The Application Value of Rescue ICSI after Complete Fertilization Failure in Conventional IVF_West China Medical Journal

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Department of Obstetrics and Gynecology, West China Second Hospital of Sichuan University, Chendu 610041, China;

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Keywords：

體外授精; 胚胎移植; 卵胞漿內單精子注射; 補救ICSI

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目的:探討IVF-ET周期中,對常規IVF完全受精失敗的卵子補行卵胞漿內單精子注射精子(Rescue ICSI)的臨床應用價值。方法:在常規IVF后18～22 h,對體外受精完全失敗的12個周期、85個未受精MⅡ期卵行補行ICSI。以同時期進行ICSI的34個周期、226個MⅡ期卵為對照,比較ICSI結局。結果:補救ICSI組與對照組比較,基礎內分泌指標,HCG 日平均血清雌二醇和孕激素水平、子宮內膜厚度,獲MⅡ期卵個數以及平均移植胚胎個數,無顯著性差異。補救ICSI組受精率和卵裂率分別為78.82％、91.04％,與對照組(受精率為80.09%,卵裂率為95.58%)比較,差異無統計學意義。取卵后第3天,補救ICSI組卵裂球數≥5的優質胚胎比例占13.11％,低于對照ICSI組(73.99％),差異有顯著性 (P lt;0.05)。對照ICSI組妊娠率為38.24％,補救ICSI組無一例妊娠。結論:補行ICSI雖然可使常規IVF中未受精卵受精并獲得胚胎,但是所得胚胎的發育潛能差,妊娠率極低,臨床應用價值有限。

Citation： HUANG Zhongying,LI Shangwei,MA Qianhong,et al. The Application Value of Rescue ICSI after Complete Fertilization Failure in Conventional IVF. West China Medical Journal, 2009, 24(4): 851-853. doi: Copy

1.	黃仲英,李尚為,馬黔紅,等. 精子活動力對卵胞漿內單精子注射結局的影響[J]. 生殖與避孕,2006,26(1): 47-48..
2.	莊廣倫主編.現代輔助生育[M]. 第1版, 北京:人民衛生出版社,2005: 238-241..
3.	CHEN C, KARTRERA S. Rescue ICSI of oocytes that failed to extrude the second polar body 6h post-insemination in conventional IVF[J]. Hum Reprod,2003,18(10):2122-2123..
4.	AMARIN Z O, OBEIDATBRTB R, ROUZIA A, et al. Intracyloplasmic sperm injection after total conventional in-vitro fertilization failure[J]. Saudi Med J,2005,26(3):411-415..
5.	DEUGARTE C M, LI M, JORDAN B, et al. Rescue intracytoplasmic sperm injection and preimplantation genetic diagnosis in combination can result in pregnancy [J]. Fertil Steril,2006,86(1):200-202..
6.	曾勇,胡曉東,宋成,等.體外受精失敗后補行卵胞漿內單精子注射的臨床價值探討[J].生殖與避孕,2006,26(1):32-34..
7.	李曉虹,于叢一,麥美琪,等.常規IVF不受精周期行補救卵母細胞單精子注射[J].中山大學學報(醫學科學版),2007,28(2):188-191..
8.	FRIEDLER S, RAZIEL A, STRASSBURGER D, et al. Factors influencing the outcome of ICSI in patients with obstructive and non-obstructive azoospermia: a comparative study[J]. Hum Reprod,2002,17(12):3114-3121..
9.	PEHLIVAN T, RUBIO C, RUIZ A, et al. Embryonic chromosomal abnormalities obtained after rescue intracytoplasmic sperm injection of 1-day-old unfertilized oocytes [J]. J Assist Reprod Genet,2004,21(2):55-57.〖ZK)〗.
10.	NAGY Z P, RIENZI L F, UBALDI F M, et al. Effect of reduced oocyte aging on the outcome of rescue intracytoplasmic sperm injection [J]. Fertil Steril,2006,85(4):901-906..

1. 黃仲英,李尚為,馬黔紅,等. 精子活動力對卵胞漿內單精子注射結局的影響[J]. 生殖與避孕,2006,26(1): 47-48..
2. 莊廣倫主編.現代輔助生育[M]. 第1版, 北京:人民衛生出版社,2005: 238-241..
3. CHEN C, KARTRERA S. Rescue ICSI of oocytes that failed to extrude the second polar body 6h post-insemination in conventional IVF[J]. Hum Reprod,2003,18(10):2122-2123..
4. AMARIN Z O, OBEIDATBRTB R, ROUZIA A, et al. Intracyloplasmic sperm injection after total conventional in-vitro fertilization failure[J]. Saudi Med J,2005,26(3):411-415..
5. DEUGARTE C M, LI M, JORDAN B, et al. Rescue intracytoplasmic sperm injection and preimplantation genetic diagnosis in combination can result in pregnancy [J]. Fertil Steril,2006,86(1):200-202..
6. 曾勇,胡曉東,宋成,等.體外受精失敗后補行卵胞漿內單精子注射的臨床價值探討[J].生殖與避孕,2006,26(1):32-34..
7. 李曉虹,于叢一,麥美琪,等.常規IVF不受精周期行補救卵母細胞單精子注射[J].中山大學學報(醫學科學版),2007,28(2):188-191..
8. FRIEDLER S, RAZIEL A, STRASSBURGER D, et al. Factors influencing the outcome of ICSI in patients with obstructive and non-obstructive azoospermia: a comparative study[J]. Hum Reprod,2002,17(12):3114-3121..
9. PEHLIVAN T, RUBIO C, RUIZ A, et al. Embryonic chromosomal abnormalities obtained after rescue intracytoplasmic sperm injection of 1-day-old unfertilized oocytes [J]. J Assist Reprod Genet,2004,21(2):55-57.〖ZK)〗.
10. NAGY Z P, RIENZI L F, UBALDI F M, et al. Effect of reduced oocyte aging on the outcome of rescue intracytoplasmic sperm injection [J]. Fertil Steril,2006,85(4):901-906..

West China Medical Journal

The Application Value of Rescue ICSI after Complete Fertilization Failure in Conventional IVF

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