Pezzilli R, Fantini L, MorselliLabate AM. New approaches for the treatment of acute pancreatitis [J]. JOP, 2006; 7(1): 7991.
34.	Strobel O, Wachter D, Werner J, et al. Effect of a pneumoperitoneum on systemic cytokine levels, bacterial translocation, and organ complications in a rat model of severe acute pancreatitis with infected necrosis [J]. Surg Endosc, 2006; 20(12): 18971903.
35.	Mentula P, Kylnp ML, Kemppainen E, et al. Early prediction of organ failure in acute pancreatitis [J]. Duodecim, 2005; 121(12): 1331.
36.	Devière J, Le Moine O, Van Laethem JL, et al. Interleukin 10 reduces the incidence of pancreatitis after therapeutic endoscopic retrograde cholangiopancreatography [J]. Gastroenterology, 2001; 120(2): 498505.
37.	鐘燕, 蔡東聯, 耿珊珊, 等. 添加低聚半乳糖腸內營養對重癥急性胰腺炎大鼠炎性細胞因子的作用 [J]. 上海交通大學學報（醫學版）, 2009; 29(6): 689692.
38.	Curley PJ. Endotoxin, cellular immune dysfunction and acute pancreatitis [J]. Ann R Coll Surg Engl, 1996; 78(6): 531535.
39.	Curley P, Nestor M, Collins K, et al. Decreased interleukin2 production in murine acute pancreatitis: potential for immunomodulation [J]. Gastroenterology, 1996; 110(2): 583588.
40.	Ma T, Kang C, Shao H, et al. Protective effects of ulinastatin on proliferation and cytokine release of splenocytes from rats with severe acute pancreatitis [J]. Eur Surg Res, 2006; 38(5): 445450.
41.	Ryz NR, Meddings JB, Taylor CG. Longchain inulin increases dendritic cells in the Peyer’s patches and increases ex vivo cytokine secretion in the spleen and mesenteric lymph nodes of growing female rats, independent of zinc status [J]. Br J Nutr, 2009; 101(11): 16531663.
42.	王基, 閆軍. 外源性瘦素在大鼠急性胰腺炎中的保護作用 [J]. 山西醫藥雜志, 2007; 36(3): 215217.
43.	Kilciler G, Musabak U, Bagci S, et al. Do the changes in the serum levels of IL2, IL4, TNFα, and IL6 reflect the inflammatory activity in the patients with postERCP pancreatitis? [J]. Clin Dev Immunol, 2008; 2008: 481560. doi: 10.1155/2008/481560.
44.	Chen CC, Wang SS, Lu RH, et al. Serum interleukin 10 and interleukin 11 in patients with acute pancreatitis [J]. Gut, 1999; 45(6): 895899.
45.	Shimizu T, Shiratori K, Sawada T, et al. Recombinant human interleukin11 decreases severity of acute necrotizing pancreatitis in mice [J]. Pancreas, 2000; 21(2): 134140.
46.	Bone RC. Sir Isaac Newton, sepsis, SIRS, and CARS [J]. Crit Care Med, 1996; 24(7): 11251128.
47.	熊建平, 文軍. 急性胰腺炎中全身炎癥反應綜合征與抗炎癥反應綜合征 [J]. 國際外科學雜志, 2008; 35(9): 628630.
48.	姚欣敏, 劉牧, 李云濤, 等. 早期反復間斷血濾治療重癥急性胰腺炎的臨床研究 [J]. 中國普外基礎與臨床雜志, 2008; 15(5): 352357.

1. Rinderknecht H. Fatal pancreatitis, a consequence of excessive leukocyte stimulation? [J]. Int J Pancreatol, 1988; 3(23): 105112.
2. Bhatia M. Acute pancreatitis as a model of SIRS [J]. Front Biosci, 2009; 14: 20422050.
3. Stimac D, Fisi E, Mili S, et al. Prognostic values of IL6, IL8, and IL10 in acute pancreatitis [J]. J Clin Gastroenterol, 2006; 40(3): 209212.
4. Ramudo L, Manso MA, De Dios I. Biliary pancreatitisassociated ascitic fluid activates the production of tumor necrosis factoralpha in acinar cells [J]. Crit Care Med, 2005; 33(1): 143148.
5. Norman JG, Fink GW, Franz MG. Acute pancreatitis induces intrapancreatic tumor necrosis factor gene expression [J]. Arch Surg, 1995; 130(9): 966970.
6. Gulcubuk A, Altunatmaz K, Sonmez K, et al. Effects of curcumin on tumour necrosis factorα and interleukin6 in the late phase of experimental acute pancreatitis [J]. J Vet Med A Physiol Pathol Clin Med, 2006; 53(1): 4954.
7. 林錚, 陳維雄. 粘附分子、炎癥介質及細胞因子在急性胰腺炎中的作用研究進展 [J]. 國外醫學消化系疾病分冊, 2001; 211(3): 180183.
8. 秦仁義, 裘法祖. 炎癥介質、細胞因子在急性壞死性胰腺炎發生發展中的作用 [J]. 中國普外基礎與臨床雜志, 1998; 5(6): 361362.
9. 張欣中, 葉子. 急性胰腺炎患者腸道屏障保護和炎性反應調控的研究 [J]. 中國微生態學雜志, 2008; 20(2): 186188.
10. 雷若慶, 韓天權, 湯耀卿, 等. TNFα在重癥急性胰腺炎致病機制中的作用 [J]. 上海第二醫科大學學報， 2000; 20(1): 14.
11. Thuijls G, de Haan JJ, Derikx JP, et al. Intestinal cytoskeleton degradation precedes tight junction loss following hemorrhagic shock [J]. Shock, 2009; 31(2): 164169.
12. 秦勇, 黨曉燕. 白藜蘆醇對重癥急性胰腺炎大鼠腸黏膜缺血再灌注損傷的保護作用 [J]. 中國普外基礎與臨床雜志, 2009; 16(10): 819823.
13. Mayer JM. Shifting the focus from leukocyte to acinar cell: which is the more important mediator of pancreatic inflammation? [J]. Crit Care Med, 2005; 33(1): 248.
14. Ura H, Hirata K, Yamaguchi K, et al. Mechanism of the development of organ failure [J]. Nippon Geka Gakkai Zasshi, 1998; 99(8): 485489.
15. McKay C, Imrie CW, Baxter JN. Mononuclear phagocyte activation and acute pancreatitis [J]. Scand J Gastroenterol Suppl, 1996; 219: 3236.
16. Sempere L, Martinez J, de Madaria E, et al. Obesity and fat distribution imply a greater systemic inflammatory response and a worse prognosis in acute pancreatitis [J]. Pancreatology, 2008; 8(3): 257264.
17. Norman JG, Fink G, Franz M, et al. Active interleukin1 receptor required for maximal progression of acute pancreatitis [J]. Ann Surg, 1996; 223(2): 163169.
18. Zhang XH, Zhu RM, Xu WA, et al. Therapeutic effects of caspase1 inhibitors on acute lung injury in experimental severe acute pancreatitis [J]. World J Gastroenterol, 2007; 13(4): 623627.
19. 汪寶林, 許利劍, 張建平, 等. 抗細胞因子療法治療實驗性急性壞死性胰腺炎 [J]. 南京醫科大學學報(自然科學版), 2006; 26(1): 5962.
20. 王要軍, 葛文松. TNFα、IL6、TAP與急性胰腺炎嚴重程度的相關性研究 [J]. 中國誤診學雜志, 2009; 9(6): 12611262.
21. 葛全興, 陳墾, 王暉. 炎癥介質在急性胰腺炎發病機制中的作用研究進展 [J]. 廣東藥學院學報, 2008; 24(1): 9295.
22. Chao KC, Chao KF, Chuang CC, et al. Blockade of interleukin 6 accelerates acinar cell apoptosis and attenuates experimental acute pancreatitis in vivo [J]. Br J Surg, 2006; 93(3): 332338.
23. 賀紅杰, 秦春宏, 張學林, 等. CO2氣腹對大鼠重癥急性胰腺炎胰腺病理及IL1、IL6、CD11a/CD18和CD11b/CD18的影響 [J]. 中國普外基礎與臨床雜志, 2010; 17(2): 147151.
24. Panek J, Zasada J, Poｚ＇niczek M. Microcirculatory disturbance in the course of acute pancreatitis [J]. Przegl Lek, 2007; 64(6): 435437.
25. Pooran N, Indaram A, Singh P, et al. Cytokines (IL6, IL8, TNF): early and reliable predictors of severe acute pancreatitis [J]. J Clin Gastroenterol, 2003; 37(3): 263266.
26. 馬云濤, 蘇河, 王曉鵬, 等. 重組干擾素α治療重癥急性胰腺炎效果觀察 [J]. 蘭州大學學報(醫學版), 2009; 35(3): 6063.
27. 肖彥, 王湘英. 重癥急性胰腺炎與炎性細胞因子 [J]. 醫學臨床研究, 2008; 25(4): 703705.
28. Moore KW, de Waal Malefyt R, Coffman RL, et al. Interleukin10 and the interleukin10 receptor [J]. Annu Rev Immunol, 2001; 19: 683765.
29. de Waal Malefyt R, Abrams J, Bennett B, et al. Interleukin 10 (IL10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL10 produced by monocytes [J]. J Exp Med, 1991; 174(5): 12091220.
30. Kusske AM, Rongione AJ, Ashley SW, et al. Interleukin10 prevents death in lethal necrotizing pancreatitis in mice [J]. Surgery, 1996; 120(2): 284288.
31. 姚婷, 王書奎, 陳軍, 等. MCSF、IL10對單核細胞IL12、IL18產生及HLADR和CD80表達的影響 [J]. 細胞與分子免疫學雜志, 2004; 20(1): 6769.
32. 金忱, 倪泉興, 張群華, 等. 急性胰腺炎大鼠TNFα mRNA、IL10 mRNA表達和胰腺細胞凋亡的研究 [J]. 中華外科雜志, 2001; 39(8): 626628.
33. Pezzilli R, Fantini L, MorselliLabate AM. New approaches for the treatment of acute pancreatitis [J]. JOP, 2006; 7(1): 7991.
34. Strobel O, Wachter D, Werner J, et al. Effect of a pneumoperitoneum on systemic cytokine levels, bacterial translocation, and organ complications in a rat model of severe acute pancreatitis with infected necrosis [J]. Surg Endosc, 2006; 20(12): 18971903.
35. Mentula P, Kylnp ML, Kemppainen E, et al. Early prediction of organ failure in acute pancreatitis [J]. Duodecim, 2005; 121(12): 1331.
36. Devière J, Le Moine O, Van Laethem JL, et al. Interleukin 10 reduces the incidence of pancreatitis after therapeutic endoscopic retrograde cholangiopancreatography [J]. Gastroenterology, 2001; 120(2): 498505.
37. 鐘燕, 蔡東聯, 耿珊珊, 等. 添加低聚半乳糖腸內營養對重癥急性胰腺炎大鼠炎性細胞因子的作用 [J]. 上海交通大學學報（醫學版）, 2009; 29(6): 689692.
38. Curley PJ. Endotoxin, cellular immune dysfunction and acute pancreatitis [J]. Ann R Coll Surg Engl, 1996; 78(6): 531535.
39. Curley P, Nestor M, Collins K, et al. Decreased interleukin2 production in murine acute pancreatitis: potential for immunomodulation [J]. Gastroenterology, 1996; 110(2): 583588.
40. Ma T, Kang C, Shao H, et al. Protective effects of ulinastatin on proliferation and cytokine release of splenocytes from rats with severe acute pancreatitis [J]. Eur Surg Res, 2006; 38(5): 445450.
41. Ryz NR, Meddings JB, Taylor CG. Longchain inulin increases dendritic cells in the Peyer’s patches and increases ex vivo cytokine secretion in the spleen and mesenteric lymph nodes of growing female rats, independent of zinc status [J]. Br J Nutr, 2009; 101(11): 16531663.
42. 王基, 閆軍. 外源性瘦素在大鼠急性胰腺炎中的保護作用 [J]. 山西醫藥雜志, 2007; 36(3): 215217.
43. Kilciler G, Musabak U, Bagci S, et al. Do the changes in the serum levels of IL2, IL4, TNFα, and IL6 reflect the inflammatory activity in the patients with postERCP pancreatitis? [J]. Clin Dev Immunol, 2008; 2008: 481560. doi: 10.1155/2008/481560.
44. Chen CC, Wang SS, Lu RH, et al. Serum interleukin 10 and interleukin 11 in patients with acute pancreatitis [J]. Gut, 1999; 45(6): 895899.
45. Shimizu T, Shiratori K, Sawada T, et al. Recombinant human interleukin11 decreases severity of acute necrotizing pancreatitis in mice [J]. Pancreas, 2000; 21(2): 134140.
46. Bone RC. Sir Isaac Newton, sepsis, SIRS, and CARS [J]. Crit Care Med, 1996; 24(7): 11251128.
47. 熊建平, 文軍. 急性胰腺炎中全身炎癥反應綜合征與抗炎癥反應綜合征 [J]. 國際外科學雜志, 2008; 35(9): 628630.
48. 姚欣敏, 劉牧, 李云濤, 等. 早期反復間斷血濾治療重癥急性胰腺炎的臨床研究 [J]. 中國普外基礎與臨床雜志, 2008; 15(5): 352357.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of Tumor Necrosis Factor-α and Interleukin in Acute Pancreatitis

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