Serum Level of Macrophage Colony Stimulating Factor in Patients with Colorectal Cancer and its Clinical Significance_West China Medical Journal

Authors：

YANG Zhiming , LIU Bin.

Department of General Surgery, 4thAffiliated Hospital of Guangxi Medical University & Liuzhou Worker’s Hospital, Liuzhou Guangxi 545005, China;

Corresponding?author：

Keywords：

結直腸癌; 巨噬細胞集落刺激因子; 血清; 酶聯免疫吸附分析法

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檢測結直腸癌患者血清巨噬細胞集落刺激因子(M-CSF)的含量并探討其臨床意義。方法:采用酶聯免疫吸附分析法(ELISA)對62例經病理證實的術前結直腸癌患者、40例結直腸良性病患者和40例健康體檢者血清M-CSF水平進行檢測。結果:結直腸癌患者血清M-CSF水平明顯高于結直腸良性病患者和健康體檢者(P lt;0.01);結直腸癌患者血清M-CSF水平與腫瘤分期、淋巴結轉移及遠處轉移有關(P lt;0.05),與性別、年齡、分化程度不相關(P gt;0.05)。結論:M-CS與結直腸癌的腫瘤分期、淋巴結轉移及遠處轉移有關,可能是一個判斷結直腸癌預后的生物學指標。

Citation： YANG Zhiming,LIU Bin.. Serum Level of Macrophage Colony Stimulating Factor in Patients with Colorectal Cancer and its Clinical Significance. West China Medical Journal, 2009, 24(7): 1647-1649. doi: Copy

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1. LAWICKI S, CZYGIER M, BEDKOWSKA E,et al.Comparative evaluation of plasma levels and diagnostic values of macrophagecolony stimulating factor in patients with breast cancer and benign tumors[J].Cancer Pol Arch Med Wewn,2008,118(9):464-469.
2. GROBLEWSKA M, MROCZKO B, WERESZCZYSKASIEMIATKOWSKA U,et al.Serum levels of granulocyte colonystimulating factor (G-CSF) and macrophage colonystimulating factor (M-CSF) in pancreatic cancer patients[J].Clin Chem Lab Med,2007,45(1):30-34.
3. KUROPKAT C, DUENNE A A, HERZ U,et al. Significant correlation of matrix metalloproteinase and macrophage colonystimulating factor serum concentrations in patients with head and neck cancer[J].Neoplasma,2004, 51(5):375-378.
4. IDE H, HATAKE K, TERADO Y,et al. Serum level of macrophage colonystimulating factor is increased in prostate cancer patients with bone metastasis[J].Hum Cell,2008,21(1):1-6.
5. TOY E P, AZODI M, FOLK N L,et al. Enhanced ovarian cancer tumorigenesis and metastasis by the macrophage colonystimulating factor[J].Neoplasia,2009,11(2):136-144.
6. MROCZKO B, GROBLEWSKA M, WERESZCZYSKASIEMIATKOWSKA U, et al. Serum macrophagecolony stimulating factor levels in colorectal cancer patients correlate with lymph node metastasis and poor prognosis[J]. Clin Chim Acta,2007,380(1-2):208-212.
7. CALATAYUD S, WARNER T D, BREESE E J, et al. Relationship between endogenous colony stimulating factors and apoptosis in human colon cancer cells:role of cyclooxygenase inhibitors[J].Br J Pharmacol, 2001,134(6):1237-1244.
8. CALATAYUD S, WARNER T D, BREESE E J, et al. Modulation by colony stimulating factors of human epithelial colon cancer cell apoptosis[J].Cytokine,2002,20(4):163-167.

West China Medical Journal

Serum Level of Macrophage Colony Stimulating Factor in Patients with Colorectal Cancer and its Clinical Significance

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