Effects of Remifentanly and Ketamin on Parturient Blood Pressure, Heart Rate and Neonate Apgar Score_West China Medical Journal

Authors：

HE Juying ¹ , CAO Rong ¹ , LI Shouli ¹ , et al ²

1the Department of Anesthesiology, Maternal and Children’s Health Care Hospital of Chengdu, Chengdu 610031; 2the Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding?author：

Keywords：

全身麻醉; 剖宮產; 瑞芬太尼; 氯胺酮; Apgar評分

Video：

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目的:對照研究在全麻剖宮產術中應用瑞芬太尼和氯胺酮誘導對母嬰的影響。方法:選擇100例禁忌椎管內麻醉而須行全麻剖宮產手術的患者,分為兩組,氯胺酮組靜注異丙酚1.5mg/kg+氯胺酮1mg／kg+琥珀膽堿1.5mg／kg;瑞芬太尼組靜注異丙酚1.5mg/kg+瑞芬太尼1μg/kg+琥珀膽堿1.5mg／kg誘導插管,胎兒娩出后均靜注芬太尼2g／kg、泵注異丙酚3mg/(kg·h)和吸入異氟醚0.5MAC維持麻醉,阿曲庫銨維持肌松。結果:瑞芬太尼組插管(切皮)后血壓、心率升高幅度顯著小于氯胺酮組,兩組新生兒1min、5min Apgar評分無明顯差異。結論:瑞芬太尼用于產科全麻優于氯胺酮,安全可行。

Citation： HE Juying,CAO Rong,LI Shouli,et al. Effects of Remifentanly and Ketamin on Parturient Blood Pressure, Heart Rate and Neonate Apgar Score. West China Medical Journal, 2009, 24(8): 2114-2116. doi: Copy

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1. GLASS P S, GAN T J, HOWELL S. A review of tphamarmacodynamics of remifentanil[J]． Anesth Analg,1999,89:7-14.
2. 吳新民,葉鐵虎,岳云,等.國產注射用鹽酸瑞芬太尼有效性和安全性的評價[J].中華麻醉學雜志,2003,23(4):245-２４8.
3. 敖光亮,黃盛輝.小劑量氯胺酮防止剖宮產術中腹膜牽拉反應的臨床觀察[J].廣東醫學,1999,20(6):56-57.
4. 莊心良,曾因明,陳伯鑾,主編.現代麻醉學[M]．第3版.北京:人民衛生出版社,2003:525.
5. 高秀江,張志輝,毛瑞芬,等.瑞芬太尼與芬太尼對腹部手術患者全麻誘導期血液動力學的影響[J].中華麻醉學雜志,2005,25(2):149-50.
6. 黃悅,杭燕南.小兒瑞芬太尼藥動學及臨床研究進展[J].國外醫學麻醉與復蘇分冊,2005,26(2):114-117.
7. EGAN T D, LEMMENS H J, FISET P, et al. The pharmacokinetics of the new shortacting opioid remifentanil (GI87084B) in healthy adult male[J]. Anesthesiology,1993,79:881.

West China Medical Journal

Effects of Remifentanly and Ketamin on Parturient Blood Pressure, Heart Rate and Neonate Apgar Score

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