Nocturnal Arrhythmia in Obstructive Sleep ApneaHypopnea Syndrome_West China Medical Journal

Authors：

WANG Yongsheng ¹ , LI Kai ² , LIANG Zongan. ³

1Department of Medicine,363 Hospital of Chengdu, Chengdu Sichuan 610041,China;

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Keywords：

睡眠呼吸暫停; 心律失常; 多導睡眠圖; 動態心電圖

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目的:了解阻塞性睡眠呼吸暫停綜合癥(OSAHS)患者夜間心律失常的發生情況、常見類型及相關因素。方法:對67例睡眠打鼾患者同步進行動態心電圖及多導睡眠圖監測。以呼吸暫停指數及夜間最低氧飽和度將研究對象進行分組,比較分析夜間心律失常發生率及發生類型并進一步分析夜間心律失常的相關因素。結果:OSAS組的夜間心律失常發生率顯著高于單純鼾癥患者。隨著OSAS加重,呼吸暫停低通氣指數逐漸增大,夜間氧飽和度下降越明顯,心律失常發生率升高,發生時間延長、惡性程度增加,尤其以緩慢型心律失常的發生率增多。結論:OSAHS患者夜間心律失常的發生率及嚴重程度與OSAHS嚴重程度呈正相關,夜間心律失常的誘發與呼吸暫停低通氣指數及低氧血癥密切相關。應重視夜間心律失常患者合并存在的OSAHS的診治。

Citation： WANG Yongsheng,LI Kai,LIANG Zongan.. Nocturnal Arrhythmia in Obstructive Sleep ApneaHypopnea Syndrome. West China Medical Journal, 2009, 24(8): 2020-2022. doi: Copy

1.	中華醫學會呼吸病學分會睡眠呼吸疾病學組.阻塞性睡眠呼吸暫停低通氣綜合征診治指南(草案)[J].中華結核和呼吸雜志,2002, 25:195-198.
2.	HOFFSTEIN V, MATEI KA S. Cardiac arrhythmias, Snoring and sleep apnea[J]. Chest,1994, 106: 446.
3.	ALONSOFERNANDEZ A, GARCIARIO F, RRCIONERO M A, et al. Cardiac rhythm disturbances and STsegment depression episodes in patients with obstructive sleep apneahypopnea syndrome and its mechanisms.Chest.2005.127 (1); 15-22 .
4.	黃文,呂芳芳,史繼紅,等.阻塞性睡眠呼吸暫停綜合征患者與心律失常的臨床分析[J].山東大學基礎醫學院報,2004,18(3):140-142.
5.	GUILLEMINAULT C, CONNOLL S T, WINKLE RA. Cardiac arrhythmia and conduction disurbances during sleep in 400 patients with sleep apnea Syndrome[J]. A m J Cardiol,1983, 52: 490.
6.	BECKER J T, JR KLEIGER K E, FLEISS J L, et al. Components of heart rate variability measured during healing of acute myocardial infarction[J].Am J Cardiol,1988,61:208-215.
7.	魯慧敏,楊玲,林建海. 阻塞性睡眠呼吸暫停綜合征患者夜間低氧心律失常分析[J]. 同濟大學學報(醫學版),2006, 26(3):52-53.
8.	王璋,司良毅.睡眠呼吸暫停綜合癥致動脈內皮損傷的電鏡研究[J].重慶醫學,2005,34 (4):556.

1. 中華醫學會呼吸病學分會睡眠呼吸疾病學組.阻塞性睡眠呼吸暫停低通氣綜合征診治指南(草案)[J].中華結核和呼吸雜志,2002, 25:195-198.
2. HOFFSTEIN V, MATEI KA S. Cardiac arrhythmias, Snoring and sleep apnea[J]. Chest,1994, 106: 446.
3. ALONSOFERNANDEZ A, GARCIARIO F, RRCIONERO M A, et al. Cardiac rhythm disturbances and STsegment depression episodes in patients with obstructive sleep apneahypopnea syndrome and its mechanisms.Chest.2005.127 (1); 15-22 .
4. 黃文,呂芳芳,史繼紅,等.阻塞性睡眠呼吸暫停綜合征患者與心律失常的臨床分析[J].山東大學基礎醫學院報,2004,18(3):140-142.
5. GUILLEMINAULT C, CONNOLL S T, WINKLE RA. Cardiac arrhythmia and conduction disurbances during sleep in 400 patients with sleep apnea Syndrome[J]. A m J Cardiol,1983, 52: 490.
6. BECKER J T, JR KLEIGER K E, FLEISS J L, et al. Components of heart rate variability measured during healing of acute myocardial infarction[J].Am J Cardiol,1988,61:208-215.
7. 魯慧敏,楊玲,林建海. 阻塞性睡眠呼吸暫停綜合征患者夜間低氧心律失常分析[J]. 同濟大學學報(醫學版),2006, 26(3):52-53.
8. 王璋,司良毅.睡眠呼吸暫停綜合癥致動脈內皮損傷的電鏡研究[J].重慶醫學,2005,34 (4):556.

West China Medical Journal

Nocturnal Arrhythmia in Obstructive Sleep ApneaHypopnea Syndrome

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