Characteristics of Diagnosis and Treatment for Rectal Cancer in The Young Patients_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

A Ruhan ^1,2 , WANG Xiaodong ¹ , LI Li. ¹

1. Department of Anal-Colorectal Surgery, West China Hospital, Sichuan University, Chengdu 610041,Sichuan Province, China;;
2. West China Medical School/West China Hospital MCQ Team, Sichuan University, Chengdu 610041, Sichuan Province, China;

Corresponding?author：

Keywords：

Young patient; Rectal cancer; Epidemiology; Diagnosis; Treatment

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Objective 　To explore the characteristics of diagnosis and treatment for the rectal cancer in the young patients （≤40 years）．
Methods 　The domestic and abroad literatures about the research on the progress of rectal cancer in the young patients were reviewed, the clinical data of patients with rectal cancer were compared between the young patients and the other age patients, the characteristics of diagnosis and treatment for the rectal cancer in the young patients were summarized．
Results 　The onsets of the young patients with rectal cancer were related to the diet，lifestyle, and genetic factors．Compared with the older patients, more later stage, higher percentage of poor differentiation, earlier lymph node metastasis were found in the young patients with rectal cancer．Rectal cancer of the young patients was often misdiagnosed and with a poor prognosis．Currently，surgery assisted with neoadjuvant therapy was generally acknowledged as a better method．
Conclusions 　It has specificity in epidemiology, pathology, treatment, prognosis, and so on for rectal cancer in the young patients, but surgery needs further research．

Citation： A Ruhan,WANG Xiaodong,LI Li.. Characteristics of Diagnosis and Treatment for Rectal Cancer in The Young Patients. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(2): 228-231. doi: Copy

1.	董秋美, 鄭偉華, 何友兼．老年結直腸癌與中青年結直腸癌臨床病理特征對比分析 [J]．南方醫科大學學報, 2010, 30(9)：2128-2130．.
2.	O’Connell JB, Maggard MA, Livingston EH, et al．Colorectal cancer in the young [J]．Am J Surg, 2004, 187(3)：343-348．.
3.	李清晨, 代文杰, 許軍．青年期結直腸癌的臨床特點及誤診分析 [J]．消化外科, 2006, 5(5)：377-379．.
4.	盧煥全, 周志偉, 萬德森, 等．青年人結直腸癌283 例臨床病理特征及預后分析 [J]．廣東醫學, 2008, 29(2)：265-267．.
5.	O’connell JB, Maggard MA, Liu JH, et al．Rates of colon and rectal cancers are increasing in young adults [J]．Am Surg, 2003,69(10)：866-872．.
6.	萬德森．結直腸癌流行病學與預防 [J]．中國中西醫結合外科雜志, 2011, 17(1)：3-7．.
7.	Stewart BW, Kleihues P．World Cancer Report [M]．Lyon：IARC press, 2003：198．.
8.	American Cancer Society．Global Cancer Facts & Figures [M]．Atlanta, GA：American Cancer Society, 2007：12．.
9.	張振亞, 趙澤貞．大腸癌流行病學研究現狀及展望 [J]．腫瘤防治研究, 2000, 27(2)：154-156．.
10.	Paganell GM．Vitmin and cancer [J]．Cancer, 1992, 8：47．.
11.	李士芬．護理干預對中青年高血壓病患者遵醫行為的影響 [J].中外醫學研究, 2010, 8(28)：108．.
12.	張翼耀, 曹葦, 過兆基, 等．青年直腸癌臨床病理特征及誤診原因分析 [J]．臨床腫瘤學雜志, 2007, 12(3)：218-220．.
13.	Burt RW．Familial risk and colorectal cancer [J]．Int J Cancer,1996, 25(4)：793-803．.
14.	Wilmink A．Overview of the epidemiology of colorectal cancer [J]．Dis Colon Rectum, 1997, 40(4)：483-493．.
15.	Boland CR, Thibodeau SN, Hamilton SR, et al．A National Cancer institute workshop on microsatellite instability for cancer detection and familial predisposition：development ofinternational criteria for the determination of microsatellite instability in colorectal cancer [J]．Cancer Res, 1998, 58(22)：5248-5257．.
16.	于志堅．結直腸癌肝轉移的現代治療 [J]．南通大學學報( 醫學版), 2010, 30(2)：132-135．.
17.	Parkin DM, Bray F, Ferlay J, et al．Global cancer statistics,2002 [J]．CA Cancer J Clin, 2005, 55(2)：74-108．.
18.	姚建根, 毛躍, 焦蘭龍, 等．青年人結直腸癌38 例臨床分析 [J].現代腫瘤醫學, 2008, 16(1)：89-90．.
19.	黃明德．37 例青年人結腸直腸癌臨床分析 [J]．亞太傳統醫藥,2010, 6(5)：94-95．.
20.	保紅平, 方登華, 高瑞崗, 等．青年人結直腸癌臨床病理分析[J]．中國普外基礎與臨床雜志, 2004, 11(1)：52-54．.
21.	朱軍, 王劍, 羅吉．青年期大腸癌臨床分析 [J]．消化外科,2003, 2(6)：419-420．.
22.	Durno C, Aronson M, Bapat B, et al．Family history and molecular features of children, adolescents, and young adults with colorectal carcinoma [J]．Gut, 2005, 54(8)：1146-1150．.
23.	Wong P, Verselis SJ, Garber JE, et al．Prevalence of early onset colorectal cancer in 397 patients with classic Li-Fraumeni syndrome [J]．Gastroenterology, 2006, 130(1)：73-79．.
24.	張亞歷, 聶軍, 周杰, 等．中國青年大腸癌的發病特點及地理分布 [J]．中華消化內鏡雜志, 1997, 14(1)：12-15．.
25.	楊福祥, 姜南．青年大腸癌48 例臨床分析 [J]．實用醫學雜志, 2007, 23(9)：1373-1374．.
26.	賈興芳, 劉成霞．青年人結直腸癌101 例臨床病理特征分析[J]．濱州醫學院學報, 2008, 31(6)：426-428．.
27.	賴金火, 周永建, 盧輝山, 等．青年人直腸癌肝轉移高危因素分析 [J]．中國醫師進修雜志, 2009, 32(20)：13-16．.
28.	Endreseth BH, Romundstad P, Myrvold HE, et al．Rectal cancer in the young patient [J]．Dis Colon Rectum, 2006, 49(7)：993-1001．.
29.	謝正勇, 卿三華．國人青年結直腸癌解剖部位分布及臨床病理特點 [J]．世界華人消化雜志, 2003, 11(10)： 1511-1514．.
30.	李立, 汪曉東, 舒曄, 等．四川大學華西醫院? 結直腸癌手術治療指南( 一) [J]．中國普外基礎與臨床雜志, 2008, 15(10)：778．.
31.	宏志, 張傳珉, 張涌泉, 等．青年人結直腸癌71 例臨床分析[J]．結直腸肛門外科, 2009, 15(6)：398-402．.
32.	汪曉東, 曹霖, 曾天芳, 等．多學科協作診治模式下新輔助/輔助化療聯合結直腸癌手術的臨床效果 [J]．中國普外基礎與臨床雜志, 2008, 15(8)：615-619．.
33.	汪曉東, 劉春娟, 陳增蓉, 等．多學科協作診治模式下新輔助化療聯合手術治療結直腸癌患者的生存質量評估 [J]．中國普外基礎與臨床雜志, 2008, 15(5）：371-374．.
34.	郁寶銘, 吳唯勤．新輔助化放療與TME 聯合治療局部進展期低位直腸癌 [J]．中國實用外科雜志, 2005, 25(5)：270-272．.
35.	Crane CH, Skibber JM, Feig BW, et al．Response to preoperative chemoradiation increases the use of sphincter-preserving surgery in patients with locally advanced low rectal carcinoma [J]．Cancer, 2003, 97(2)：517-524．.
36.	Bosset JF, Calais G, Daban A, et al；EORTC Radiotherapy Group. Preoperative chemoradiotherapy versus preoperative radiotherapy in rectal cancer patients：assessment of acute toxicity and treatment compliance．Report of the 22 921 randomised trial conducted by the EORTC Radiotherapy Group [J]．Eur J Cancer, 2004,40(2)：219-224．.
37.	Levin KE, Dozois RR．Epidemiology of large bowel cancer [J]．World J Surg, 1991, 15(5)：562-567．.
38.	陳峻青．重視大腸癌復發、轉移的臨床研究 [J]．中國實用外科雜志, 2002, 22(6)：321．.

1. 董秋美, 鄭偉華, 何友兼．老年結直腸癌與中青年結直腸癌臨床病理特征對比分析 [J]．南方醫科大學學報, 2010, 30(9)：2128-2130．.
2. O’Connell JB, Maggard MA, Livingston EH, et al．Colorectal cancer in the young [J]．Am J Surg, 2004, 187(3)：343-348．.
3. 李清晨, 代文杰, 許軍．青年期結直腸癌的臨床特點及誤診分析 [J]．消化外科, 2006, 5(5)：377-379．.
4. 盧煥全, 周志偉, 萬德森, 等．青年人結直腸癌283 例臨床病理特征及預后分析 [J]．廣東醫學, 2008, 29(2)：265-267．.
5. O’connell JB, Maggard MA, Liu JH, et al．Rates of colon and rectal cancers are increasing in young adults [J]．Am Surg, 2003,69(10)：866-872．.
6. 萬德森．結直腸癌流行病學與預防 [J]．中國中西醫結合外科雜志, 2011, 17(1)：3-7．.
7. Stewart BW, Kleihues P．World Cancer Report [M]．Lyon：IARC press, 2003：198．.
8. American Cancer Society．Global Cancer Facts & Figures [M]．Atlanta, GA：American Cancer Society, 2007：12．.
9. 張振亞, 趙澤貞．大腸癌流行病學研究現狀及展望 [J]．腫瘤防治研究, 2000, 27(2)：154-156．.
10. Paganell GM．Vitmin and cancer [J]．Cancer, 1992, 8：47．.
11. 李士芬．護理干預對中青年高血壓病患者遵醫行為的影響 [J].中外醫學研究, 2010, 8(28)：108．.
12. 張翼耀, 曹葦, 過兆基, 等．青年直腸癌臨床病理特征及誤診原因分析 [J]．臨床腫瘤學雜志, 2007, 12(3)：218-220．.
13. Burt RW．Familial risk and colorectal cancer [J]．Int J Cancer,1996, 25(4)：793-803．.
14. Wilmink A．Overview of the epidemiology of colorectal cancer [J]．Dis Colon Rectum, 1997, 40(4)：483-493．.
15. Boland CR, Thibodeau SN, Hamilton SR, et al．A National Cancer institute workshop on microsatellite instability for cancer detection and familial predisposition：development ofinternational criteria for the determination of microsatellite instability in colorectal cancer [J]．Cancer Res, 1998, 58(22)：5248-5257．.
16. 于志堅．結直腸癌肝轉移的現代治療 [J]．南通大學學報( 醫學版), 2010, 30(2)：132-135．.
17. Parkin DM, Bray F, Ferlay J, et al．Global cancer statistics,2002 [J]．CA Cancer J Clin, 2005, 55(2)：74-108．.
18. 姚建根, 毛躍, 焦蘭龍, 等．青年人結直腸癌38 例臨床分析 [J].現代腫瘤醫學, 2008, 16(1)：89-90．.
19. 黃明德．37 例青年人結腸直腸癌臨床分析 [J]．亞太傳統醫藥,2010, 6(5)：94-95．.
20. 保紅平, 方登華, 高瑞崗, 等．青年人結直腸癌臨床病理分析[J]．中國普外基礎與臨床雜志, 2004, 11(1)：52-54．.
21. 朱軍, 王劍, 羅吉．青年期大腸癌臨床分析 [J]．消化外科,2003, 2(6)：419-420．.
22. Durno C, Aronson M, Bapat B, et al．Family history and molecular features of children, adolescents, and young adults with colorectal carcinoma [J]．Gut, 2005, 54(8)：1146-1150．.
23. Wong P, Verselis SJ, Garber JE, et al．Prevalence of early onset colorectal cancer in 397 patients with classic Li-Fraumeni syndrome [J]．Gastroenterology, 2006, 130(1)：73-79．.
24. 張亞歷, 聶軍, 周杰, 等．中國青年大腸癌的發病特點及地理分布 [J]．中華消化內鏡雜志, 1997, 14(1)：12-15．.
25. 楊福祥, 姜南．青年大腸癌48 例臨床分析 [J]．實用醫學雜志, 2007, 23(9)：1373-1374．.
26. 賈興芳, 劉成霞．青年人結直腸癌101 例臨床病理特征分析[J]．濱州醫學院學報, 2008, 31(6)：426-428．.
27. 賴金火, 周永建, 盧輝山, 等．青年人直腸癌肝轉移高危因素分析 [J]．中國醫師進修雜志, 2009, 32(20)：13-16．.
28. Endreseth BH, Romundstad P, Myrvold HE, et al．Rectal cancer in the young patient [J]．Dis Colon Rectum, 2006, 49(7)：993-1001．.
29. 謝正勇, 卿三華．國人青年結直腸癌解剖部位分布及臨床病理特點 [J]．世界華人消化雜志, 2003, 11(10)： 1511-1514．.
30. 李立, 汪曉東, 舒曄, 等．四川大學華西醫院? 結直腸癌手術治療指南( 一) [J]．中國普外基礎與臨床雜志, 2008, 15(10)：778．.
31. 宏志, 張傳珉, 張涌泉, 等．青年人結直腸癌71 例臨床分析[J]．結直腸肛門外科, 2009, 15(6)：398-402．.
32. 汪曉東, 曹霖, 曾天芳, 等．多學科協作診治模式下新輔助/輔助化療聯合結直腸癌手術的臨床效果 [J]．中國普外基礎與臨床雜志, 2008, 15(8)：615-619．.
33. 汪曉東, 劉春娟, 陳增蓉, 等．多學科協作診治模式下新輔助化療聯合手術治療結直腸癌患者的生存質量評估 [J]．中國普外基礎與臨床雜志, 2008, 15(5）：371-374．.
34. 郁寶銘, 吳唯勤．新輔助化放療與TME 聯合治療局部進展期低位直腸癌 [J]．中國實用外科雜志, 2005, 25(5)：270-272．.
35. Crane CH, Skibber JM, Feig BW, et al．Response to preoperative chemoradiation increases the use of sphincter-preserving surgery in patients with locally advanced low rectal carcinoma [J]．Cancer, 2003, 97(2)：517-524．.
36. Bosset JF, Calais G, Daban A, et al；EORTC Radiotherapy Group. Preoperative chemoradiotherapy versus preoperative radiotherapy in rectal cancer patients：assessment of acute toxicity and treatment compliance．Report of the 22 921 randomised trial conducted by the EORTC Radiotherapy Group [J]．Eur J Cancer, 2004,40(2)：219-224．.
37. Levin KE, Dozois RR．Epidemiology of large bowel cancer [J]．World J Surg, 1991, 15(5)：562-567．.
38. 陳峻青．重視大腸癌復發、轉移的臨床研究 [J]．中國實用外科雜志, 2002, 22(6)：321．.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Characteristics of Diagnosis and Treatment for Rectal Cancer in The Young Patients

Abstract Full text Figures/Tables Video References Cited by

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