Role of Related Cytokines in Severe Acute Pancreatitis Associated Lung Injury_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Qizhi ¹ , WU Xinmin ² , GUO Yamin ²

min2. 1.Medical College of Qinghai University, Xining 810001, Qinghai Province, China;;
2.Department of General Surgery, People’s Hospital of Qinghai Province, Xining 810007, Qinghai Province, China;

Corresponding?author：

Keywords：

Severe acute pancreatitis; Lung injury; Cytokines

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ObjectiveTo summarize the changes and interaction of the cytokine in severe acute pancreatitis associated lung injury. MethodsThe published literatures at domestic and aboard in recent years about severe acute pancreatitis associated lung injury were collected and reviewed. ResultsThe cytokines had a chain effect, and influenced each other when severe acute pancreatitis with lung injury attacked. ConclusionsRelated cytokines play important roles in severe acute pancreatitis associated lung injury. Researching the related cytokines will contribute to the diagnosis and treatment for severe acute pancreatitis with lung injury.

Citation： LI Qizhi ,WU Xinmin,GUO Yamin. Role of Related Cytokines in Severe Acute Pancreatitis Associated Lung Injury. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(3): 258-260. doi: Copy

1.	Marsboom G, Janssens S. Endothelial progenitor cells: new perspectives and applications in cardiovascular therapies [J]. Expert Rev Cardiovasc Ther, 2008, 6(5): 687701.
2.	Leme AS, Lichtenstein A, ArantesCosta FM, et al. Acute lung injury in experimental pancreatitis in rats: pulmonary protective effects of crotapotin and Nacetylcysteine [J]. Shock, 2002, 18(5): 428433.
3.	Flaishon R, Szold O, Weinbroum AA. Acute lung injury following pancreas ischaemiareperfusion: role of xanthine oxidase [J]. Eur J Clin Invest, 2006, 36(11): 831837.
4.	陸海華, 史忠, 劉波, 等. 急性胰腺炎相關性肺損傷早期血清TNFα、IL1、IL6的變化及其臨床意義 [J]. 重慶醫學, 2007, 36(18): 18181819.
5.	Inagaki T, Hoshino M, Hayakawa T, et al. Interleukin6 is a useful marker for early prediction of the severity of acute pancreatitis [J]. Pancreas, 1997, 14(1): 18.
6.	Stimac D, Fisic＇ E, Milic＇ S, et al. Prognostic values of IL6, IL8, and IL10 in acute pancreatitis [J]. J Clin Gastroenterol, 2006, 40(3): 209212.
7.	Yu JH, Lim JW, Namkung W, et al. Suppression of ceruleininduced cytokine expression by antioxidants in pancreatic acinar cells [J]. Lab Invest, 2002, 82(10): 13591368.
8.	Hattar K, Fink L, Fietzner K, et al. Cell density regulates neutrophil IL8 synthesis: role of IL1 receptor antagonist and soluble TNF receptors [J]. J Immunol, 2001, 166(10): 62876293.
9.	Pastor CM, Matthay MA, Frossard JL. Pancreatitisassociated acute lung injury: new insights [J]. Chest, 2003, 124(6): 23412351.
10.	周粼，梁道明，陳嘉勇，等. 依達拉奉對大鼠重癥急性胰腺炎肺損傷的影響 [J]. 中國普外基礎與臨床雜志, 2010, 17(2): 125154.
11.	Altavilla D, Famulari C, Passaniti M, et al. Lipid peroxidation inhibition reduces NFκB activation and attenuates ceruleininduced pancreatitis [J]. Free Radic Res, 2003, 37(4): 425435.
12.	Mirshafiey A, Mohsenzadegan M. The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis [J]. Iran J Allergy Asthma Immunol, 2008, 7(4): 195202.
13.	Malleo G, Mazzon E, Siriwardena AK, et al. TNFá as a therapeutic target in acute pancreatitis－lessons from experimental models [J]. Scientific World Journal, 2007, 7: 431448.
14.	Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NFkappa B [J]. Annu Rev Cell Biol, 1994, 10: 405455.
15.	Jaffray C, Yang J, Carter G, et al. Pancreatic elastase activates pulmonary nuclear factor kappa B and inhibitory kappa B, mimicking pancreatitisassociated adult respiratory distress syndrome [J]. Surgery, 2000, 128(2): 225231.
16.	莫堅, 劉欣, 何海燕, 等. 倍他米松對大鼠重癥急性胰腺炎肺損傷NFκB、 ICAM1及IL6的影響 [J]. 湖北民族學院學報(醫學版), 2005, 22(4): 1416.
17.	Slavin J, Ghaneh P, Sutton R, et al. Management of necrotizing pancreatitis [J]. World J Gastroenterol, 2001, 7(4): 476481.
18.	張喜平, 吳迪炯. 細胞黏附分子在重癥急性胰腺炎并發急性肺損傷中的作用 [J]. 醫學研究雜志, 2008, 37(8): 112114.
19.	Schmidt J, Rattner DW, Lewandrowski K, et al. A better model of acute pancreatitis for evaluating therapy [J]. Ann Surg, 1992, 215(1): 4456.
20.	Zhao X, Dib M, Wang X, et al. Influence of mast cells on the expression of adhesion molecules on circulating and migrating leukocytes in acute pancreatitisassociated lung injury [J]. Lung, 2005, 183(4): 253264．.
21.	Cunningham C, Sanderson DJ. Malaise in the water maze: untangling the effects of LPS and IL1β on learning and memory [J]. Brain Behav Immun, 2008, 22(8): 11171127.
22.	楊學良, 王廣義. 重癥急性胰腺炎肺損傷大鼠ICAM1和LFA1變化及丹參注射液的干預作用 [J]. 中國老年學雜志, 2010, 30(8): 11081110.
23.	殷濤, 王衛星, 余佳, 等. ICAM1在大鼠急性胰腺炎肺損傷中的作用 [J]. 中國藥師, 2009, 12(5): 551553.
24.	汪良芝, 沈云志．ICAM1表達在大鼠重癥急性胰腺炎肺損傷中的作用 [J]. 胰腺病學, 2005, 5(1): 4042．.
25.	鮑世韻, 伍天崇, 郭躍華, 等. ICAM1高表達在大鼠重癥急性胰腺炎早期急性肺損傷中的作用 [J]. 廣東醫學, 2010, 31(4): 418421.
26.	Granger J, Remick D. Acute pancreatitis: models, markers, and mediators [J]. Shock, 2005, 24 Suppl 1: 4551.
27.	姜戰武, 李厚祥, 邵蘇吉. 血清PLA2對急性胰腺炎的診斷和預后判斷價值 [J]. 南通醫學院學報, 1996, 16(3): 326327.
28.	Strieter RM, Lynch JP 3rd, Basha MA, et al. Host responses in mediating sepsis and adult respiratory distress syndrom [J]. Semin Respir Infect, 1990, 5(3): 233247.
29.	Ohtsuki M, Taketomi Y, Arata S, et al. Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction [J]. J Biol Chem, 2006, 281(47): 3642036433.
30.	Rongione AJ, Kusske AM, Kwan K, et al. Interleukin 10 reduces the severity of acute pancreatitis in rats [J]. Gastroenterology, 1997, 112(3): 960967.
31.	Van Laethem JL, Marchant A, Delvaux A, et al. Interleukin 10 prevents necrosis in murine experimental acute pancreatitis [J]. Gastroenterology, 1995, 108(6): 19171922.
32.	付林, 程書榜, 高海斌, 等. IL10區域動脈灌注減輕急性胰腺炎大鼠肺損傷的實驗研究 [J]. 中國普通外科雜志, 2006, 15(8): 619621.
33.	Kaufmann P, Tilz GP, Lueger A, et al. Elevated plasma levels of soluble tumor necrosis factor receptor (sTNFRp60) reflect severity of acute pancreatitis [J]. Intensive Care Med,1997, 23(8): 841848.
34.	Keck T, Balcom JH 4th, Fernándezdel Castillo C, et al. Matrix metalloproteinase9 promotes neutrophil migration and alveolar capillary leakage in pancreatitisassociated lung injury in the rat [J]. Gastroenterology, 2002, 122(1): 188201.

1. Marsboom G, Janssens S. Endothelial progenitor cells: new perspectives and applications in cardiovascular therapies [J]. Expert Rev Cardiovasc Ther, 2008, 6(5): 687701.
2. Leme AS, Lichtenstein A, ArantesCosta FM, et al. Acute lung injury in experimental pancreatitis in rats: pulmonary protective effects of crotapotin and Nacetylcysteine [J]. Shock, 2002, 18(5): 428433.
3. Flaishon R, Szold O, Weinbroum AA. Acute lung injury following pancreas ischaemiareperfusion: role of xanthine oxidase [J]. Eur J Clin Invest, 2006, 36(11): 831837.
4. 陸海華, 史忠, 劉波, 等. 急性胰腺炎相關性肺損傷早期血清TNFα、IL1、IL6的變化及其臨床意義 [J]. 重慶醫學, 2007, 36(18): 18181819.
5. Inagaki T, Hoshino M, Hayakawa T, et al. Interleukin6 is a useful marker for early prediction of the severity of acute pancreatitis [J]. Pancreas, 1997, 14(1): 18.
6. Stimac D, Fisic＇ E, Milic＇ S, et al. Prognostic values of IL6, IL8, and IL10 in acute pancreatitis [J]. J Clin Gastroenterol, 2006, 40(3): 209212.
7. Yu JH, Lim JW, Namkung W, et al. Suppression of ceruleininduced cytokine expression by antioxidants in pancreatic acinar cells [J]. Lab Invest, 2002, 82(10): 13591368.
8. Hattar K, Fink L, Fietzner K, et al. Cell density regulates neutrophil IL8 synthesis: role of IL1 receptor antagonist and soluble TNF receptors [J]. J Immunol, 2001, 166(10): 62876293.
9. Pastor CM, Matthay MA, Frossard JL. Pancreatitisassociated acute lung injury: new insights [J]. Chest, 2003, 124(6): 23412351.
10. 周粼，梁道明，陳嘉勇，等. 依達拉奉對大鼠重癥急性胰腺炎肺損傷的影響 [J]. 中國普外基礎與臨床雜志, 2010, 17(2): 125154.
11. Altavilla D, Famulari C, Passaniti M, et al. Lipid peroxidation inhibition reduces NFκB activation and attenuates ceruleininduced pancreatitis [J]. Free Radic Res, 2003, 37(4): 425435.
12. Mirshafiey A, Mohsenzadegan M. The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis [J]. Iran J Allergy Asthma Immunol, 2008, 7(4): 195202.
13. Malleo G, Mazzon E, Siriwardena AK, et al. TNFá as a therapeutic target in acute pancreatitis－lessons from experimental models [J]. Scientific World Journal, 2007, 7: 431448.
14. Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NFkappa B [J]. Annu Rev Cell Biol, 1994, 10: 405455.
15. Jaffray C, Yang J, Carter G, et al. Pancreatic elastase activates pulmonary nuclear factor kappa B and inhibitory kappa B, mimicking pancreatitisassociated adult respiratory distress syndrome [J]. Surgery, 2000, 128(2): 225231.
16. 莫堅, 劉欣, 何海燕, 等. 倍他米松對大鼠重癥急性胰腺炎肺損傷NFκB、 ICAM1及IL6的影響 [J]. 湖北民族學院學報(醫學版), 2005, 22(4): 1416.
17. Slavin J, Ghaneh P, Sutton R, et al. Management of necrotizing pancreatitis [J]. World J Gastroenterol, 2001, 7(4): 476481.
18. 張喜平, 吳迪炯. 細胞黏附分子在重癥急性胰腺炎并發急性肺損傷中的作用 [J]. 醫學研究雜志, 2008, 37(8): 112114.
19. Schmidt J, Rattner DW, Lewandrowski K, et al. A better model of acute pancreatitis for evaluating therapy [J]. Ann Surg, 1992, 215(1): 4456.
20. Zhao X, Dib M, Wang X, et al. Influence of mast cells on the expression of adhesion molecules on circulating and migrating leukocytes in acute pancreatitisassociated lung injury [J]. Lung, 2005, 183(4): 253264．.
21. Cunningham C, Sanderson DJ. Malaise in the water maze: untangling the effects of LPS and IL1β on learning and memory [J]. Brain Behav Immun, 2008, 22(8): 11171127.
22. 楊學良, 王廣義. 重癥急性胰腺炎肺損傷大鼠ICAM1和LFA1變化及丹參注射液的干預作用 [J]. 中國老年學雜志, 2010, 30(8): 11081110.
23. 殷濤, 王衛星, 余佳, 等. ICAM1在大鼠急性胰腺炎肺損傷中的作用 [J]. 中國藥師, 2009, 12(5): 551553.
24. 汪良芝, 沈云志．ICAM1表達在大鼠重癥急性胰腺炎肺損傷中的作用 [J]. 胰腺病學, 2005, 5(1): 4042．.
25. 鮑世韻, 伍天崇, 郭躍華, 等. ICAM1高表達在大鼠重癥急性胰腺炎早期急性肺損傷中的作用 [J]. 廣東醫學, 2010, 31(4): 418421.
26. Granger J, Remick D. Acute pancreatitis: models, markers, and mediators [J]. Shock, 2005, 24 Suppl 1: 4551.
27. 姜戰武, 李厚祥, 邵蘇吉. 血清PLA2對急性胰腺炎的診斷和預后判斷價值 [J]. 南通醫學院學報, 1996, 16(3): 326327.
28. Strieter RM, Lynch JP 3rd, Basha MA, et al. Host responses in mediating sepsis and adult respiratory distress syndrom [J]. Semin Respir Infect, 1990, 5(3): 233247.
29. Ohtsuki M, Taketomi Y, Arata S, et al. Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction [J]. J Biol Chem, 2006, 281(47): 3642036433.
30. Rongione AJ, Kusske AM, Kwan K, et al. Interleukin 10 reduces the severity of acute pancreatitis in rats [J]. Gastroenterology, 1997, 112(3): 960967.
31. Van Laethem JL, Marchant A, Delvaux A, et al. Interleukin 10 prevents necrosis in murine experimental acute pancreatitis [J]. Gastroenterology, 1995, 108(6): 19171922.
32. 付林, 程書榜, 高海斌, 等. IL10區域動脈灌注減輕急性胰腺炎大鼠肺損傷的實驗研究 [J]. 中國普通外科雜志, 2006, 15(8): 619621.
33. Kaufmann P, Tilz GP, Lueger A, et al. Elevated plasma levels of soluble tumor necrosis factor receptor (sTNFRp60) reflect severity of acute pancreatitis [J]. Intensive Care Med,1997, 23(8): 841848.
34. Keck T, Balcom JH 4th, Fernándezdel Castillo C, et al. Matrix metalloproteinase9 promotes neutrophil migration and alveolar capillary leakage in pancreatitisassociated lung injury in the rat [J]. Gastroenterology, 2002, 122(1): 188201.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Role of Related Cytokines in Severe Acute Pancreatitis Associated Lung Injury

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