An Analysis of Clinical Characteristics of 46 Women with Ankylosing Spondylitis_West China Medical Journal

Authors：

ZHONG Xue , YANG Min , YANG Nanping.

the Department of Clinical Immunology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding?author：

Keywords：

女性; 強直性脊柱炎; 臨床特點

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目的:探討女性強直性脊柱炎患者的臨床特點。方法:回顧性分析華西醫院風濕免疫科2003年1月1日至2009年1月1日住院收治的女性強直性脊柱炎患者住院病歷共計46例,抽取與女性患者入院時間及病程大致相等的男性病歷40例,記錄發病年齡、病程、首發癥狀、臨床表現、實驗室檢查,并對兩組數據進行比較,調查女性患者中血小板計數與血沉、C-反應蛋白、球蛋白的相互關系。結果:發病年齡女性組為(30±11)歲,男性組為(24±7)歲(P＝0.003);首發癥狀、主要臨床表現、關節活動受限和病情活動指標在兩組無統計學差異(P gt;0.05)。相關分析顯示,血小板計數與C-反應蛋白、血沉、球蛋白分別存在較好的正相關關系(C反應蛋白:r=0.608,P=0.000;血沉:r=0.558,P=0.000;球蛋白r=0.411,P=0.005)。女性組中HLAB27陽性患者與陰性患者的年齡差異無統計學意義(P＞0.05)。結論:女性強直性脊柱患者的發病年齡大于男性,患者的血小板計數有助于評價病情活動。

Citation： ZHONG Xue,YANG Min,YANG Nanping.. An Analysis of Clinical Characteristics of 46 Women with Ankylosing Spondylitis. West China Medical Journal, 2009, 24(8): 2081-2083. doi: Copy

1.	LEE J H, JUN J B, JUNG S, et al. Higher prevalence of peripheral arthritis among ankylosing spondylitis patients[J]. J Korean Med Sci,2002,17(5):669-673.
2.	ROUF J, STUCKI G. Validity aspects of erythrocyte sedimentation rate and Creactive protein in ankylosing spondylitis: a literature review[J]. J Rheumatology,1999,26:966-970.
3.	LUKAS C, LANDEW R, SIEPER J, et al. Development of an ASASendorsed disease activity score (ASDAS) in patients with ankylosing spondylitis[J]. Ann Rheum Dis,2009,68(1):1824.
4.	王俊祥,顧光,陳海英,等.血小板參數與強直性脊柱炎病情活動的相關性研究[J].河北醫藥,2008, 30(4):472-473.
5.	WANG F, YAN C G, XIANG H Y, et al. The significance of platelet activation in ankylosing spondylitis[J]. Clin Rheumatol,2008,27:767-769.
6.	王興茂,朱玉琴,朱桂英,等,強直性脊柱炎并血小板增多癥一例報告[J].中國臨床實驗室,2002,1(2):20.
7.	GRAN J T, HUSBY G. Ankylosing spondylitis in women[J]. Seminars Arthritis Rheum,1991,19 (5):303-312.
8.	LEE W, REVEILLE J D, WEISMAN M H, et al. Women with ankylosing spondylitis: a review[J]. Arthritis Rheum,2008,59(3):449-454.
9.	張劍波,周彬,吳小丹,等.四川地區漢族強直性脊柱炎患者HLAB27抗原陽性頻率和表達強度的聯合觀察[J].四川醫學,2008,29(8):1071-1074.
10.	曾憲國,劉湘源.女性與男性強直性脊柱炎對比研究[J].醫學文選,2001,15(6):132-134.
11.	倪吳花,胡曉霞,章圣輝,等.強直性脊柱炎867例HLAB27的表達及意義[J].實用醫學雜志,2008 24 (9): 1511-1513.
12.	JAAKKOLA E, HERZBERG I, LAIHO K, et al. Finnish HLA studies confirm the increased risk conferred by HLAB27 homozygosity in ankylosing spondylitis[J]. Ann Rheum Dis,2006,65: 775-80.
13.	STENSEN M, FRGER F, NELSON J L, et al. Pregnancy in patients with rheumatic disease: antiinflammatory cytokines increase in pregnancy and decrease post partum[J]. Ann Rheum Dis,2005,64(6):839-844.

1. LEE J H, JUN J B, JUNG S, et al. Higher prevalence of peripheral arthritis among ankylosing spondylitis patients[J]. J Korean Med Sci,2002,17(5):669-673.
2. ROUF J, STUCKI G. Validity aspects of erythrocyte sedimentation rate and Creactive protein in ankylosing spondylitis: a literature review[J]. J Rheumatology,1999,26:966-970.
3. LUKAS C, LANDEW R, SIEPER J, et al. Development of an ASASendorsed disease activity score (ASDAS) in patients with ankylosing spondylitis[J]. Ann Rheum Dis,2009,68(1):1824.
4. 王俊祥,顧光,陳海英,等.血小板參數與強直性脊柱炎病情活動的相關性研究[J].河北醫藥,2008, 30(4):472-473.
5. WANG F, YAN C G, XIANG H Y, et al. The significance of platelet activation in ankylosing spondylitis[J]. Clin Rheumatol,2008,27:767-769.
6. 王興茂,朱玉琴,朱桂英,等,強直性脊柱炎并血小板增多癥一例報告[J].中國臨床實驗室,2002,1(2):20.
7. GRAN J T, HUSBY G. Ankylosing spondylitis in women[J]. Seminars Arthritis Rheum,1991,19 (5):303-312.
8. LEE W, REVEILLE J D, WEISMAN M H, et al. Women with ankylosing spondylitis: a review[J]. Arthritis Rheum,2008,59(3):449-454.
9. 張劍波,周彬,吳小丹,等.四川地區漢族強直性脊柱炎患者HLAB27抗原陽性頻率和表達強度的聯合觀察[J].四川醫學,2008,29(8):1071-1074.
10. 曾憲國,劉湘源.女性與男性強直性脊柱炎對比研究[J].醫學文選,2001,15(6):132-134.
11. 倪吳花,胡曉霞,章圣輝,等.強直性脊柱炎867例HLAB27的表達及意義[J].實用醫學雜志,2008 24 (9): 1511-1513.
12. JAAKKOLA E, HERZBERG I, LAIHO K, et al. Finnish HLA studies confirm the increased risk conferred by HLAB27 homozygosity in ankylosing spondylitis[J]. Ann Rheum Dis,2006,65: 775-80.
13. STENSEN M, FRGER F, NELSON J L, et al. Pregnancy in patients with rheumatic disease: antiinflammatory cytokines increase in pregnancy and decrease post partum[J]. Ann Rheum Dis,2005,64(6):839-844.

West China Medical Journal

An Analysis of Clinical Characteristics of 46 Women with Ankylosing Spondylitis

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