摘要:目的:評價孟魯司特用于過敏性鼻炎的臨床療效和安全性。方法:計算機檢索PubMed、維普及CNKI數據庫,手工收集有關孟魯司特用于過敏性鼻炎治療的臨床研究,根據納入和剔除標準匯集文獻,采用Jadad量表進行納入文獻質量評價,對總體治療有效性使用Revman4.2軟件進行Meta分析。結果:療效評價共納入9個臨床隨機對照研究共650例。有效率孟魯司特組高于對照組,異質性檢驗顯示各亞組及其合并總有效率P值均大于0.1,I2 lt;50%,采用固定效應模型計算。2周時孟魯司特組和對照組無統計學差異(P gt;0.1),但2月、3月時二組均有顯著性統計學差異(P lt;0.000 01),三個亞組綜合分析孟魯司特組和對照組有顯著性統計學差異(P lt;0.000 01),不良反應差異無統計學意義。結論:現有臨床證據顯示孟魯司特較傳統抗過敏藥物對過敏性鼻炎的治療有效,但由于納入研究存在選擇性偏倚和測量性偏倚的可能性,勢必影響結果的論證強度。故期待更多高質量的隨機雙盲對照試驗性研究,以提供更高質量的證據。
Abstract: Objective: To evaluate montelukast for allergic rhinitis clinical efficacy and safety. Methods: We searched the PubMed,VIP and CNKI databases, manual collection of clinical study about allergic rhinitis treatment of montelukast, based on inclusion and exclusion criteria for pooling of literature, Jadad scale used for quality assessment of the literature. Then use Revman4.2 Meta analysis software to evaluate the overall effectiveness. Results: Nine RCT clinical study have been included, The results showed that montelukast group was higher than control group on efficient control, Heterogeneity test showed that the subgroup and its total effective rate is P gt;01,I2 lt;50%. Therefore, we adopted a fixed effects model. After 2 weeks montelukast group and the control group no significant difference (P gt;0.1). But after 2,3 month the two groups were statistically significant differences(P lt;0.000 01). On a comprehensive analysis of the three subgroups, montelukast group and the control group statistically significant differences(P lt;0.000 01), adverse drug reactions was no significant difference. Conclusion: The available clinical evidence to show that montelukast for the treatment of allergic rhinitis and effective, However, due to the existence of selection and measurement bias, This may affect the outcome of the argument strength.Therefore look forward to more highquality randomized and doubleblind controlled trials to provide highquality evidence.

Citation： CHEN Wei,HE Lina,LIANG Nan,et al.. A MetaAnalysis of Montelukast Treatment of Allergic Rhinitis. West China Medical Journal, 2009, 24(11): 2926-2929. doi: Copy

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