目的:評價無創正壓通氣(NIPPV)在救治慢性阻塞性肺疾病(COPD)急性加重期并嚴重呼吸衰竭患者中的臨床療效。方法:對2006年1月至2008年1月入選的47例COPD急性加重期并嚴重呼吸衰竭患者使用雙水平無創正壓呼吸機面罩輔助通氣, 患者均伴有不同程度的意識障礙,動態觀察NIPPV治療前和治療后2 h、8 h、1 d及3 d動脈血氣、神志、治療后患者的轉歸,NIPPV的不良反應及并發癥。結果:本組47例患者中,41例經NIPPV治療2 h、8 h、1 d及3 d后與治療前比較,PaO2明顯升高P lt;0.01,PaCO2明顯降低P lt;0.01,pH明顯升高P lt;0.01,均脫機出院,有效率達87.23%(41/47);6例改為有創通氣,其中3例經有創機械通氣治療后脫機成功,1例因上消化道出血死亡,2例自動出院.結論:雙水平無創正壓通氣對有選擇的COPD急性加重期并嚴重呼吸衰竭患者治療療效確切,它能迅速緩解病情,減少患者的氣管插管和氣管切開以及相應的并發癥,提高生活質量。
Citation：
HE Zhengguang,QIU Rong,XIAO Changwu.. Clinical Investigation of Non-Invasive Positive Pressure Ventilation in Treatment for Patients with Chronic Obstructive Pulmonary Disease and Severe Respiratory Failure. West China Medical Journal, 2009, 24(7): 1724-1726. doi:
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