Case-control Study between Estrogen Receptor Gene Polymorphisms and Osteoarthritis in Southern Sichuan High Fluoride Areas_West China Medical Journal

Authors：

YANG Jiexiang , FU Shijie , XIAO Fushen

Affiliated Second Hospital of Luzhou Medical University, Luzhou Sichuan 646000, China;

Corresponding?author：

Keywords：

骨關節炎; 雌激素受體基因; 多態性; 氟

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目的:探討川南高氟地區人群雌激素受體基因PvuⅡ和XbaⅠ核酸限制性內切酶多態性與膝骨性關節炎的相關性。方法:對川南高氟地區41例膝骨性關節炎患者及40例對照組,用聚合酶鏈反應限制性片段長度多態性(PCR-RFLP)的方法鑒定雌激素受體的基因型,分析雌激素受體基因多態性與膝骨性關節炎的關系及各基因型在病例組與對照組的分布。結果:41例病例組與40例對照組X基因型及P基因型頻率分布差異無顯著性(P gt;0.05)。結論:川南高氟地區人群ER基因多態性與OA無明確相關性。

Citation： YANG Jiexiang,FU Shijie,XIAO Fushen. Case-control Study between Estrogen Receptor Gene Polymorphisms and Osteoarthritis in Southern Sichuan High Fluoride Areas. West China Medical Journal, 2009, 24(4): 826-829. doi: Copy

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1.  趙喜森.重癥難治性休克的機制和治療[J].中華創傷雜志,2003,19(16):325..
2. VARELA J E, COHN S M, DIAZ I, et al. Splanchnic perfusion during delayed, hypotensive, or aggressive fluid resuscitation from uncontrolled hemorrhage[J]. Shock,2003,20(5):476-480..
3. 王一鏜.嚴重創傷救治的策略-損傷控制性手術[J].中華創傷雜志,2005,21(1):32-35..
4. HOEY B A, SCHWAB C W. Damage control surgery[J]. Scand J Surg,2002,91(1):92-103..
5. WETZEL R C. Multiple trauma in children; critical care overview[J]. Crit Care Med,2002,30:s468-477..
6. WANEK S, MAYBERRY J C. Blunt thoracic trauma: flail chest, pulmonary contusion, and blast injury[J]. Crit Care Clin,2004,20(1):71-81..
7. BUDUHAN G,MCR ITCHIE D I. Missed injuries in patients with multiple trauma [J]. J Trauma,2000,49(3):600-605..
8. 張連陽.努力提高多發傷救治速度[J].中華創傷雜志,2007,23(4):241-243.

West China Medical Journal

Case-control Study between Estrogen Receptor Gene Polymorphisms and Osteoarthritis in Southern Sichuan High Fluoride Areas

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