Association between Interleukin-23 Receptor Gene Polymorphisms and Dilated Cardiomyopathy_West China Medical Journal

Authors：

1.Department of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, China; 2. Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, China;

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Keywords：

自身免疫; 基因多態性; 擴張型心肌病

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目的:本文通過研究白介素23受體(IL-23R)基因多態性與擴張型心肌病(DCM)的相關性,探討DCM患者的免疫遺傳學發病機制. 方法:采用PCR-RFLP方法測定DCM患者和正常對照者IL-23R基因rs7517847位點的單核苷酸多態性. 用卡方檢驗比較病例組與對照組之間基因型頻率和等位基因頻率的統計學差異。結果:IL-23R基因rs7517847位點單核苷酸多態基因型和等位基因頻率在DCM組與正常對照組之間無差異。結論:本研究未發現IL-23R基因rs7517847位點多態性與DCM相關。

Citation： CHEN Yu,PENG Ying,ZHOU Bin,et al. Association between Interleukin-23 Receptor Gene Polymorphisms and Dilated Cardiomyopathy. West China Medical Journal, 2009, 24(4): 870-872. doi: Copy

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1. MARON B J, TOWBIN J A, THIENE G, et al. Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention[J]. Circulation,2006,113:1807-16..
2. FU M. Autoimmunity in idiopathic dilated cardiomyopathy: from patients to molecules and back to patients[J]. Int J Cardiol, 2006, 112:1..
3. PARHAM C, CHIRICA M, TIMANS J, et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R[J]. J Immunol, 2002, 168(11):5699-5708..
4. OPPMANN B, LESLEY R, BLOM B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12[J]. Immunity,2000,13:715-725..
5. PARK H, LI ZX, YANG XO, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing Interleukin 17[J]. Nat lmmunol, 2005, 6(11):1133-1141..
6. LANGRISH CL, CHEN Y, BLUMENSCHEIN WM, et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation[J].J Exp Med, 2005, 201: 233-240..
7. SONDEREGGER I, ROHN, TA, KURRER MO, et al.Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis[J]. Eur J Immunol, 2006, 36(11): 2849-2856..
8. RANGACHARI M,MAUERMANN N,MARTY RR,et al.T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17[J].J Exp Med, 2006, 203(8): 2009 -2019..

West China Medical Journal

Association between Interleukin-23 Receptor Gene Polymorphisms and Dilated Cardiomyopathy

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